Self-Reported Cognitive Functioning in Formerly Eclamptic Women

Aukes, Annet M.; Wessel, Ineke; Dubois, Albertien M.; Aarnoudse, Jan G.; Zeeman, Gerda G.

doi:10.1097/01.ogx.0000300466.36604.7b

Cited by 34 publications

(45 citation statements)

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“…Studies have suggested that hypertensive pregnancy disorders have an increased, sex-specific risk of cognitive decline and dementia among women 5 to 10 years after the hypertensive pregnancy (Aukes et al 2007;Postma et al 2014a;. Moreover, a recent study has shown that hypertensive pregnancy disorders are associated with worse performance in tests of processing speed and smaller brain volumes decades later, when compared with women with histories of normotensive pregnancies (Mielke et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice

Wang

Chen

et al. 2016

AGE

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Data shows that inflammation during pregnancy significantly exerts a long-term influence on offspring, such as increasing the risk of adult cognition decline in animals. However, it is unclear whether gestational inflammation affects the neurobehavioral and neurobiochemical outcomes in the motherself during aging. In this study, pregnant CD-1 mice intraperitoneally received lipopolysaccharide (LPS) in two doses (25 and 50 g/kg, respectively) or normal saline daily during gestational days 15-17. At the age of 15 months, a battery of behavioral tasks was employed to evaluate their species-typical behaviors, sensorimotor ability, anxiety levels, and spatial learning and memory abilities. An immunohistochemical method was utilized preliminarily to detect neurobiochemical indicators consisting of amyloid-β, p h o s p h o r y l a t e d t a u , p r e s y n a p t i c p r o t e i n s synaptotagmin-1 and syntaxin-1, glial fibrillary acidic protein (GFAP), and histone-4 acetylation on the K8 site (H4K8ac). The behavioral results showed that LPS exposure during pregnancy exacerbated a decline in 15-month-old CD-1 mice's abilities to nest, their sensorimotor and spatial learning and memory capabilities, and increased their anxiety levels. The neurobiochemical results indicated that gestational LPS exposure also intensified age-related hippocampal changes, including increased amyloid-β 42 , phosphorylated tau, synaptotagmin-1 and GFAP, and decreased syntaxin-1 and H4K8ac. Our results suggested that the inflammatory insult during pregnancy could be an important risk factor for the development of Alzheimer's disease, and the H4K8 acetylation might play an important role in the underlying mechanism. This study offers a perspective for improving strategies that support healthy development and successful aging.

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Section: Introductionmentioning

confidence: 99%

Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice

Wang

Chen

et al. 2016

AGE

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“…Women who were admitted with pre-eclampsia between 1988 and 2005 were selected and matched for age and year of index pregnancy (both within 2 years) with women who experienced eclampsia, who have been reported in previous studies. 3,8 These formerly pre-eclamptic women were invited to participate in the current study by mail. In addition to this group, all women admitted to obstetric high care with severe pre-eclampsia and/or with HELLP syndrome (haemolysis, elevated liver enzymes, low platelets) over a 2-year period (1 January 2005 to 31 December 2006) were invited by mail to participate.…”

Section: Study Participantsmentioning

confidence: 99%

Long‐term cerebral imaging after pre‐eclampsia

Aukes

Groot

Wiegman

et al. 2012

BJOG

108

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Objective Formerly eclamptic women demonstrate cerebral white matter lesions (WMLs) several years following the index pregnancy. The pathophysiology is unclear and may be related to the predisposition for cerebrovascular/cardiovascular disease in such women and/or the occurrence of posterior reversible encephalopathy syndrome whilst pregnant. The aim of this study was to assess the presence and severity of WMLs and their relationship with the severity of the neurological symptoms during the index pregnancy and several current cardiovascular risk factors in formerly pre-eclamptic women.Design This was a retrospective cohort study.Setting The Neuroimaging Centre at the School for Behavioural and Cognitive Neurosciences, Groningen, the Netherlands.Population Seventy-three formerly pre-eclamptic women were matched for age (37 ± 6 years) and elapsed time since index pregnancy (5.1 ± 3.7 years) with parous control women.Methods Cerebral magnetic resonance imaging scans were performed on cases and controls. Scans were rated by a neuroradiologist blind to the patient category.Main outcome measures The presence and severity of cerebral WMLs.Results Formerly pre-eclamptic women had WMLs significantly more often (37%) and more severely (mean, 0.11; median, 0.00; range, 0-2.34 ml) than controls (21%, P = 0.04; mean, 0.015; median, 0.00; range, 0-0.13 ml; P = 0.02). Current hypertension and a history of early-onset pre-eclampsia (<37 weeks) were independently associated with the presence of WMLs (b = 1.34, P = 0.02 and b = 1.73, P = 0.01, respectively).Conclusions Our findings indicate that pre-eclampsia might be a risk marker for early cerebrovascular damage. The predisposition of formerly pre-eclamptic women to later cardiovascular and cerebrovascular disease may be an important factor for the development of cerebral WMLs. Whether a history of posterior reversible encephalopathy syndrome may be an additive risk factor for the development of these lesions remains unknown.

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“…2 A small proportion of patients with preeclampsia go on to develop eclampsia (0.5%-3%), 3,4 which has been associated with persistent visual and neurological sequelae that may carry long-term consequences for the mother. [5][6][7][8] Forty percent of deaths from eclampsia are thought to be preventable. 9 The guidelines recommend the use of magnesium sulfate (MgSO 4 ) for prophylaxis in patients with severe preeclampsia (I-A 10,11 ) and for the treatment of eclampsia (I-A).…”

Section: Introductionmentioning

confidence: 99%

Magnesium sulfate for eclampsia prevention: Quality of care evaluation in a tertiary centre in Québec, Canada

et al. 2014

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Background: The current Canadian guidelines endorse the use of MgSO 4 for treatment of eclampsia and for prophylaxis in severe preeclampsia.Our study aimed to audit our institution's compliance regarding these guidelines. Methods:We conducted a retrospective study to evaluate MgSO 4 use in: all our cases of eclampsia since 2002, 50 cases of severe preeclampsia, and 50 cases of non-severe preeclampsia.Results: Sixty-five cases of preeclampsia were analyzed after initial chart review. A high rate of preeclampsia severity misdiagnosis was observed (35%, 23/65). Only 69% (25/36) of the patients correctly diagnosed with severe preeclampsia received MgSO 4 ; after diagnosis correction, 42% (25/59) of the patients with severe preeclampsia received the medication. Of our eight cases of eclampsia, none of the patients received MgSO 4 before the seizure (although three had clear indications). Conclusion:Given the importance of prophylactic MgSO 4 use in preventing eclampsia, we have implemented informative measures aimed at rapidly achieving complete compliance with the national guidelines.

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Self-Reported Cognitive Functioning in Formerly Eclamptic Women

Cited by 34 publications

References 0 publications

Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice

Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice

Long‐term cerebral imaging after pre‐eclampsia

Magnesium sulfate for eclampsia prevention: Quality of care evaluation in a tertiary centre in Québec, Canada

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