Self‐Powered Electrically Controlled Drug Release Systems Based on Nanogenerator

Abstract

Precision medicine requires precise regulation of drugs in terms of time, space, and dosage. Exogenous control systems, such as electrical responsiveness, have made great progress. However, wearable or implantable controlled drug release devices still face major challenges due to limitations including limited battery life, large size, and fixed power supply. To overcome these limitations, the fabrication of autonomous devices is available to endure extended periods without reliance on external power sources. As a promising strategy, nanogenerators (NGs) turn body mechanical energy into electricity, powering long‐term drug release. In this review, the current status of drug delivery systems (DDS) is briefly outlined and the importance of self‐driven controlled drug release systems is emphasized. The main types and operational mechanisms of various nanogenerators are introduced. This review also focuses on summarizing the latest progress of self‐powered controlled drug release systems based on nanogenerators (NG‐based CDRs). Additionally, their applications in the field of drug release are introduced in detail. Finally, the existing challenges and future trends of self‐powered NG‐based CDRs are discussed from the perspectives of clinical needs and practical translation.

Bioelectret Materials and Their Bioelectric Effects for Tissue Repair: A Review

“…In the field of nerve repair, these materials are used to manufacture nerve stimulation electrodes to help restore the function of injured nerves , (Figure ). In addition, self-generating materials can also be used to manufacture drug delivery systems − to effectively control the release of biological growth factors and drugs, thus promoting the process of tissue repair. In addition, they can also be used to the manufacture biosensors, , to monitor physiological parameters in living organisms, and to provide information support for medical diagnosis and treatment.…”

Regulating the Distribution and Accumulation of Charged Molecules by Progressive Electroporation for Improved Intracellular Delivery

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