Self-Reported Allergy to Thyroid Replacement Therapy: A Multicenter Retrospective Chart Review

Chamorro-Pareja, Natalia; Carrillo-Martín, Ismael; Haehn, Daniela A.; Westphal, Sydney A.; Park, Miguel A.; Bernet, Victor; Gonzalez‐Estrada, Alexei

doi:10.4158/ep-2019-0488

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Other hypersensitivity reactions to levothyroxine include angioedema, eczematiform skin eruptions, and pruritus. 5 To date, there is limited information on whether levothyroxine hypersensitivity reaction is IgE-mediated or non-Ig-E-mediated. 6 It is recommended to perform skin testing but this was only reported in certain cases.…”

Section: Discussionmentioning

confidence: 99%

“…Most patients with hypersensitivity reaction tolerated an alternative thyroxine preparation without further reaction, supporting the theory that the allergy is likely due to the excipients or fillers rather than the thyroid hormone itself. 5 Thus, a trial of switching the patient to an alternative levothyroxine preparation is usually done. This was not successful with our patient and the gel capsule formulation which has the least excipients was not available locally.…”

Section: Discussionmentioning

confidence: 99%

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Successful Oral Levothyroxine Desensitization in a Patient with Severe Hypothyroidism Post Radioactive Iodine Therapy: A Case Report

Chua

Shen

Yun

et al. 2021

JAFES

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Levothyroxine remains the standard therapy for patients with hypothyroidism worldwide. Levothyroxine allergy is rarely seen and alternative therapies are less efficacious and scarcely available. The use of liothyronine (LT3) monotherapy is less favoured due to its short half-life and unpredictable pharmacological profile. We report a 59-year-old male with a hypersensitivity reaction to levothyroxine who was successfully desensitized with oral levothyroxine within a day using a 14-step protocol (Table 1).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Successful Oral Levothyroxine Desensitization in a Patient with Severe Hypothyroidism Post Radioactive Iodine Therapy: A Case Report

Chua

Shen

Yun

et al. 2021

JAFES

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“…L‐thyroxin was used as a thyroid replacement therapy for hypothyroidism. However, excessive use of L‐thyroxin could lead to hyperthyroidism, 28 which increased the metabolic rate and caused symptoms, including sweating, anxiety, tachycardia, and tremors 29,30 . This can be blocked by discontinuing the use of L‐thyroxin or using β–blockers, such as propranolol, atenolol, and metoprolol 31 .…”

Section: Introductionmentioning

confidence: 99%

New hope for Parkinson's disease treatment: Targeting gut microbiota

2022

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Parkinson's disease (PD) is one of the common neurodegenerative diseases, with more than 10 million confirmed cases of PD estimated worldwide by 2040. 1 Tremor, rigidity, and bradykinesia are typical clinical manifestations of PD. 2 Non-motor symptoms include gastrointestinal dysfunction, such as constipation, sleep behavior disorder, depression, and cognitive impairment. 3 Importantly, nonmotor symptoms and motor symptoms might influence each other to aggravate PD severity, 4 thereby exacerbating the deterioration of quality of life and mentality in patients with PD.The pathogenesis of PD is complex, which is mainly related to complex environmental factors. A large number of epidemiological studies indicated that the prevalence of PD was higher in people over 50 years old, and the incidence increased with age. 5 The prevalence of PD was higher in men than that in women at the same age. 6 However, there were significant differences in PD prevalence among different regions and races in different studies. [7][8][9] In addition,

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A tale of two patients with hypersensitivity reactions to levothyroxine

Gansert

Garzon-Siatoya

Morgenstern-Kaplan

et al. 2022

QJM: An International Journal of Medicine

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Hypothyroidism is common in the general population, and levothyroxine (LT4) is the treatment of choice. LT4 is well tolerated in the majority of the patients, and allergic reactions are rare, with only a few reported cases of LT4 drug hypersensitivity reactions (DHR) 1–3; However, due to the synthetic nature of this drug, it is suggested that hypersensitivity can be induced under certain pathologic conditions, such as autoimmune disorders 4. We present two cases of DHR to thyroid replacement therapy (TRT) with subsequent management by drug provocation test (DPT) and induction of drug tolerance (IDT).

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Self-Reported Allergy to Thyroid Replacement Therapy: A Multicenter Retrospective Chart Review

Cited by 3 publications

References 18 publications

Successful Oral Levothyroxine Desensitization in a Patient with Severe Hypothyroidism Post Radioactive Iodine Therapy: A Case Report

Successful Oral Levothyroxine Desensitization in a Patient with Severe Hypothyroidism Post Radioactive Iodine Therapy: A Case Report

New hope for Parkinson's disease treatment: Targeting gut microbiota

A tale of two patients with hypersensitivity reactions to levothyroxine

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