Self-Oscillating Gel as Novel Biomimetic Materials

Yoshida, Ryo

doi:10.5772/14428

Cited by 4 publications

(6 citation statements)

References 7 publications

(10 reference statements)

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“…The synthesized gel was immersed in a BZ aqueous solution (4 mL) composed of 0.084 M NaBrO 3 , 0.0625 M malonic acid, and 0.894 M nitric acid. ,,− The experiments were carried out in a thermostat water bath at 291 ± 0.1 K. ,, A piece of the gel (3 mm × 1 mm × 1 mm) was placed on the flat bottom of the glass reactor and directly compressed with an acrylic plate (Acrylite, Mitsubishi Rayon, surface area: 7 mm × 20 mm) connected to a stepping motor (COMS Co. Ltd., PM80B-200K, Japan, minimum migration length: 14 μm) as a forced oscillator, as shown in Figure b. The external force was expressed as the relative change in the gel thickness, Δh / h 0 ( h 0 , initial thickness of the gel (∼1 mm); Δh , change in the thickness, which was equal to the compression length).…”

Section: Methodsmentioning

confidence: 99%

“…A self-oscillating polymer gel composed of N -isopropylacrylamide (NIPAAm) and [Ru(bpy) 2 (4-vinyl-4′-methylbpy)] 2+ (Ru(bpy) 2 (vmbpy)) catalyst has been reported as a novel autonomous actuator. − This gel was shown to exhibit periodic alternation between swelling and deswelling in synchronization with the oxidation and reduction of the Ru catalyst in the Belousov–Zhabotinsky (BZ) reaction. Although many kinds of self-oscillating gels have been synthesized and several interesting systems (e.g., mass transfer and robots − ) have been reported, feedback from gel oscillation to the BZ reaction has not yet been clarified experimentally.…”

Section: Introductionmentioning

confidence: 99%

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Oscillation of a Polymer Gel Entrained with a Periodic Force

2013

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The oscillation of a polymer gel induced by the Belousov-Zhabotinsky (BZ) reaction was investigated under an external force composed of a square wave. The oscillation of the BZ reaction entrained to the periodic force and the features of this entrainment changed depending on the period and duty cycle of the square wave. The experimental results suggest that the change in the volume of the gel also gave feedback to the BZ reaction. The mechanism of entrainment is discussed in relation to the compression of the gel and the reaction-diffusion system in the BZ reaction.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oscillation of a Polymer Gel Entrained with a Periodic Force

2013

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“…In this experiment, oscillation of the gel was maintained for at least 5 h. The experiments were performed in a thermostat water bath (Yamato Scientific, CLH300, Japan) at 18.0 ± 0.5 °C. 15,18,19,21 The oscillations of the gels were monitored with a digital camera (Canon, EOS kiss Digital N, Japan; time interval: 10 s) from below the water bath (see Figure 1).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Synchronization of Two Self-Oscillating Gels Based on Chemo-Mechanical Coupling

et al. 2016

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Two coupled polymer gels, showing volume oscillation caused by the Belousov-Zhabotinsky (BZ) reaction, were investigated to understand the system composed of mechanically coupled chemical oscillators. The two gels were connected with a movable plastic sheet in between and placed under constant compression. Synchronization between two identical gels occurred in a range of compression ratios. The phase difference between the two oscillating gels was not zero; instead, they showed alternate swelling-deswelling oscillations. Similar phenomena were also observed with gels of different sizes and natural oscillation periods. The experimental results suggest that a physical change in one gel can lead to a chemical change in the other and vice versa. These results were qualitatively reproduced by a mathematical model based on coupled chemical oscillators.

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“…Yoshida has studied a family of structures that can self‐oscillate, allowing drug release to synchronize with cell cycles or biorhythms 116. These gels may be designed to respond to environmental variables that include temperature, pH, and electric current 117–120.…”

Section: Implantable Mems‐based Drug Delivery Systems: Control Of Relmentioning

confidence: 99%

Microchips and controlled‐release drug reservoirs

Staples¹

2010

WIREs Nanomed Nanobiotechnol

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This review summarizes and updates the development of implantable microchip-containing devices that control dosing from drug reservoirs integrated with the devices. As the expense and risk of new drug development continues to increase, technologies that make the best use of existing therapeutics may add significant value. Trends of future medical care that may require advanced drug delivery systems include individualized therapy and the capability to automate drug delivery. Implantable drug delivery devices that promise to address these anticipated needs have been constructed in a variety of ways using micro- and nanoelectromechanical systems (MEMS or NEMS)-based technology. These devices expand treatment options for addressing unmet medical needs related to dosing. Within the last few years, advances in several technologies (MEMS or NEMS fabrication, materials science, polymer chemistry, and data management) have converged to enable the construction of miniaturized implantable devices for controlled delivery of therapeutic agents from one or more reservoirs. Suboptimal performance of conventional dosing methods in terms of safety, efficacy, pain, or convenience can be improved with advanced delivery devices. Microchip-based implantable drug delivery devices allow localized delivery by direct placement of the device at the treatment site, delivery on demand (emergency administration, pulsatile, or adjustable continuous dosing), programmable dosing cycles, automated delivery of multiple drugs, and dosing in response to physiological and diagnostic feedback. In addition, innovative drug-medical device combinations may protect labile active ingredients within hermetically sealed reservoirs.

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Self-Oscillating Gel as Novel Biomimetic Materials

Cited by 4 publications

References 7 publications

Oscillation of a Polymer Gel Entrained with a Periodic Force

Oscillation of a Polymer Gel Entrained with a Periodic Force

Synchronization of Two Self-Oscillating Gels Based on Chemo-Mechanical Coupling

Microchips and controlled‐release drug reservoirs

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