Self-Reported Health Effects among Community Residents Exposed to Perfluorooctanoate

Anderson-Mahoney, Pamela; Kotlerman, Jenny; Takhar, Harpreet; Gray, David B.; Dahlgren, James

doi:10.2190/ns.18.2.d

Cited by 46 publications

(57 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data suggest that PFOA has the potential to augment IgEmediated responses induced by other environmental and occupational allergens. Consistent with this hypothesis, a significantly greater prevalence of self-reported cases of chronic bronchitis and asthma was documented in individuals residing in a community with prolonged exposure to PFOA in their drinking water as compared to the general population (Anderson-Mahoney et al 2008).…”

mentioning

confidence: 54%

Dermal Penetration Potential of Perfluorooctanoic Acid (PFOA) in Human and Mouse Skin

Franko

Meade

Frasch

et al. 2011

Journal of Toxicology and Environmental Health, Part A

View full text Add to dashboard Cite

Recent data, using a murine model, have indicated that dermal exposure to perfluorooctanoic acid (PFOA) induces immune modulation, suggesting that this may be an important route of PFOA exposure. To investigate the dermal penetration potential of PFOA, serum concentrations were analyzed in mice following topical application. Statistically significant and dose-responsive increases in serum PFOA concentrations were identified. In vitro dermal penetration studies also demonstrated that PFOA permeates both mouse and human skin. Investigation into the mechanisms mediating PFOA penetration demonstrated that dermal absorption was strongly dependent upon the ionization status of PFOA. In addition, PFOA solid, but not 1% PFOA/acetone solution, was identified as corrosive using a cultured epidermis in vitro model. Despite its corrosive potential, expression of inflammatory cytokines in the skin of topically exposed mice was not altered. These data suggest that PFOA is dermally absorbed and that under certain conditions the skin may be a significant route of exposure.

show abstract

mentioning

confidence: 54%

Dermal Penetration Potential of Perfluorooctanoic Acid (PFOA) in Human and Mouse Skin

Franko

Meade

Frasch

et al. 2011

Journal of Toxicology and Environmental Health, Part A

View full text Add to dashboard Cite

show abstract

“…Although the role that basophils play in the immune system has not been thoroughly investigated in the past, recent studies revealed their crucial role in various immune responses such as allergy and anti-parasitic protective immunity [53]. Importantly, elevated IgE concentrations correlate with increased numbers of circulating basophils both in mice and in humans [54], and recent evidence from epidemiologic and animal studies suggests that PFASs may be associated with allergy and asthma-related outcomes, perhaps as a result of a shift in the host’s immune state toward a more TH2-like state [55-59]. …”

Section: Discussionmentioning

confidence: 99%

Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants

Oulhote

Shamim

Kielsen

et al. 2017

Reproductive Toxicology

View full text Add to dashboard Cite

Background To explore possible markers of developmental immunotoxicity, we prospectively examined 56 children to determine associations between exposures to methylmercury and persistent organic pollutants since birth and the comprehensive differential counts of white blood cells (WBC) at age 5 years. Materials and methods Extended differential count included: neutrophils, eosinophils, basophils, lymphocytes (including T cells, NK cells, and B cells), and monocytes. Organochlorine compounds (OCs) including polychlorinated biphenyls (PCBs) and pesticides, five perfluoroalkyl substances (PFASs), and total mercury (Hg) were measured in maternal (n=56) and children’s blood at 18 months (n=42) and 5 years (n=56). We constructed latent functions for exposures at three different ages using factor analyses and applied structural equation models adjusted for covariates. Results Prenatal mercury exposure was associated with depleted total WBC, especially for lymphocytes, where a one standard deviation (SD) increase in the exposure was associated with a decrease by 23% SD (95% CI: −43, −4) in the cell count. Prenatal exposure to OCs was marginally associated with decreases in neutrophil counts. In contrast, the 5-year PFASs concentrations were associated with higher basophil counts (B= 46% SD, 95% CI: 13, 79). Significantly reduced subpopulations of lymphocytes such as B cells, CD4-positive T helper cells and CD4 positive recent thymic emigrants may suggest cellular immunity effects and dysregulation of T-cell mediated immunity. Conclusion Developmental exposure to environmental immunotoxicants appears to have different impacts on WBC counts in childhood.

show abstract

“…Decreased birth weight [8,10] Early pregnancy loss, increased neonatal mortality, delayed eye opening, growth deficits, altered pubertal maturation [87,91] Behavioral and neurotoxicities Decreases in food consumption and body weight [85] Decreased food intake, reduced habituation and hyperactivity, hypoactive response to nicotine [94,96] Other Higher prevalence of angina, myocardial infarction, stroke, chronic bronchitis, shortness of breath on stairs, asthma [78] PFOS Carcinogenicity Bladder cancer mortality [9] Hepatocellular adenoma, thyroid follicular cell adenoma [80] Hepatotoxicities Possible increase in cholesterol, decrease in high-density cholesterol, initial decrease and subsequent increase in total bilirubin [76] Decreased body weights, increased liver weights, lowered serum total cholesterol levels, lowered estradiol levels, no peroxisome proliferation [86] Peroxisome proliferation, mild increase in hepatic palmitoyl CoA oxidase [80] Developmental toxicities Decreased birth weight, ponderal index, and head circumference [10] Increased relative liver weight of pups, delayed eye opening, neonatal death due to intracranial blood vessel dilatation and lung atelectasis, decreased natural killer cell function in male pups [88][89][90] Behavioral and neurotoxicities…”

Section: Pfoa Carcinogenicitymentioning

confidence: 99%

“…Hepatic, lipid, and thyroid parameters, which are known toxicological effects in rodents, showed inconsistent associations with serum levels of PFOS and PFOA in fluorochemical workers [75][76][77]. Besides hepatotoxicity, higher prevalences of cardiovascular and respiratory diseases were reported in plaintiffs or potential plaintiffs in a lawsuit, which might be biased [78]. Two epidemiological studies in the USA and Denmark showed an inverse correlation between PFC concentrations (cord or maternal blood) and birth weight [8,10].…”

Section: Pfoa Carcinogenicitymentioning

confidence: 99%

Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities

Harada

2008

Environ Health Prev Med

View full text Add to dashboard Cite

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) comprise a class of per- and poly-fluorinated compounds that have been detected in the environment as well as in humans. The aim of this review is to summarize several monitoring studies in Japan and characterize the toxicokinetics of these compounds. We found that the levels of contamination by these compounds had unique patterns in Japan. The levels of PFOA in serum from inhabitants of the Kansai region were higher than those of other regions. The PFOA levels in air and water samples from the Kansai region were also relatively high. The estimated intakes from these routes partly explain the differences in the serum levels. The toxicokinetics of these compounds have been investigated. Serum samples from male participants had significantly higher geometric means for PFOS and PFOA compared to samples from female participants. This sex-related difference was partly simulated by menstrual blood loss. There are large interspecies differences in the excretion pathways of these compounds. The serum clearances of PFOA via urine were 300-1,000-fold lower in humans than in Wistar rats and Japanese macaques. On the other hand, the biliary excretion of these compounds was comparable in rats and humans, and the long half-lives in humans may be attributable to the low levels of urinary excretion and high biliary reabsorption rates. These findings suggest that qualitative differences in the excretion routes exist between humans and other species. For risk assessment of these compounds, further information regarding sources of exposure and their toxicokinetics is needed.

show abstract

Self-Reported Health Effects among Community Residents Exposed to Perfluorooctanoate

Cited by 46 publications

References 29 publications

Dermal Penetration Potential of Perfluorooctanoic Acid (PFOA) in Human and Mouse Skin

Dermal Penetration Potential of Perfluorooctanoic Acid (PFOA) in Human and Mouse Skin

Children’s white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants

Environmental and biological monitoring of persistent fluorinated compounds in Japan and their toxicities

Contact Info

Product

Resources

About