Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa

Ramlagan, Shandir; Peltzer, Karl; Ruiter, Robert A. C.; Rodriguez, Violeta J.; Sifunda, Sibusiso

doi:10.1007/s10461-019-02563-z

Cited by 9 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Psychological distress and HIV are often co‐morbid with HIV‐positive pregnant women globally (Chesney & Folkman, 1994 ; Peltzer, Ogawa, Tusher, Farnan, & Gerkovich, 2016 ). Psychological distress has also been reported to limit antiretroviral therapy (ART) adherence in this population (Ramlagan et al, 2019 ), and this is problematic when compared with the normal population of pregnant women or pregnant women with other chronic conditions (Staneva, Morawska, Bogossian, & Wittkowski, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Experiences and predictors of psychological distress in pregnant women living with HIV

Ogueji

2021

British J Health Psychol

View full text Add to dashboard Cite

Objectives. To explore the experiences and predictors of psychological distress in pregnant women living with HIV. Design. A mixed-methods research design. Methods. A representative randomly sampled 840 (age range 22-46 years) HIVpositive pregnant women in Akwa Ibom, Benue, and Rivers States of Nigeria enrolled for the study. Data were collected using standardized questionnaires and in-depth interviews for 4 months and 3 weeks in 6 HIV treatment centres. Collected data were analysed using IBM SPSS statistics (v. 22.0) and thematic analysis. Results. The mean score on psychological distress was 17.07 AE 5.86. Multiple regression analysis found a significant joint prediction of meaning in life, self-compassion, and acceptance of illness on psychological distress, R = .64, R 2 = .41; F (3,828) = 186.18; p = .000, with 41% variance explained. Further, there was a significant independent prediction of each predictor at meaning in life (b = À.19, t = À5.08; p = .000), self-compassion (b = À.23, t = À5.59; p = .000), and acceptance of illness (b = À.30, t = À7.23; p = .000), with acceptance of illness exerting the greatest independent predictive impact. Socio-demographic variables (age, length of living with HIV, high-risk state, highest education attained, marital status, and religious affiliation) had no significant contribution to psychological distress. Qualitative analysis found 'anxious concerns', 'depressive reports, loneliness, and regrets', 'self-blame and guilt feelings', as the experiences of psychological distress, and these experiences were determined by respondents' socio-cultural contexts. Conclusion. These findings emphasize the importance of psychosocial care for HIVpositive pregnant women. Statement of Contribution What is already known about this subject? Pregnant women living with HIV are often psychologically distressed from being pregnant and living with HIV at the same time. Understanding the experiences and predictors of psychological distress can contribute to inform targeted interventions for this population. However, the possible experiences of and factors predicting psychological distress in this population remain scant. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Introductionmentioning

confidence: 99%

Experiences and predictors of psychological distress in pregnant women living with HIV

Ogueji

2021

British J Health Psychol

View full text Add to dashboard Cite

show abstract

“…In South Africa, alcohol use during pregnancy is a major public health problem. High levels of problematic alcohol use have been observed among women living both with and without HIV in this setting [ 63 – 67 ], and substance use itself is a risk factor for poor ART outcomes [ 19 , 24 , 67 – 70 ]. Notably, alcohol use modified the intervention effect in this trial, with the intervention not associated with retention in HIV care and viral suppression among women reporting risky drinking in the 12 months prior to pregnancy recognition.…”

Section: Discussionmentioning

confidence: 99%

Why do Integrated Maternal HIV and Infant Healthcare Services work? A Secondary Analysis of a Randomised Controlled Trial in South Africa

et al. 2023

View full text Add to dashboard Cite

In a randomised trial, we found that integrated maternal HIV and infant health services through the end of breastfeeding were significantly associated with the primary outcome of engagement in HIV care and viral suppression at 12 months postpartum, compared to the standard of care. Here, we quantitatively explore potential psychosocial modifiers and mediators of this association. Our findings suggest that the intervention was significantly more effective among women experiencing an unintended pregnancy but did not improve outcomes among women reporting risky alcohol use. Although not statistically significant, our results suggest that the intervention may also be more effective among women experiencing higher levels of poverty and HIV-related stigma. We observed no definitive mediator of the intervention effect, but women allocated to integrated services reported better relationships with their healthcare providers through 12 months postpartum. These findings point to high-risk groups that may benefit the most from integrated care, as well as groups for whom these benefits are hampered and that warrant further attention in intervention development and evaluation.

show abstract

“…Collinearity between years on ART and adherence club membership duration was investigated by examining correlation coefficients and variance inflation factors. Based on a priori knowledge, age [11][12][13] and then sex [13][14][15][16][17] were assessed to determine whether they improved the model fit using the Wald and Likelihood Ratio (LR) tests. Age was retained, but sex did not improve the final model.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have investigated factors influencing ART adherence among adherence club members. In studies assessing factors affecting adherence in SOC or factors affecting viral load suppression and retention in care in adherence clubs, several determinants of ART adherence have been identified, including age [11][12][13], sex [13][14][15][16][17], marital status [13][14][15][16][17], highest educational attainment [12,16,18,19] and employment [14,20,21]. The presence of comorbidities [16], the specific ART regimen [16,[22][23][24][25] and the duration of ART treatment [12,26,27] are some of the clinical factors that have been associated with ART adherence.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study

Ndoro

Ndlovu²,

Nyasulu³

2022

PLoS ONE

View full text Add to dashboard Cite

Background HIV is a leading cause of morbidity and mortality in South Africa that can be managed using antiretroviral therapy (ART). Adherence clubs are interventions that have been introduced to decentralize ART to improve ART adherence and provide social support for club members. However, ART adherence can be suboptimal even among adherence club members. Aim This study aimed to determine the factors affecting ART adherence among people living with HIV/AIDS (PLWHA) attending adherence clubs in Ekurhuleni Metropolitan Municipality. Methods A cross-sectional study was conducted. Ordinal logistic regression was used in univariable and multivariable analyses to determine factors significantly associated with adherence scores. Factors included in the final model were age, comorbidity, ART regimen and club membership duration. Results The records of 730 participants were analysed. After adjusting for age, participants with comorbidities were half as likely to report high ART adherence scores compared to participants without comorbidities (AOR = 0.5, 95% CI: 0.3–0.8, p = 0.005). The adjusted odds of reporting high levels of adherence among participants on cART were 1.8 times those on a single tablet regimen (AOR = 1.8, 95% CI: 1.0–3.2; p = 0.033). There was a 20% reduction in the adjusted odds of reporting high ART adherence for each additional year of adherence club membership (AOR = 0.8, 95% CI: 0.8–0.9, p<0.001). Conclusion Increasing years spent as adherence club members, single tablet ART regimens and the presence of comorbidities were all significantly associated with low ART adherence among study participants. Regular assessment of the quality of counselling sessions for ART adherence club members and questionnaires for early screening of treatment fatigue have been suggested as tools for improved adherence in ART adherence club settings.

show abstract

Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa

Cited by 9 publications

References 25 publications

Experiences and predictors of psychological distress in pregnant women living with HIV

Experiences and predictors of psychological distress in pregnant women living with HIV

Why do Integrated Maternal HIV and Infant Healthcare Services work? A Secondary Analysis of a Randomised Controlled Trial in South Africa

Factors associated with ART adherence among HIV-positive adherence club members in Ekurhuleni Metropolitan Municipality, South Africa: A cross-sectional study

Contact Info

Product

Resources

About