Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways

Filiberti, Serena; Russo, Mariapia; Lonardi, Silvia; Bugatti, Mattia; Vermi, William; Tournier, Cathy; Giurisato, Emanuele

doi:10.3390/biomedicines10112709

Cited by 8 publications

(7 citation statements)

References 176 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, c-Maf controls the inhibitory activity of TAMs because it is strongly upregulated in these cells. 222 Research from Liu et al 221 confirmed that tumor load is decreased alongside improved anticancer T cell immunity after selective elimination of c-Maf in myeloid cells. The researchers also found that in a model of subcutaneous LLC tumors, blocking c-Maf partially removes resistance to anti-PD-1 treatment.…”

Section: Ifn Regulatory Factorsmentioning

confidence: 97%

Macrophages in immunoregulation and therapeutics

Chen

Saeed

Liu

et al. 2023

Sig Transduct Target Ther

286

107

View full text Add to dashboard Cite

Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers. Macrophages possess binary M1/M2 macrophage polarization settings, which perform a central role in an array of immune tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered. In addition, the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology. Moreover, they are an integral part of the tumor microenvironment, playing a part in the regulation of a wide variety of processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, and resistance to chemotherapeutic and checkpoint blockade immunotherapies. Herein, we discuss immune regulation in macrophage polarization and signaling, mechanical stresses and modulation, metabolic signaling pathways, mitochondrial and transcriptional, and epigenetic regulation. Furthermore, we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions. Moreover, we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis. Lastly, we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases.

show abstract

Section: Ifn Regulatory Factorsmentioning

confidence: 97%

Macrophages in immunoregulation and therapeutics

Chen

Saeed

Liu

et al. 2023

Sig Transduct Target Ther

286

107

View full text Add to dashboard Cite

show abstract

“…Macrophages and macrophage-like cells, such as dendritic cells, microglia, and osteoclasts, also rely on vesicular trafficking for fighting infections, general housekeeping functions and for tumors. A 2A R-mediated signaling plays an important role in the self-renewal of macrophages in the tumor microenvironment [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Adenosine A2A Receptor Activation Regulates Niemann–Pick C1 Expression and Localization in Macrophages

Skopál,

Ujlaki,

Gerencsér

et al. 2023

CIMB

View full text Add to dashboard Cite

Adenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann–Pick type C intracellular cholesterol transporter 1 (NPC1) protein. The NPC1 protein was identified to interact with the C-terminal tail of A2AR in RAW 264.7 and IPMФ cells by two independent and parallel proteomic approaches. The interaction between the NPC1 protein and the full-length A2AR was further validated in HEK-293 cells that permanently express the receptor and RAW264.7 cells that endogenously express A2AR. A2AR activation reduces the expression of NPC1 mRNA and protein density in LPS-activated mouse IPMФ cells. Additionally, stimulation of A2AR negatively regulates the cell surface expression of NPC1 in LPS-stimulated macrophages. Furthermore, stimulation of A2AR also altered the density of lysosome-associated membrane protein 2 (LAMP2) and early endosome antigen 1 (EEA1), two endosomal markers associated with the NPC1 protein. Collectively, these results suggested a putative A2AR-mediated regulation of NPC1 protein function in macrophages, potentially relevant for the Niemann–Pick type C disease when mutations in NPC1 protein result in the accumulation of cholesterol and other lipids in lysosomes.

show abstract

“…The communication between the tumor, stromal and immune cells in the tumor microenvironment (TME) is necessary for the establishment of an environment that is suitable for tumor cell growth [33], proliferation and invasion of secondary tissues [34]. In this scenario, CSF-1R ligands, IL-34 and M-CSF, play an important role in the crosstalk between immune and tumor cells, as, in fact, immune and cancer cells secreted cytokines and interleukins, which supported tumor development and progression [33,35]. In colorectal cancer (CRC), cancer cells secrete IL-34 and express CSF-1R, suggesting the presence of an autocrine positive feedback loop on the receptor.…”

Section: Role Of Csf-1r Ligands In Tme Crosstalkmentioning

confidence: 99%

CSF-1R in Cancer: More than a Myeloid Cell Receptor

Cersosimo,

Lonardi,

Ulivieri

et al. 2024

Cancers

Self Cite

View full text Add to dashboard Cite

Colony-stimulating factor 1 receptor (CFS-1R) is a myeloid receptor with a crucial role in monocyte survival and differentiation. Its overexpression is associated with aggressive tumors characterized by an immunosuppressive microenvironment and poor prognosis. CSF-1R ligands, IL-34 and M-CSF, are produced by many cells in the tumor microenvironment (TME), suggesting a key role for the receptor in the crosstalk between tumor, immune and stromal cells in the TME. Recently, CSF-1R expression was reported in the cell membrane of the cancer cells of different solid tumors, capturing the interest of various research groups interested in investigating the role of this receptor in non-myeloid cells. This review summarizes the current data available on the expression and activity of CSF-1R in different tumor types. Notably, CSF-1R+ cancer cells have been shown to produce CSF-1R ligands, indicating that CSF-1R signaling is positively regulated in an autocrine manner in cancer cells. Recent research demonstrated that CSF-1R signaling enhances cell transformation by supporting tumor cell proliferation, invasion, stemness and drug resistance. In addition, this review covers recent therapeutic strategies, including monoclonal antibodies and small-molecule inhibitors, targeting the CSF-1R and designed to block the pro-oncogenic role of CSF-1R in cancer cells.

show abstract

Self-Renewal of Macrophages: Tumor-Released Factors and Signaling Pathways

Cited by 8 publications

References 176 publications

Macrophages in immunoregulation and therapeutics

Macrophages in immunoregulation and therapeutics

Adenosine A2A Receptor Activation Regulates Niemann–Pick C1 Expression and Localization in Macrophages

CSF-1R in Cancer: More than a Myeloid Cell Receptor

Contact Info

Product

Resources

About