Self‐reported cognitive outcomes among adolescent and young adult patients with noncentral nervous system cancers

Tan, Chia Jie; Mah, Jaclyn Jia Jun; Goh, Wei Lin; Poon, Eileen; Rashid, Mohamad Farid Harunal; Chan, Alexandre

doi:10.1002/pon.5456

Cited by 18 publications

(32 citation statements)

References 31 publications

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“…This is a common observation. Up to 53% of AYA cancer survivors report treatment-related cognitive dysfunction, which may persist for up to 25 years post-diagnosis [ 7 , 14 , 40 ]. This seems to be caused by unique neurological processes in young adulthood.…”

Section: Discussionmentioning

confidence: 99%

Work ability and cognitive impairments in young adult cancer patients: associated factors and changes over time—results from the AYA-Leipzig study

et al. 2021

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Purpose Although young adults represent a significant portion of the working population, little is known about the work ability and cognitive impairments in adolescent and young adult (AYA) cancer patients (including the long-term course) following cancer treatment. Methods As part of the AYA-Leipzig study, we surveyed AYA cancer survivors (aged 18–39 years at diagnosis; time since diagnosis ≤ 4 years, including all cancer diagnoses) at two time points (t2 = 12 months after t1). Work ability (Work Ability Index, WAI-r) and cognitive impairments (Copenhagen Psychosocial Questionnaire, COPSOQ) were compared at both time points. We analysed predictors for work ability at, on average, 2 years post cancer diagnosis (t2) by using multivariate regression analyses. Results A total of 502 patients (74.7% women) participated in both measurements. Mean work ability increased significantly from t1 (6.0; SD = 2.3) to t2 (6.8; SD = 2.2) (t = −9.3; p < 0.001). As many as 380 (76%) AYA cancer survivors reported reduced work ability at t1; 1 year later, this still applied to 287 (57%) of them. Decreased work ability (t2) was associated with more cognitive impairment, higher effort coping with the disease, comorbidities, sick leave > 6 months (since diagnosis), and having children (adj R2 = .48). Cognitive impairments occurred in approximately every fifth patient at both surveys. Conclusions Achieving maximum work ability is a major challenge for AYAs. Our results show the need for multimodal cancer survivorship and rehabilitation programmes with a special focus on improving cognitive and psychosocial functioning. Implications for Cancer Survivors AYAs with cancer should receive targeted occupational counselling early in the course of the disease.

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Section: Discussionmentioning

confidence: 99%

Work ability and cognitive impairments in young adult cancer patients: associated factors and changes over time—results from the AYA-Leipzig study

et al. 2021

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“…All studies comparing outcomes by gender reported a higher rate of self-reported CRCI among females. 33,34,37,42,44 Female AYA lymphoma survivors exhibited significantly more CRCI than males, 33 and females scored significantly higher on the negative Impact of Cancer…”

Section: Gendermentioning

confidence: 99%

“…34 Other studies also report higher CRCI associated with being female. 37,42,44 3.3.4 | Comorbidities CRCI was associated with several comorbid conditions, most frequently fatigue and mental illness. 31,33,34,38,40,44 Husson et al 33,34 found that self-reported CRCI was associated with having physical fatigue or having two or more comorbid health conditions, such as diabetes or asthma.…”

Section: Gendermentioning

confidence: 99%

“…37,42,44 3.3.4 | Comorbidities CRCI was associated with several comorbid conditions, most frequently fatigue and mental illness. 31,33,34,38,40,44 Husson et al 33,34 found that self-reported CRCI was associated with having physical fatigue or having two or more comorbid health conditions, such as diabetes or asthma. Similarly, Nowe et al 37 reported an association between self-reported CRCI and comorbidities.…”

Section: Gendermentioning

confidence: 99%

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Cancer‐related cognitive impairment in survivors of adolescent and young adult non‐central nervous system cancer: A scoping review

2022

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Objectives Cancer‐related cognitive impairments (CRCI) are common after treatment and can have important impacts on the lives of adolescent and young adult (AYA) cancer survivors—those cancer survivors diagnosed between ages 15 and 39. However, most research focuses on survivors diagnosed under age 15 or over age 39 so we know relatively little about CRCI among AYA survivors of non‐central nervous system (CNS) cancers. Here we review the research on CRCI among AYA survivors of non‐CNS cancers to determine prevalence, associated factors, and impact on survivors' lives as well as implications for future research. Methods In November 2021 we performed a systematic search of the literature in MEDLINE, Web of Science, PsycInfo, CINAHL, EMBASE, and Cochrane Central Register of Controlled Trials to identify peer‐reviewed English language articles describing original research with at least one cognitive outcome and conducted with AYA survivors of non‐CNS cancer diagnosed as AYAs. We screened 6003 articles and 21 met eligibility criteria. Guided by the PRISMA‐ScR Checklist, we extracted study information to meet review objectives. Results Most studies employed cross‐sectional surveys or interviews, though some employed longitudinal methods, neurocognitive assessments, or brain imaging. From the subset of articles that reported a prevalence we calculated a weighted mean prevalence of 25.75% and weighted median prevalence of 27.8%. The factors associated with CRCI included female gender, higher dose chemotherapy, and comorbidities. CRCI impacted the lives of AYA survivors through impaired role functioning, financial toxicity, and unmet needs. Conclusions CRCI is highly prevalent among non‐CNS cancer survivors diagnosed as AYAs and impacts quality of life and role functioning. This review suggests a need for further longitudinal, imaging, and mixed methods research and provision of resources to help achieve better quality of life and educational and occupational attainment during what is potentially a decades‐long survivorship period. However, although interventions might improve cognition and functioning, the review identified only one pilot study. Digital interventions may be a practical and effective option for this age group, but they have yet to be adequately investigated.

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“…2 Among AYA cancer patients, cancer-related cognitive impairment (CRCI) was previously self-reported at least once within 12 months after cancer diagnosis. 3,4 This may result in problems with memory, task efficiency, and organization. 5 CRCI can lead to decreased quality of life (QOL), difficulty with job attainment, and poor psychosocial outcomes in survivors.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Cognitive Training to Promote Recovery in Cancer-Related Cognitive Impairment in Adolescent and Young Adult Patients

Gooch

Mehta

John

et al. 2022

Journal of Adolescent and Young Adult Oncology

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Background:Computer-based cognitive rehabilitation programs may help adolescent and young adult (AYA) patients with cancer-related cognitive impairment. This pilot study investigated the feasibility of cognitive rehabilitation as a preventive intervention for AYA patients receiving chemotherapy. Explorative objectives included the correlation of cognitive performance with serum brain-derived neurotrophic factor (BDNF). Methods: This pilot prospective study included English-speaking patients 12-25 years of age with a fist diagnosis of cancer requiring chemotherapy. Participants enrolled in the intervention arm participated in a computer-based neurocognitive training program for 20-30 minutes daily for 16 weeks. Outcome measures, including engagement with and completion of computerized neurocognitive testing and serum BDNF levels, were obtained within the first month following diagnosis, ∼16 and 24 weeks from enrollment.Results: Fourteen of 18 eligible patients provided consent, with 7 patients assigned to each the intervention arm and nonintervention arm. Seventy-one percent of the patients in the intervention arm completed at least 80% of the required activities. Compared to baseline, patients in the nonintervention arm demonstrated higher prevalence of impairment in four of the six cognitive domains (processing speed, visual attention, attention/working memory, and executive function) at the end of the study period. There was a nonstatistically significant reduction of serum BDNF levels over time, which was observed in both intervention and nonintervention arms. Conclusion:This pilot study provides some evidence that it is feasible for AYAs with new cancer diagnoses to receive standardized cognitive rehabilitation. Patients receiving cognitive activities experienced less impairment in numerous cognitive domains.

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Self‐reported cognitive outcomes among adolescent and young adult patients with noncentral nervous system cancers

Cited by 18 publications

References 31 publications

Work ability and cognitive impairments in young adult cancer patients: associated factors and changes over time—results from the AYA-Leipzig study

Work ability and cognitive impairments in young adult cancer patients: associated factors and changes over time—results from the AYA-Leipzig study

Cancer‐related cognitive impairment in survivors of adolescent and young adult non‐central nervous system cancer: A scoping review

Feasibility of Cognitive Training to Promote Recovery in Cancer-Related Cognitive Impairment in Adolescent and Young Adult Patients

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