Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1

Zhang, Yingzi; Xu, Lingling; Liu, Zhuo; Cui, Xiaoqin; Xiang, Zhuo; Bai, Jinyu; Jiang, Dongjie; Xue, Jiangtao; Wang, Chan; Lin, Youxi; Li, Zhe; Shan, Yizhu; Yang, Yuan; Bo, Lin; Li, Zhou; Zhou, Xiaozhong

doi:10.1016/j.nanoen.2021.106009

Cited by 59 publications

(41 citation statements)

References 35 publications

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“…Therefore, its application is similar to that of a TENG and it too can be used as a self-powered electrical stimulation source. For example, Zhang et al proposed a biomechanical energy-driven shape-memory PENG for promoting MC3T3-E1 cell proliferation and orientation and osteogenic differentiation [67]. Jin et al designed a tribo/piezoelectric hybrid nanogenerator to promote the long-term proliferation and migration of Schwann cells and regenerate the myelination of nerve fibers and neuromotor function reconstruction [68].…”

Section: Pengs For Cell Modulationmentioning

confidence: 99%

Electromechanical Nanogenerators for Cell Modulation

Liu

Wang

2022

Nanoenergy Advances

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Bioelectricity is an indispensable part of organisms and plays a vital role in cell modulation and tissue/organ development. The development of convenient and bio-safe electrical stimulation equipment to simulate endogenous bioelectricity for cell function modulation is of great significance for its clinical transformation. In this review, we introduce the advantages of an electromechanical nanogenerator (EMNG) as a source of electrical stimulation in the biomedical field and systematically overview recent advances in EMNGs for cell modulation, mainly including cell adhesion, migration, proliferation and differentiation. Finally, we emphasize the significance of self-powered and biomimetic electrostimulation in cell modulation and discuss its challenges and future prospects in both basic research and clinical translation.

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Section: Pengs For Cell Modulationmentioning

confidence: 99%

Electromechanical Nanogenerators for Cell Modulation

Liu

Wang

2022

Nanoenergy Advances

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“…Harvesting waste mechanical energy from the environment could be a potential solution to solve the energy crisis. [ 1 ] Also, mechanical energy is one of the important renewable and sustainable energy resources, and it is enormously distributed in the living environment in different forms. [ 2–5 ] Among them, energy harvesting from human mechanical motions (such as clapping, finger tapping, running, walking, jumping, punching, etc.)…”

Section: Introductionmentioning

confidence: 99%

High‐Efficiency Poly(Vinylidene Fluoride‐Co‐Hexafluoropropylene) Loaded 3D Marigold Flower‐Like Bismuth Tungstate Triboelectric Films for Mechanical Energy Harvesting and Sensing Applications

Manchi

Graham

Patnam

et al. 2022

Small

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Triboelectric nanogenerators (TENGs) are one of the most trending energy harvesting devices because of their efficient and simple mechanism in harvesting mechanical energy from the environment into electricity. Herein, ferroelectric and dielectric bismuth tungstate (Bi2WO6 (BWO)) with a marigold flower‐like structure is prepared via a hydrothermal method, which is embedded in poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP), forming a PVDF‐HFP/BWO composite polymer film (CPF) to fabricate TENGs. Generally, the ferroelectric materials exhibit a large piezoelectric coefficient, high electrostatic dipole moment, and high dielectric constant. The prepared PVDF‐HFP/BWO CPF reveals a high polar crystalline β‐phase which leads to enhanced piezoelectric and ferroelectric properties of the CPF, thus resulting in the increased electrical performance of the fabricated TENG. The electrical output performance of the proposed TENG is systematically investigated by varying the amount of BWO material embedded in the PVDF‐HFP polymer. The fabricated PVDF‐HFP/2.5 wt% BWO CPF‐based TENG device exhibits the highest electrical output performance. Additionally, the robust test of the TENG device is conducted to investigate the electrical performance for long‐term durability and mechanical stability. Finally, the proposed TENG is operated as a self‐powered sensor, harvesting mechanical energy from daily life human activities, and powering various low‐power portable electronics.

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“…Along with mechanical stimulations, electrical stimulations have also been studied to promote bone regeneration, and it is currently administered by using three different approaches: direct current (DC) (Khaw et al, 2021; Srirussamee et al, 2021; Y. Zhang et al, 2021), pulsed electromagnetic field (PEMF) (Benya et al, 2021; Diniz et al, 2002; Dong et al, 2021), and capacitive coupled (CC) (Chalidis et al, 2011). The main problems affecting the application of these methods in vitro are due to the lack of standardization of cell types, models and protocols, the high risk of contamination, and the invasiveness and high costs of the surgical procedures that would follow in vivo (Bhavsar et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design, fabrication, and characterization of a multimodal reconfigurable bioreactor for bone tissue engineering

Montorsi

Genchi

Pasquale

et al. 2022

Biotech & Bioengineering

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In the past decades, bone tissue engineering developed and exploited many typologies of bioreactors, which, besides providing proper culture conditions, aimed at integrating those bio‐physical stimulations that cells experience in vivo, to promote osteogenic differentiation. Nevertheless, the highly challenging combination and deployment of many stimulation systems into a single bioreactor led to the generation of several unimodal bioreactors, investigating one or at mostly two of the required biophysical stimuli. These systems miss the physiological mimicry of bone cells environment, and often produced contrasting results, thus making the knowledge of bone mechanotransduction fragmented and often inconsistent. To overcome this issue, in this study we developed a perfusion and electroactive‐vibrational reconfigurable stimulation bioreactor to investigate the differentiation of SaOS‐2 bone‐derived cells, hosting a piezoelectric nanocomposite membrane as cell culture substrate. This multimodal perfusion bioreactor is designed based on a numerical (finite element) model aimed at assessing the possibility to induce membrane nano‐scaled vibrations (with ~12 nm amplitude at a frequency of 939 kHz) during perfusion (featuring 1.46 dyn cm−2 wall shear stress), large enough for inducing a physiologically‐relevant electric output (in the order of 10 mV on average) on the membrane surface. This study explored the effects of different stimuli individually, enabling to switch on one stimulation at a time, and then to combine them to induce a faster bone matrix deposition rate. Biological results demonstrate that the multimodal configuration is the most effective in inducing SaOS‐2 cell differentiation, leading to 20‐fold higher collagen deposition compared to static cultures, and to 1.6‐ and 1.2‐fold higher deposition than the perfused‐ or vibrated‐only cultures. These promising results can provide tissue engineering scientists with a comprehensive and biomimetic stimulation platform for a better understanding of mechanotransduction phenomena beyond cells differentiation.

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Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1

Cited by 59 publications

References 35 publications

Electromechanical Nanogenerators for Cell Modulation

Electromechanical Nanogenerators for Cell Modulation

High‐Efficiency Poly(Vinylidene Fluoride‐Co‐Hexafluoropropylene) Loaded 3D Marigold Flower‐Like Bismuth Tungstate Triboelectric Films for Mechanical Energy Harvesting and Sensing Applications

Design, fabrication, and characterization of a multimodal reconfigurable bioreactor for bone tissue engineering

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