Self-Organized Intracellular Ultradian Rhythms Provide Direct Cell-Cell Communication

Brodsky, V. Ya.; Lloyd, David

doi:10.1007/978-1-4020-8352-5_3

Cited by 9 publications

(5 citation statements)

References 91 publications

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“…There is some consensus in the literature on the adaptive value of EUEs, at least for the EUEs of activity and other behaviors [110]. Like other biological rhythms, the functional significance of EUEs might be in optimizing biological activities [111] by synchronizing compatible processes, and preventing the simultaneous activation of incompatible processes [10];preparing biological systems to respond to stimuli such as cell–cell communication [112], and the maintenance of neuronal integrity and alertness [113];interacting with circadian rhythms.…”

Section: The Role Of Euesmentioning

confidence: 99%

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Episodic Ultradian Events—Ultradian Rhythms

Goh

Maloney

Mark

et al. 2019

Biology

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In the fast lane of chronobiology, ultradian events are short-term rhythms that have been observed since the beginning of modern biology and were quantified about a century ago. They are ubiquitous in all biological systems and found in all organisms, from unicellular organisms to mammals, and from single cells to complex biological functions in multicellular animals. Since these events are aperiodic and last for a few minutes to a few hours, they are better classified as episodic ultradian events (EUEs). Their origin is unclear. However, they could have a molecular basis and could be controlled by hormonal inputs—in vertebrates, they originate from the activity of the central nervous system. EUEs are receiving increasing attention but their aperiodic nature requires specific sampling and analytic tools. While longer scale rhythms are adaptations to predictable changes in the environment, in theory, EUEs could contribute to adaptation by preparing organisms and biological functions for unpredictability.

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Section: The Role Of Euesmentioning

confidence: 99%

“…preparing biological systems to respond to stimuli such as cell–cell communication [112], and the maintenance of neuronal integrity and alertness [113];…”

Section: The Role Of Euesmentioning

confidence: 99%

Episodic Ultradian Events—Ultradian Rhythms

Goh

Maloney

Mark

et al. 2019

Biology

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“…Rhythmic development occurs at multiple timescales, including within-a-day (ultradian rhythms; URs; Bourguignon, 1988 ), daily (circadian rhythms; CRs; MacKinnon et al, 1978 ; Garcia et al, 2001 ), and multi-day ovulatory cycles in females (ovulatory rhythms; ORs; Vidal, 2017 ). These rhythms occur across physiological systems, serving to increase the efficiency of signal transduction ( Lloyd and Stupfel, 1991 ; Brodsky and Lloyd, 2008 ; Walker et al, 2010 ), temporally segregate incompatible processes ( Panda, 2016 ), synchronize internal systems to the environment ( Dibner et al, 2010 ), and maximize reproductive success ( Carlson and Shaw, 2019 ). Although structure at one timescale can be modulated by changes at another ( Backstrom et al, 1982 ; Shechter and Boivin, 2010 ), distinct mechanisms underlie each rhythmic frequency.…”

Section: Introductionmentioning

confidence: 99%

Adolescent Development of Biological Rhythms in Female Rats: Estradiol Dependence and Effects of Combined Contraceptives

2021

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Adolescence is a period of continuous development, including the maturation of endogenous rhythms across systems and timescales. Although, these dynamic changes are well-recognized, their continuous structure and hormonal dependence have not been systematically characterized. Given the well-established link between core body temperature (CBT) and reproductive hormones in adults, we hypothesized that high-resolution CBT can be applied to passively monitor pubertal development and disruption with high fidelity. To examine this possibility, we used signal processing to investigate the trajectory of CBT rhythms at the within-day (ultradian), daily (circadian), and ovulatory timescales, their dependence on estradiol (E2), and the effects of hormonal contraceptives. Puberty onset was marked by a rise in fecal estradiol (fE2), followed by an elevation in CBT and circadian power. This time period marked the commencement of 4-day rhythmicity in fE2, CBT, and ultradian power marking the onset of the estrous cycle. The rise in circadian amplitude was accelerated by E2 treatment, indicating a role for this hormone in rhythmic development. Contraceptive administration in later adolescence reduced CBT and circadian power and resulted in disruption to 4-day cycles that persisted after discontinuation. Our data reveal with precise temporal resolution how biological rhythms change across adolescence and demonstrate a role for E2 in the emergence and preservation of multiscale rhythmicity. These findings also demonstrate how hormones delivered exogenously in a non-rhythmic pattern can disrupt rhythmic development. These data lay the groundwork for a future in which temperature metrics provide an inexpensive, convenient method for monitoring pubertal maturation and support the development of hormone therapies that better mimic and support human chronobiology.

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“…The organization of the rhythm protein synthesis may be of significance because of the ubiquitous occurrence of melatonin – from plants, bacteria and protists to all mammalian tissues. Being one of the prime signal systems of protein metabolism and organization of cell populations, melatonin, as well as its precursor serotonin, along with noradrenalin and dopamine, is conserved in a wide range of organisms and may be an important factor in multicellular evolution (see also Brodsky and Lloyd, 2008). The fractal nature of the rhythm of protein synthesis along with other ultradian oscillations with a set of functionally dependent periods may underlie tissue adaptations as an expression of the coordinated activity of cell populations (Lloyd and Rossi, 1992; Brodsky, 2006).…”

Section: Discussionmentioning

confidence: 99%

Melatonin as the most effective organizer of the rhythm of protein synthesis in hepatocytes in vitro and in vivo

Brodsky

Zvezdina

2010

Cell Biology International

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Recent data has extended a large array of melatonin functions by the discovery of melatonin's involvement in the organization and regulation of the rhythm of intracellular protein synthesis. An ultradian rhythm in total protein synthesis has been detected in primary hepatocyte cultures 5 min after addition of 1-5 nM melatonin to the medium. The melatonin effect was mediated via its receptors (as shown in experiments with luzindole), leading to the cell synchronization as well as the mean rate of protein synthesis rate being increased. The chain of processes synchronizing the oscillation of the rate protein synthesis throughout the hepatocyte population includes Ca²+ fluxes {experiments with BAPTA-AM [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (acetomethyl ester)]}. Inhibition of protein kinase activity (experiments with H7) inhibited the synchronizing function of melatonin. Activation of protein kinase activity results in a shift of the protein synthesis oscillation; the effect was the same as melatonin added to the culture medium. In another series of experiments, after melatonin was intraperitoneally injected to rat (0.015-0.020 μg/kg), hepatocytes were isolated and cultures established. A synchronizing effect of melatonin in vivo was detected as early as in the estimates from the direct action of melatonin on cell cultures. In the cultures obtained from old rats provided with melatonin, the amplitude of protein synthesis rhythm was enhanced, i.e. cell-cell interactions were increased, as well as rate of the protein synthesis being enhanced.

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Self-Organized Intracellular Ultradian Rhythms Provide Direct Cell-Cell Communication

Cited by 9 publications

References 91 publications

Episodic Ultradian Events—Ultradian Rhythms

Episodic Ultradian Events—Ultradian Rhythms

Adolescent Development of Biological Rhythms in Female Rats: Estradiol Dependence and Effects of Combined Contraceptives

Melatonin as the most effective organizer of the rhythm of protein synthesis in hepatocytes in vitro and in vivo

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