Self-powered dual-mode sensing strategy based on graphdiyne and DNA nanoring for sensitive detection of tumor biomarker

Shi, Jinyue; Liu, Shiyu; Li, Peiyuan; Lin, Yu; Luo, Hongzhen; Wu, Yeyu; Yan, Jun; Huang, Ke-Jing; Tan, Xuecai

doi:10.1016/j.bios.2023.115557

Cited by 27 publications

(5 citation statements)

References 54 publications

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“…The uniform nanopores and stable alkyne bonds in the GDY structure provide abundant active sites and optional reaction routes for its precise functionalization, which is considered as an effective strategy for tuning the electronic, and physicochemical properties of GDY for extraordinary sensing performance. [56,63,64,67,311,312,[314][315][316][317][318][319][320][321][322][323] For example, in 2022, Tung et al [64] reported conductive Hs-GDY nanofilms with uniformly porous structure and considerably inherent softness for on-skin sensors that can satisfy the stress minimization and wear discomfort. Figure 14a presents the schematic diagram for the preparation of HsGDY nanofilms, including i) self-assembly and lateral coupling of 1,3,5-trithynylbenzene on the Cu (111); ii) vertical stacking to obtain HsGDY nanofilms and form out-of-plane grain boundaries.…”

Section: Sensorsmentioning

confidence: 99%

Functional Graphdiyne for Emerging Applications: Recent Advances and Future Challenges

Wang,

Pu,

et al. 2023

Adv Funct Materials

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Graphdiyne (GDY) is regarded as an exceptional candidate to meet the growing demand in many fields due to its rich chemical bonds, highly π‐conjugated structure, uniformly distributed pores, large surface area, and high inhomogeneity of charge distribution. The extensive research efforts bring about a rapid expansion of GDY with a variety of functionalities, which significantly enhance performance including photocatalysis, energy, biomedicine, etc. In this review, the synthetic strategies (in situ and ex situ approaches) that are designed to rationally functionalize GDY, including optimizing their nanostructures by surface/interface engineering with dopants or functional groups (heteroatoms/small molecules/macromolecules), and building up hierarchical GDY‐based heterostructures are highlighted. Theoretical calculations on the structural evolution and electronic characteristics after the functionalization of GDY are briefly discussed. With elaborate functionalization and rational structure engineering, functional GDY applied in a variety of emerging applications (e.g., hydrogen evolution reaction, CO2 reduction reaction, nitrogen reduction reaction, energy storage and conversion, nanophotonics, sensors, biomedical applications, etc.) are comprehensively discussed. Finally, challenges and prospects concerning the future development of GDY‐based nanoarchitectures are also presented.

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Section: Sensorsmentioning

confidence: 99%

Functional Graphdiyne for Emerging Applications: Recent Advances and Future Challenges

Wang,

Pu,

et al. 2023

Adv Funct Materials

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“…In contrast to methods that require enzyme assistance, rigorous temperature regulation protocols, and intricate manipulations, these dynamic DNA network amplification techniques overcome these constraints. As a powerful isothermal enzyme-free amplification of DNA, CHA is extensively employed in aptasensors. , It is noteworthy to mention that CHA exhibits superior catalytic efficiency and minimal background noise in comparison to other strategies. , A typical CHA reaction has three functional DNA (fDNA) strands: two hairpin-structured DNA strands utilized to construct the downstream amplification circuit and a trigger DNA (T DNA) strand produced by the upstream circuit . By means of toehold contacts, the trigger DNA strand can initially instigate the loop of DNA hairpin 1 (HP1) to open.…”

Section: Introductionmentioning

confidence: 99%

“Two-in-One” PtPdCu Trimetallic Multifunctional Nanoparticles-Mediated Dual-Signal-Integrated Aptasensor for Ultradetection of Enrofloxacin

Wang,

He,

Liu

et al. 2024

ACS Appl. Mater. Interfaces

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Balancing the accuracy and simplicity of aptasensors is a challenge in their construction. This study addresses this issue by leveraging the remarkable loading capacity and peroxidase-like catalytic activity of PtPdCu trimetallic nanoparticles, which reduces the reliance on precious metals. A dual-signal readout aptasensor for enrofloxacin (ENR) detection is designed, incorporating DNA dynamic network cascade reactions to further amplify the output signal. Exploiting the strong loading capacity of PtPdCu nanoparticles, they are self-assembled with thionine (Thi) to form a signal label capable of generating signals in two independent modes. The label exhibits excellent enzyme-like catalytic activity and enhances electron transfer capabilities. Differential pulse voltammetry (DPV) and square-wave voltammetry (SWV) are employed to independently read signals from the oxidation−reduction reaction of Thi and the catalytic oxidation of hydroquinone (HQ) to benzoquinone (BQ) by H 2 O 2 . The introduced DNA dynamic network cascade reaction modularizes sample processing and electrode surface signal generation, avoiding electrode contamination and efficiently increasing the output of the catalyzed hairpin assembly (CHA) cycle. Under optimized conditions, the developed aptasensor demonstrates detection limits of 0.112 (DPV mode) and 0.0203 pg/mL (SWV mode). Additionally, the sensor successfully detected enrofloxacin in real samples, expanding avenues for designing dual-mode signal amplification strategies.

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“…Therefore, AuNPs are widely applied in the construction of biosensors. Functionalizing GDY with AuNPs for the construction of EBFCs can overcome the low electron transfer rate issue and significantly improve their electrochemical performance. , …”

Section: Introductionmentioning

confidence: 99%

Flexible Self-Powered Sensing System Based on Novel DNA Circuit Strategy and Graphdiyne for Thalassemia Gene by Rapid Naked-Eye Tracking and Open-Circuit Voltage

Tang,

Shi,

et al. 2023

Anal. Chem.

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Based on the controllable instantaneous self-assembly ability of long-chain branched DNA nanostructures and the synergistic effect between nucleic acid amplification without enzymes, a highly sensitive and highly specific self-powered biosensing platform is developed. Two-dimensional graphdiyne is prepared, modified on flexible carbon cloth, and then functionalized with gold nanoparticles. When DNA mi-tubes are applied on it, target thalassemia gene CD122 triggers a dual-catalytic hairpin assembly reaction. The generated nanoscale DNA is precisely captured by the DNA mi-tube, exposing binding sites and activating the hybridization chain reaction to form long-chain branched DNA. Double-stranded DNA, along with dendritic DNA carrying a large number of guanine bases, precisely captures the signal molecule methylene blue (MB), generating a significant electrochemical signal. The redox reaction of MB also causes a proportional change in the system's color, achieving a colorimetric detection functionality. An efficient dual-mode self-powered sensing platform, therefore, is established for detecting the thalassemia gene CD122. The linear response range of target concentration to open-circuit voltage and RGB Blue value is 0.0001−10,000 pM. The detection limit under electrochemical mode is 36.3 aM (S/N = 3), and under colorimetric mode, it is as low as 12.1 aM (S/N = 3). The new method exhibits high sensitivity, excellent selectivity, and high accuracy, providing a universal strategy for designing novel biosensing platforms that can be extended to the detection of other biomolecules.

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Self-powered dual-mode sensing strategy based on graphdiyne and DNA nanoring for sensitive detection of tumor biomarker

Cited by 27 publications

References 54 publications

Functional Graphdiyne for Emerging Applications: Recent Advances and Future Challenges

Functional Graphdiyne for Emerging Applications: Recent Advances and Future Challenges

“Two-in-One” PtPdCu Trimetallic Multifunctional Nanoparticles-Mediated Dual-Signal-Integrated Aptasensor for Ultradetection of Enrofloxacin

Flexible Self-Powered Sensing System Based on Novel DNA Circuit Strategy and Graphdiyne for Thalassemia Gene by Rapid Naked-Eye Tracking and Open-Circuit Voltage

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