Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy

Young-Wolff, Kelly C.; Sarovar, Varada; Tucker, Lue-Yen; Conway, Amy; Alexeeff, Stacey; Weisner, Constance; Armstrong, Mary Anne; Goler, Nancy

doi:10.1001/jamanetworkopen.2019.6471

Cited by 104 publications

(87 citation statements)

References 30 publications

(71 reference statements)

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“…Cannabis is currently the most widely used illicit drug in the world, and its consumption by pregnant women has been steadily increasing [ 1 – 4 ]. Further, the majority of pregnant women estimate little-or-no risk associated with cannabis use during pregnancy [ 5 ], and a trend towards recommendations for cannabis use during the perinatal period has been noted in areas of the United States where cannabis use has been legalized [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Perinatal THC exposure via lactation induces lasting alterations to social behavior and prefrontal cortex function in rats at adulthood

Scheyer

Borsoi

Alicot

et al. 2020

Neuropsychopharmacol.

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Cannabis is the world’s most widely abused illicit drug and consumption amongst women during and surrounding the period of pregnancy is increasing. Previously, we have shown that cannabinoid exposure via lactation during the early postnatal period disrupts early developmental trajectories of prefrontal cortex maturation and induces behavioral abnormalities during the first weeks of life in male and female rat progeny. Here, we investigated the lasting consequences of this postnatal cannabinoid exposure on synaptic and behavioral parameters in the adult offspring of ∆9-tetrahydrocannabinol (THC)-treated dams. At adulthood, these perinatally THC-exposed rats exhibits deficits in social discrimination accompanied by an overall augmentation of social exploratory behavior. These behavioral alterations were further correlated with multiple abnormalities in synaptic plasticity in the prefrontal cortex, including lost endocannabinoid-mediated long-term depression (LTD), lost long-term potentiation and augmented mGlu2/3-LTD. Finally, basic parameters of intrinsic excitability at prefrontal cortex pyramidal neurons were similarly altered by the perinatal THC exposure. Thus, perinatal THC exposure via lactation induces lasting deficits in behavior and synaptic function which persist into adulthood life in male and female progeny.

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Section: Introductionmentioning

confidence: 99%

Perinatal THC exposure via lactation induces lasting alterations to social behavior and prefrontal cortex function in rats at adulthood

Scheyer

Borsoi

Alicot

et al. 2020

Neuropsychopharmacol.

View full text Add to dashboard Cite

show abstract

“…Cannabis is currently the most widely used illicit drug in the world, and its consumption by pregnant women has been steadily increasing [1][2][3][4] . Further, the majority of pregnant women estimate little-or-no risk associated with cannabis use during pregnancy 5 , and a trend towards recommendations for cannabis use during the perinatal period has been noted in areas of the United States where cannabis use has been legalized 6 .…”

Section: Introductionmentioning

confidence: 99%

Perinatal THC Exposure via Lactation Induces Lasting Alterations to Social Behavior and Prefrontal Cortex Function in Rats at Adulthood

Scheyer

Borsoi

Manzoni

2020

Preprint

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175 words Main text: 3871 words Figures: 4 main, 5 tables AbstractCannabis is the world's most widely abused illicit drug and consumption amongst women during and surrounding the period of pregnancy is increasing. Previously, we have shown that cannabinoid exposure via lactation during the early postnatal period disrupts early developmental trajectories of prefrontal cortex maturation and induces behavioral abnormalities during the first weeks of life in male and female rat progeny. Here, we investigated the lasting consequences of this postnatal cannabinoid exposure on synaptic and behavioral parameters in the adult offspring of ∆9-tetrahydrocannabinol (THC)-treated dams. At adulthood, these perinatally THC-exposed rats exhibits deficits in social discrimination accompanied by an overall augmentation of social exploratory behavior. These behavioral alterations were further correlated with multiple abnormalities in synaptic plasticity in the prefrontal cortex, including lost endocannabinoid-mediated long-term depression (LTD), lost long-term potentiation and augmented mGlu2/3-LTD. Finally, basic parameters of intrinsic excitability at prefrontal cortex pyramidal neurons were similarly altered by the perinatal THC exposure. Thus, perinatal THC exposure via lactation induces lasting deficits in behavior and synaptic function which persist into adulthood life in male and female progeny.

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“…According to a study performed from 2018 to 2019, the consumption during the year before pregnancy increased daily from 1.17 to 3.05%, weekly from 1.39 to 2.73%, and monthly from 4.26 to 6.74%. Additionally, during pregnancy, daily use increased from 0.28 to 0.69%, weekly from 0.49 to 0.92%, and monthly from 1.18 to 1.77% (25).…”

Section: Introductionmentioning

confidence: 97%

Cannabis Use in Pregnant and Breastfeeding Women: Behavioral and Neurobiological Consequences

et al. 2020

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Nowadays, cannabis is the most consumed illicit drug. The global prevalence of the use of cannabis in 2017 was estimated in 188 million of people, 3.8% of worldwide population. Importantly, the legalization of cannabis in different countries, together with the increase in the apparent safety perception, may result in a great variety of health problems. Indeed, an important concern is the increase in cannabis use among pregnant and breastfeeding women, especially since the content of delta9-tetrahidrocannabinol (THC) is currently around 2-fold higher than it was 15-20 years ago. The purpose of this study was to review cannabis use during pregnancy and breastfeeding including epidemiological aspects, therapeutic or preventive strategies, and experimental considerations and results from animal models of perinatal cannabis exposure to analyze the underlying neurobiological mechanisms and to identify new therapeutic approaches. A recent report revealed that among pregnant women aged 15-44, last month cannabis use prevalence was over 4.9%, raising to 8.5% in the 18-25-year-old age range. Pre-and post-natal exposure to cannabis may be associated with critical alterations in the newborn infants that are prolonged throughout childhood and adolescence. Briefly, several reports revealed that perinatal cannabis exposure was associated with low birth weight, reduction in the head circumference, cognitive deficits (attention, learning, and memory), disturbances in emotional response leading to aggressiveness, high impulsivity, or affective disorders, and higher risk to develop a substance use disorder. Furthermore, important neurobiological alterations in different neuromodulatory and neurotransmission systems have been associated with cannabis consumption during pregnancy and lactation. In spite of the evidences pointing out the negative behavioral and neurobiological consequences of cannabis use in pregnant and breastfeeding women, there are still limitations to identify biomarkers that could help to establish preventive or therapeutic approaches. It is difficult to define the direct association specifically with cannabis, avoiding other confusing factors, co-occurrence of other drugs consumption (mainly nicotine and alcohol), lifestyle, or socioeconomic factors. Therefore, it is necessary to progress in the characterization of short-and long-term cannabis exposure-related disturbances.

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Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy

Cited by 104 publications

References 30 publications

Perinatal THC exposure via lactation induces lasting alterations to social behavior and prefrontal cortex function in rats at adulthood

Perinatal THC exposure via lactation induces lasting alterations to social behavior and prefrontal cortex function in rats at adulthood

Perinatal THC Exposure via Lactation Induces Lasting Alterations to Social Behavior and Prefrontal Cortex Function in Rats at Adulthood

Cannabis Use in Pregnant and Breastfeeding Women: Behavioral and Neurobiological Consequences

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