Self-powered pacemaker based on all-in-one flexible piezoelectric nanogenerator

Zhang, Yuanzheng; Zhou, Liping; Liu, Chengzhe; Gao, Xiangyang; Zhou, Zhen; Duan, Shoupeng; Deng, Qiang; Song, Lingpeng; Jiang, Hong; Yu, Lilei; Guo, Shishang; Zheng, Haiwu

doi:10.1016/j.nanoen.2022.107420

Cited by 25 publications

(21 citation statements)

References 42 publications

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“…For instance, Zhang et al proposed a potassium sodium niobate ceramics nanomaterial-based piezoelectric pacemaker, which could convert the bioenergy of the heart beating into electrical signal output to achieve effective myocardial pacing and conduction system pacing, as schemed in Figure 4A. 82 In addition, in vivo piezoelectric devices can also collect the energy of mechanical movements of organs to supply power for the required tissues. Feng et al designed a novel self-powered system consisting of a triboelectric/piezoelectric nanogenerator and a multifunctional NGC, which could convert respiration-generated biomechanical energy into electrical energy and transmit it to the sciatic nerve defect for promoting nerve regeneration (Figure 4B).…”

Section: Mechanical Movementmentioning

confidence: 99%

Section: Central Nerve Repairmentioning

confidence: 99%

“…), blood flow, middle ear tympanic membrane vibration, and small movements such as cell migration can cause deformation of piezoelectric materials in vivo to further achieve electrical signal output. [79][80][81][82][83] By integrating the mechanical energy of human motion, piezoelectric materials can achieve wireless ES without other power equipment. For instance, Zhang et al proposed a potassium sodium niobate ceramics nanomaterial-based piezoelectric pacemaker, which could convert the bioenergy of the heart beating into electrical signal output to achieve effective myocardial pacing and conduction system pacing, as schemed in Figure 4A.…”

Section: Mechanical Movementmentioning

confidence: 99%

“…Especially, miscellaneous mechanical movements of the human body, including muscle contraction and relaxation (skeletal muscle, heart, etc. ), blood flow, middle ear tympanic membrane vibration, and small movements such as cell migration can cause deformation of piezoelectric materials in vivo to further achieve electrical signal output 79–83 . By integrating the mechanical energy of human motion, piezoelectric materials can achieve wireless ES without other power equipment.…”

Section: External Energy‐driven Piezoelectric Effectsmentioning

confidence: 99%

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Piezoelectric biomaterials for neural tissue engineering

Zhang

Wang

et al. 2023

Smart Medicine

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Nerve injury caused by trauma or iatrogenic trauma can lead to loss of sensory and motor function, resulting in paralysis of patients. Inspired by endogenous bioelectricity and extracellular matrix, various external physical and chemical stimuli have been introduced to treat nerve injury. Benefiting from the self‐power feature and great biocompatibility, piezoelectric biomaterials have attracted widespread attention in biomedical applications, especially in neural tissue engineering. Here, we provide an overview of the development of piezoelectric biomaterials for neural tissue engineering. First, several types of piezoelectric biomaterials are introduced, including inorganic piezoelectric nanomaterials, organic piezoelectric polymers, and their derivates. Then, we focus on the in vitro and in vivo external energy‐driven piezoelectric effects involving ultrasound, mechanical movement, and other external field‐driven piezoelectric effects. Neuroengineering applications of the piezoelectric biomaterials as in vivo grafts for the treatment of central nerve injury and peripheral nerve injury are also discussed and highlighted. Finally, the current challenges and future development of piezoelectric biomaterials for promoting nerve regeneration and treating neurological diseases are presented.

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Section: Mechanical Movementmentioning

confidence: 99%

Section: Central Nerve Repairmentioning

confidence: 99%

Section: Mechanical Movementmentioning

confidence: 99%

Section: External Energy‐driven Piezoelectric Effectsmentioning

confidence: 99%

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Piezoelectric biomaterials for neural tissue engineering

Zhang

Wang

et al. 2023

Smart Medicine

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“…The wireless and battery-free power supply technologies include internal power harvesting and external power transmission. [27] The advanced technology of nanogenerators has provided a great chance to convert biomechanical energy in the human body into electricity for powering biomedical systems for cardiac pacing, [28,29] neuromodulation, [30,31] or optical therapy. [32,33] Inspired by these advances, we developed a wireless self-powered optogenetic system suitable for wireless cardiac sympathetic modulation in awake freely moving canines.…”

Section: Introductionmentioning

confidence: 99%

Wireless Self‐Powered Optogenetic System for Long‐Term Cardiac Neuromodulation to Improve Post‐MI Cardiac Remodeling and Malignant Arrhythmia

et al. 2023

Self Cite

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Autonomic imbalance is an important characteristic of patients after myocardial infarction (MI) and adversely contributes to post‐MI cardiac remodeling and ventricular arrhythmias (VAs). A previous study proved that optogenetic modulation could precisely inhibit cardiac sympathetic hyperactivity and prevent acute ischemia‐induced VAs. Here, a wireless self‐powered optogenetic modulation system is introduced, which achieves long‐term precise cardiac neuromodulation in ambulatory canines. The wireless self‐powered optical system based on a triboelectric nanogenerator is powered by energy harvested from body motion and realized the effective optical illumination that is required for optogenetic neuromodulation (ON). It is further demonstrated that long‐term ON significantly mitigates MI‐induced sympathetic remodeling and hyperactivity, and improves a variety of clinically relevant outcomes such as improves ventricular dysfunction, reduces infarct size, increases electrophysiological stability, and reduces susceptibility to VAs. These novel insights suggest that wireless ON holds translational potential for the clinical treatment of arrhythmia and other cardiovascular diseases related to sympathetic hyperactivity. Moreover, this innovative self‐powered optical system may provide an opportunity to develop implantable/wearable and self‐controllable devices for long‐term optogenetic therapy.

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A Fully Self‐Powered Wearable Leg Movement Sensing System for Human Health Monitoring

Yuan,

Zhang,

Wei

et al. 2023

Advanced Science

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Energy‐autonomous wearable human activity monitoring is imperative for daily healthcare, benefiting from long‐term sustainable uses. Herein, a fully self‐powered wearable system, enabling real‐time monitoring and assessments of human multimodal health parameters including knee joint movement, metabolic energy, locomotion speed, and skin temperature, which are fully self‐powered by highly‐efficient flexible thermoelectric generators (f‐TEGs) is proposed and developed. The wearable system is composed of f‐TEGs, fabric strain sensors, ultra‐low‐power edge computing, and Bluetooth. The f‐TEGs worn on the leg not only harvest energy from body heat and supply power sustainably for the whole monitoring system, but also serve as zero‐power motion sensors to detect limb movement and skin temperature. The fabric strain sensor made by printing PEDOT: PSS on pre‐stretched nylon fiber‐wrapped rubber band enables high‐fidelity and ultralow‐power measurements on highly‐dynamic knee movements. Edge computing is elaborately designed to estimate multimodal health parameters including time‐varying metabolic energy in real‐time, which are wirelessly transmitted via Bluetooth. The whole monitoring system is operated automatically and intelligently, works sustainably in both static and dynamic states, and is fully self‐powered by the f‐TEGs.

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Self-powered pacemaker based on all-in-one flexible piezoelectric nanogenerator

Cited by 25 publications

References 42 publications

Piezoelectric biomaterials for neural tissue engineering

Piezoelectric biomaterials for neural tissue engineering

Wireless Self‐Powered Optogenetic System for Long‐Term Cardiac Neuromodulation to Improve Post‐MI Cardiac Remodeling and Malignant Arrhythmia

A Fully Self‐Powered Wearable Leg Movement Sensing System for Human Health Monitoring

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