Self-powered implantable electrical stimulator for osteoblasts’ proliferation and differentiation

Tian, Jingjing; Shi, Rui; Liu, Zhuo; Ouyang, Han; Yu, Min; Zhao, Chaochao; Zou, Yang; Jiang, Dongjie; Zhang, Jingshuang; Zhou, Li

doi:10.1016/j.nanoen.2019.02.073

Cited by 138 publications

(128 citation statements)

References 38 publications

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“…In recent years, numerous studies have focused on the development of nanogenerators for self-powered systems. Many of these have been applied in biomedical fields and tissue engineering with great success [32][33][34][35][36][37]. In the orthopedic field, osteogenesis has been shown to be stimulated with negative electrical charges with currents between 5 and 100 μA [38].…”

Section: The Application Of Nanogenerators For Osteogenesismentioning

confidence: 99%

“…Jingjing Tian, et al proposed a self-powered electrical system consisting of a triboelectric nanogenerator (TENG) and a flexible interdigitated electrode for osteogenesis in vitro [37]. Aluminum film served as both the friction layer and electrode layer of the fabricated TENG, and the other friction layer of TENG was nanostructured Polytetrafluoroethylene (PTFE) film.…”

Section: The Application Of Nanogenerators For Osteogenesismentioning

confidence: 99%

“…group had better ALP activity and calcium deposition. 2019[37] Al and PTFE films murine calvarial preosteoblastsThe self-powered electrical stimulator promoted cell attachment, proliferation, differentiation and up-regulated the level of intracellular Ca 2+. PENG 2019[36] Zinc oxide (ZnO) human osteoblasts Human osteoblasts had the best cell proliferation on ZnO nanowires grown on titania nanotubes.…”

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confidence: 99%

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The application of nanogenerators and piezoelectricity in osteogenesis

Kao

Chiu

Tsai

et al. 2019

Science and Technology of Advanced Materials

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Bone is a complex organ possessing both physicomechanical and bioelectrochemical properties. In the view of Wolff's Law, bone can respond to mechanical loading and is subsequently reinforced in the areas of stress. Piezoelectricity is one of several mechanical responses of the bone matrix that allows osteocytes, osteoblasts, osteoclasts, and osteoprogenitors to react to changes in their environment. The present review details how osteocytes convert external mechanical stimuli into internal bioelectrical signals and the induction of intercellular cytokines from the standpoint of piezoelectricity. In addition, this review introduces piezoelectric and triboelectric materials used as self-powered electrical generators to promote osteogenic proliferation and differentiation due to their electromechanical properties, which could promote the development of promising applications in tissue engineering and bone regeneration. ARTICLE HISTORY

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Section: The Application Of Nanogenerators For Osteogenesismentioning

confidence: 99%

Section: The Application Of Nanogenerators For Osteogenesismentioning

confidence: 99%

mentioning

confidence: 99%

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The application of nanogenerators and piezoelectricity in osteogenesis

Kao

Chiu

Tsai

et al. 2019

Science and Technology of Advanced Materials

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“…Implantable TENGs have been designed to generate μW-level electricity from regular body movements, which was sufficient to power implantable medical devices (IMDs) such as pacemakers. 30,31 Intriguing interactions between TENG and cell/tissue/organ activities 32,33 were also discovered enabling self-powered therapeutic stimulations. [34][35][36][37] Being aware of the unique advantages of biomechanical energy from respiration, a number of TENGs prototypes were designed and demonstrated, based on which intriguing biomedical applications were implemented.…”

Section: Introductionmentioning

confidence: 99%

Respiration‐driven triboelectric nanogenerators for biomedical applications

Long

Yang

et al. 2020

EcoMat

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As a fundamental and ubiquitous body motion, respiration offers a large amount of biomechanical energy with an average power up to the Watt level through movements of multiple muscles. The energy from respiration featured with excellent stability, accessibility and continuality inspires the design and engineering of biomechanical energy harvesting devices, such as triboelectric nanogenerators (TENGs), to realize human‐powered electronics. This review article is thus dedicated to the emerging respiration‐driven TENG technology, covering fundamentals, applications, and perspectives. Specifically, the human breathing mechanics are first introduced serving as the base for the developments of TENG devices with different configurations. Biomedical applications including electrical energy generation, healthcare monitoring, air filtration, gas sensing, electrostimulation, and powering implantable medical devices are then analyzed focusing on the design‐application relationships. At last, current developments are summarized and critical challenges for driving these intriguing developments toward practical applications are discussed together with promising solutions.

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“…Furthermore, the discovery of piezoelectricity in bone [34][35][36], which has been the most frequently studied tissue, aroused great interest because it seemed to provide an important key to understanding bone physiology. Researchers hypothesized that bone's piezoelectric signal by physical stimulation could regulate bone growth, repair, wound healing, and tissue regeneration [37][38][39]. In addition, piezoelectric biomaterials also have several advantages for use in sensors [40], energy storage [41], energy harvesting, and other areas [42].…”

Section: Introductionmentioning

confidence: 99%

Recent Developments and Prospects of M13- Bacteriophage Based Piezoelectric Energy Harvesting Devices

et al. 2020

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Recently, biocompatible energy harvesting devices have received a great deal of attention for biomedical applications. Among various biomaterials, viruses are expected to be very promising biomaterials for the fabrication of functional devices due to their unique characteristics. While other natural biomaterials have limitations in mass-production, low piezoelectric properties, and surface modification, M13 bacteriophages (phages), which is one type of virus, are likely to overcome these issues with their mass-amplification, self-assembled structure, and genetic modification. Based on these advantages, many researchers have started to develop virus-based energy harvesting devices exhibiting superior properties to previous biomaterial-based devices. To enhance the power of these devices, researchers have tried to modify the surface properties of M13 phages, form biomimetic hierarchical structures, control the dipole alignments, and more. These methods for fabricating virus-based energy harvesting devices can form a powerful strategy to develop high-performance biocompatible energy devices for a wide range of practical applications in the future. In this review, we discuss all these issues in detail.

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Self-powered implantable electrical stimulator for osteoblasts’ proliferation and differentiation

Cited by 138 publications

References 38 publications

The application of nanogenerators and piezoelectricity in osteogenesis

The application of nanogenerators and piezoelectricity in osteogenesis

Respiration‐driven triboelectric nanogenerators for biomedical applications

Recent Developments and Prospects of M13- Bacteriophage Based Piezoelectric Energy Harvesting Devices

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