Self-reported inhibition predicts history of suicide attempts in bipolar disorder and major depression

Ponsoni, André; Branco, Laura Damiani; Cotrena, Charles; Shansis, Flávio; Grassi‐Oliveira, Rodrigo; Fonseca, Róchele Paz

doi:10.1016/j.comppsych.2018.01.011

Cited by 45 publications

(17 citation statements)

References 61 publications

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“…Suicide behaviour is highly prevalent amongst patients with MDD, 11,175 however, depression per se is not a useful tool for a proper understanding of the complexity of suicide, and SI is not a proxy for the diagnosis of MDD. 176 The uniqueness of each patient determines the variability of the threshold for sustaining mental pain, a condition dependent on personal experiences, emotional states and intimate situation experienced from childhood.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] The association between MDD and suicide attempts (SA) and/or ideation (SI) has been well documented, being SI and suicidal behaviour frequently reported during depressive episodes, with a suicide risk rate equivalent to around 15%. 3,[9][10][11] Furthermore, epidemiological studies reported as well that MDD subjects with comorbid anxiety disorders were among the main predictors of SA amongst depressed suicide subjects. 12 However, the role of comorbid anxiety disorders, in increasing suicidal risk is still a matter of debate although it has been well recognized that the association between MDD and anxiety disorders appear to have more a synergic role in increasing suicidal risk.…”

Section: Introductionmentioning

confidence: 99%

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Understanding the Complex of Suicide in Depression: from Research to Clinics

Orsolini

Latini²,

Pompili³

et al. 2020

Psychiatry Investig

234

167

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Objective Amongst psychiatric disorders, major depressive disorder (MDD) is the most prevalent, by affecting approximately 15–17% of the population and showing a high suicide risk rate equivalent to around 15%. The present comprehensive overview aims at evaluating main research studies in the field of MDD at suicide risk, by proposing as well as a schematic suicide risk stratification and useful flow-chart for planning suicide preventive and therapeutic interventions for clinicians.Methods A broad and comprehensive overview has been here conducted by using PubMed/Medline, combining the search strategy of free text terms and exploded MESH headings for the topics of ‘Major Depressive Disorder’ and ‘Suicide’ as following: ((<i>suicide</i> [Title/Abstract]) AND (<i>major depressive disorder</i> [Title/Abstract])). All articles published in English through May 31, 2019 were summarized in a comprehensive way.Results Despite possible pathophysiological factors which may explain the complexity of suicide in MDD, scientific evidence supposed the synergic role of genetics, exogenous and endogenous stressors (i.e., interpersonal, professional, financial, as well as psychiatric disorders), epigenetic, the hypothalamic-pituitary-adrenal stress-response system, the involvement of the monoaminergic neurotransmitter systems, particularly the serotonergic ones, the lipid profile, neuro-immunological biomarkers, the Brain-derived neurotrophic factor and other neuromodulators.Conclusion The present overview reported that suicide is a highly complex and multifaceted phenomenon in which a large plethora of mechanisms could be variable implicated, particularly amongst MDD subjects. Beyond these consideration, modern psychiatry needs a better interpretation of suicide risk with a more careful assessment of suicide risk stratification and planning of clinical and treatment interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Understanding the Complex of Suicide in Depression: from Research to Clinics

Orsolini

Latini²,

Pompili³

et al. 2020

Psychiatry Investig

234

167

View full text Add to dashboard Cite

show abstract

“…Recent studies using the Barratt Impulsiveness Scale (BIS; Patton et al, 1995) have indicated a connection between impulsivity and suicide risk (Izci et al, 2016;Ponsoni, et al, 2018;Menon et al, 2015). In particular, higher BIS-11 attention factor scores were found to be higher in adults with bipolar II disorder with a history of suicide attempts and higher BIS-11 motor and nonplanning factor scores in adults with bipolar I with histories of suicide attempt when compared to a nonclinical matched control group (Izci et al, 2016).…”

Section: Impulsivity and Suicide Riskmentioning

confidence: 99%

College Student Suicide Risk: The Relationship between Alexithymia, Impulsivity, and Internal Locus of Control

Loftis

Michael

Luke

2019

IJEP

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Suicide has become the second leading cause of death for individuals between 15 and 29 years old and increasingly more common within college students (WHO, 2016). The purpose of this study was to examine the associations among alexithymia, impulsivity, and locus of control as predictors of suicide risk in college students. Participants were comprised of 550 undergraduate students from two universities in the southeastern United States. Multiple regression analyses were examined to evaluate what variables could be significant predictors of suicide risk in college students. Age, alexithymia subscales of difficulty identifying feelings and externally oriented thinking, and impulsivity subscales of motor, self-control, and nonplanning were considered significant in the regression analysis of suicide risk. Psychoeducational implications, limitations, and future directions are also discussed.

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“…In terms of suicidal behaviour, impulsivity could play an important role in the transition of suicidal ideations into attempt [ 32 ] and could interact with depressive state and hopelessness [ 33 ]. Impulsivity was indeed proved to be a possible characteristic of depressive state and an important indicator of suicide risk among different groups of individuals: distinct aspects of impulsivity could differentiate persons with mental disorders from healthy controls [ 34 ], depressive states from manic states [ 33 ], and differ among patients with or without a history of a suicide attempt [ 9 , 34 ]. Besides, certain facets could be sensitive for suicide ideation or intent [ 32 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Temperament, character and decision-making characteristics of patients with major depressive disorder following a suicide attempt

et al. 2021

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Background Multiple psychological factors of suicidal behaviour have been identified so far; however, little is known about state-dependent alterations and the interplay of the most prominent components in a suicidal crisis. Thus, the combined effect of particular personality characteristics and decision-making performance was observed within individuals who recently attempted suicide during a major depressive episode. Methods Fifty-nine medication-free major depressed patients with a recent suicide attempt (within 72 h) and forty-five healthy control individuals were enrolled in this cross-sectional study. Temperament and character factors, impulsivity and decision-making performance were assessed. Statistical analyses aimed to explore between-group differences and the most powerful contributors to suicidal behaviour during a depressive episode. Results Decision-making and personality differences (i.e. impulsivity, harm avoidance, self-directedness, cooperativeness and transcendence) were observed between the patient and the control group. Among these variables, decision-making, harm avoidance and self-directedness were shown to have the strongest impact on a recent suicide attempt of individuals with a diagnosis of major depressive disorder according to the results of the binary logistic regression analysis. The model was significant, adequately fitted the data and correctly classified 79.8% of the cases. Conclusions The relevance of deficient decision-making, high harm avoidance and low self-directedness was modelled in the case of major depressed participants with a recent suicide attempt; meaning that these individuals can be described with the myopia for future consequences, a pessimistic, anxious temperament; and a character component resulting in the experience of aimlessness and helplessness. Further studies that use a within-subject design should identify and confirm additional characteristics specific to the suicidal mind.

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Self-reported inhibition predicts history of suicide attempts in bipolar disorder and major depression

Cited by 45 publications

References 61 publications

Understanding the Complex of Suicide in Depression: from Research to Clinics

Understanding the Complex of Suicide in Depression: from Research to Clinics

College Student Suicide Risk: The Relationship between Alexithymia, Impulsivity, and Internal Locus of Control

Temperament, character and decision-making characteristics of patients with major depressive disorder following a suicide attempt

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