Research indicates that people with serious mental illnesses (SMI; e.g., schizophrenia, schizoaffective disorder, bipolar disorder) are at enhanced risk for infection with the human immunodeficiency virus (HIV). To decrease this risk, we piloted a six-session HIV-risk reduction intervention for two single-gender groups (9 women, 8 men; M age = 39.8 years) of SMI outpatients. The intervention and assessment were based on the Information-Motivation-Behavioral Skills model of HIV-preventive behavior (Fisher & Fisher, 1992) and employed activities designed specifically for people with a SMI. Data were collected at pre-and post-intervention, and at a one-month followup. Results indicated that this brief intervention resulted in enhanced HIV-related knowledge, and trends toward enhanced skill at condom use negotiation and condom use self-efficacy. Overall, a modest decrease in risk behavior among participants was observed. Thus, this pilot investigation revealed that HIV-related risk of the SMI can be reduced through traditional behavioral skills and education methods. Future research employing control groups, more intensive interventions, and baseline screening for high risk is encouraged.The term seriously mentally ill (SMI) typically refers to a heterogeneous group of approximately 2.8 million individuals (Auerbach, Wypijewska, & Brodie, 1994) who are diagnosed with psychotic or affective disorders (e.g., schizophrenia, schizoaffective disorder, bipolar disorder), and who exhibit chronic psychiatric symptoms, requiring at least short-term hospitalizations. Contrary to the stereotypical image of the asexual psychiatric patient (Harvis & Trivelli, 1990), recent surveys indicate that many SMI are sexually active, engage in high risk sexual behaviors, and experience enhanced risk for sexually transmitted diseases, including the human immunodeficiency virus (HIV; cf. Kalichman, Carey, & Carey, in press). Despite these characteristics and risk, researchers have been slow to address sexual risks among the SMI.Several recent survey studies have examined sexual risk behavior among the SMI (e.g., Cournos et al., 1994; Carey, Carey, Weinhardt, & Gordon, in press; Kalichman, Kelly, Johnson, & Bulto 1995;Kelly et al., 1992;Knox, Boaz, Friedrich, & Dow, 1994). These studies, which have been conducted across an array of treatment settings (i.e., inpatient, outpatient, homeless shelters) and geographic locations (e.g., Milwaukee, New York City, Syracuse), document that the SMI engage in behaviors that facilitate the transmission of HIV. Risk behaviors include unprotected intercourse, multiple sexual partners, high-risk partners (e.g., injection drug users), anonymous sexual partners, and use of alcohol and other drugs before sex.In addition to these risk behavior studies, a number of HIV-seroprevalence studies have been conducted with SMI samples. Carey, Weinhardt, and Carey (1995) aggregated the results across published seroprevalence studies and found that 5% (i.e., 28 / 550) of SMI women and 10% (i.e., 82 / 832) of SMI...