Self-rated aggression and cerebral monoaminergic turnover

Prochazka, Helena; Ågren, Hans

doi:10.1007/s00406-003-0423-8

Cited by 18 publications

(1 citation statement)

References 36 publications

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“…This finding can be attributed to either low sensitivity of the behavioral measures in capturing treatment effects or that the women included in this study were not a highly aggressive sample. The scores in the current sample at baseline and for the SPRM group during treatment (the placebo group had marginally higher mean, see Table 1 ) were lower than the cut-off score for aggressive behavior [ 45 ], as well as than those observed in general (females: 52) and clinical populations (females with persistent depressive disorder: 59) [ 59 ]. SPRM treatment was associated with lower state aggression compared to placebo, although the scores did not correlate with brain reactivity.…”

Section: Discussionmentioning

confidence: 95%

Brain reactivity during aggressive response in women with premenstrual dysphoric disorder treated with a selective progesterone receptor modulator

Kaltsouni

Fisher

Dubol

et al. 2021

Neuropsychopharmacol.

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Premenstrual dysphoric disorder (PMDD) is a psychiatric condition characterized by late luteal phase affective, cognitive, and physical impairment. The disorder causes significant suffering in about 5% of women in their reproductive age. Altered sensitivity of cognitive-affective brain circuits to progesterone and its downstream metabolite allopregnanolone is suggested to underlie PMDD symptomatology. Core mood symptoms include irritability and anger, with aggression being the behavioral outcome of these symptoms. The present study sought to investigate the neural correlates of reactive aggression during the premenstrual phase in women with PMDD, randomized to a selective progesterone receptor modulator (SPRM) or placebo. Self-reports on the Daily Record of Severity of Problems were used to assess PMDD symptoms and gonadal hormone levels were measured by liquid chromatography tandem mass spectrometry. Functional magnetic resonance imaging was performed in 30 women with PMDD, while performing the point subtraction aggression paradigm. Overall, a high SPRM treatment response rate was attained (93%), in comparison with placebo (53.3%). Women with PMDD randomized to SPRM treatment had enhanced brain reactivity in the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex during the aggressive response condition. The fronto-cingulate reactivity during aggressive responses depended on treatment, with a negative relationship between brain reactivity and task-related aggressiveness found in the placebo but not the SPRM group. The findings contribute to define the role of progesterone in PMDD symptomatology, suggesting a beneficial effect of progesterone receptor antagonism, and consequent anovulation, on top-down emotion regulation, i.e., greater fronto-cingulate activity in response to provocation stimuli.

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Section: Discussionmentioning

confidence: 95%