Self-reported cannabis use is inconsistent with the results from drug-screening in youth at ultra high-risk for psychosis in Colorado

Carol, Emily E.; Mittal, Vijay A.

doi:10.1016/j.schres.2014.05.032

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…Some limitations of the present study should be noted. First, a recent study comparing self-reported drug use in UHR individuals with urine drug screens revealed both over- and under-reporting of cannabis use (Carol & Mittal, 2014). This raises concern regarding the validity of self-reported cannabis use in the present study, especially where individuals were recalling patterns and characteristics of use from several years prior.…”

Section: Discussionmentioning

confidence: 99%

Cannabis-induced attenuated psychotic symptoms: implications for prognosis in young people at ultra-high risk for psychosis

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Cannabis-induced attenuated psychotic symptoms: implications for prognosis in young people at ultra-high risk for psychosis

et al. 2016

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“…The self-report ascertainment of cannabis use may be less reliable gathering biologically based metrics such as urine toxicology data to verify cannabis use. A recent study evaluating concordance between urine screening and self-reported cannabis use in youth at risk for psychosis has shown inconsistencies between urine results and self-reported use, such that some people reported cannabis usage but urine screens were negative, whereas others did not report cannabis use but urine screens were positive for tetrahydrocannabinol (Carol and Mittal, 2014). Further, details on cannabis dosage or potency were not collected and therefore their potential impact on subcortical structure cannot be determined.…”

Section: Discussionmentioning

confidence: 99%

Relation between cannabis use and subcortical volumes in people at clinical high risk of psychosis

Buchy

Mathalon²,

Cannon

et al. 2016

Psychiatry Research: Neuroimaging

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Among people at genetic risk of schizophrenia, those who use cannabis show smaller thalamic and hippocampal volumes. We evaluated this relationship in people at clinical high risk (CHR) of psychosis. The Alcohol and Drug Use Scale was used to identify 132 CHR cannabis users, the majority of whom were non-dependent cannabis users, 387 CHR non-users, and 204 healthy control non-users, and all participants completed magnetic resonance imaging scans. Volumes of the thalamus, hippocampus and amygdala were extracted with FreeSurfer, and compared across groups. Comparing all CHR participants with healthy control participants revealed no significant differences in volumes of any ROI. However, when comparing CHR users to CHR non-users, a significant ROI × Cannabis group effect emerged: CHR users showed significantly smaller amygdala compared to CHR non-users. However, when limiting analysis to CHR subjects who reported using alcohol at a ‘use without impairment’ severity level, the amygdala effect was non-significant; rather, smaller hippocampal volumes were seen in CHR cannabis users compared to non-users. Controlling statistically for effects of alcohol and tobacco use rendered all results non-significant. These results highlight the importance of controlling for residual confounding effects of other substance use when examining the relationship between cannabis use and neural structure.

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“…Cannabis use was defined by the presence of THC in a urine screen and also by self-reported use of cannabis in the past month; both assessment strategies were employed to capture a range of more immediate and then longer-term use, respectively. Further, the urine panel helped to address concerns about over or under reporting (Carol and Mittal, 2014) and the self-report measure provided detailed data about frequency that was not possible to determine with the urine panel alone.…”

Section: Methodsmentioning

confidence: 99%

The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis

Carol

Spencer

Mittal

2017

Psychoneuroendocrinology

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Recent studies have posited a relationship between cannabis use and the biological stress system, but this critical relationship has not been evaluated during the ultra high-risk (UHR) period immediately preceding the onset of psychotic disorders. Salivary cortisol samples were collected on 46 UHR and 29 control adolescents; these individuals were assessed for current cannabis use with a urine panel and self-report. UHR participants where separated into two groups: Current Cannabis Use (UHR-CU) and No Current Cannabis Use (UHR-NC). Healthy Control participants (HC) were free of cannabis use. Consistent with the literature, results indicate UHR individuals showed elevated cortisol levels when compared to HC participants. Further, we also observed that UHR-CU participants exhibited elevated levels when compared to both the non-using UHR and HC groups. Findings suggest that cannabis use may interact with underlying biological vulnerability associated with the hypothalamic-pituitary-adrenal (HPA) axis system.

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Self-reported cannabis use is inconsistent with the results from drug-screening in youth at ultra high-risk for psychosis in Colorado

Cited by 8 publications

References 8 publications

Cannabis-induced attenuated psychotic symptoms: implications for prognosis in young people at ultra-high risk for psychosis

Cannabis-induced attenuated psychotic symptoms: implications for prognosis in young people at ultra-high risk for psychosis

Relation between cannabis use and subcortical volumes in people at clinical high risk of psychosis

The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis

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