Abstract:ObjectivesResearchers need to be confident about the reliability of epidemiologic studies that quantify medication use through self-report. Some evidence suggests that psychiatric medications are systemically under-reported. Modern record linkage enables validation of self-report with national prescribing data as gold standard. Here, we investigated the validity of medication self-report for multiple medication types.Study Design and SettingParticipants in the Generation Scotland population-based cohort (N = 1… Show more
“…Furthermore, some prior studies relied on self‐reported use, while others had access to computerized pharmacy data. The latter is likely to have greater validity . Another possible explanation could be differences in the ability to control for potential confounding factors, including concomitant medication use, physical activity, smoking, BMI, ADLs or IADLs, gait speed, and exercise (all of which the present study was able to consider).…”
“…Furthermore, some prior studies relied on self‐reported use, while others had access to computerized pharmacy data. The latter is likely to have greater validity . Another possible explanation could be differences in the ability to control for potential confounding factors, including concomitant medication use, physical activity, smoking, BMI, ADLs or IADLs, gait speed, and exercise (all of which the present study was able to consider).…”
“…Self-reported use of prescription tranquilizers is expected to be reliable and valid (Haapea et al, 2010;Hafferty et al, 2018;Rauma et al, 2013). Use of prescription tranquilizer medication was asked in the Tromsø VI (2007-08) questionnaire as: "How often have you used prescription tranquilizers during the last four weeks?"…”
Section: Use Of Prescription Tranquilizers (Tromsø Vi)mentioning
These findings suggest that physical inactivity increases the risk of psychiatric morbidity (albeit, measured via use of prescription tranquilizers). Future regionally representative and longitudinal research is required to confirm/refute our findings and explore underlying mechanisms.
“…A total of 267 publications were identified over the period January 2009 to March 2019. After screening titles and abstracts, and removing duplicates and conference abstracts, 40 full publication articles were included and reviewed . The number of articles published by year for the period 2014–2018, totalling 37, is presented in Figure A; a further 3 studies were published in the first months of 2019.…”
Medicines are a major component of modern healthcare delivery, both in resource consumption and as drivers of innovation. The ever‐increasing application of digitalisation within day‐to‐day living and as part of our healthcare systems—with the resultant data generation—presents the opportunity to better define the populations exposed to medicines, and their benefits and harm in real world settings. This article outlines the development of the Scottish National Prescribing Information System (PIS) and describes how this capability is being used to support the safe and effective use of medicines, both nationally and internationally. Since 2009, PIS has included e‐prescribed/e‐dispensed and reimbursed medicines data, now totalling 976 million prescriptions, with codified structured data on dose instructions. A literature review, covering the period from January 2009 to March 2019, identified 40 full publications using PIS, the first occurring in 2014. The majority involved pharmacoepidemiology/drug‐use studies (50%) in cancer and cardiovascular disease. Measuring the value and impact of PIS was extended beyond publication quantification by illustrating the translation of PIS outputs into the learning health system at scale. The developing Scottish capabilities add breadth and depth to the wider evolving international environment, and offer the potential to contribute collegiately to the global effort on medicine safety and effectiveness, including support for the World Health Organisation Global Patient Safety Challenge: Medication Without Harm.
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