Parkinson's disease (PD) is one of the common neurodegenerative diseases, with more than 10 million confirmed cases of PD estimated worldwide by 2040. 1 Tremor, rigidity, and bradykinesia are typical clinical manifestations of PD. 2 Non-motor symptoms include gastrointestinal dysfunction, such as constipation, sleep behavior disorder, depression, and cognitive impairment. 3 Importantly, nonmotor symptoms and motor symptoms might influence each other to aggravate PD severity, 4 thereby exacerbating the deterioration of quality of life and mentality in patients with PD.The pathogenesis of PD is complex, which is mainly related to complex environmental factors. A large number of epidemiological studies indicated that the prevalence of PD was higher in people over 50 years old, and the incidence increased with age. 5 The prevalence of PD was higher in men than that in women at the same age. 6 However, there were significant differences in PD prevalence among different regions and races in different studies. [7][8][9] In addition,