“…Since the discovery of graphene in 2004, two-dimensional (2D) layered materials have received great attention due to their unique mechanical, thermal, optical, and electrical properties. − Nowadays, 2D materials (e.g., graphene − and transition metal dichalcogenides) have been considered as promising candidates for next-generation SERS platforms due to their atomic uniformity, biological compatibility, seamless structure, atomic thickness, and chemical inertness. Studies have shown that CM plays a major role in the SERS of 2D materials and the fluorescence background of molecules can be effectively quenched by 2D materials. ,, However, the enhancement factor and limit of detection of 2D substrates are still not high enough, e.g., detection limit of MoS 2 is above 10 –7 M. To increase the enhancement factor of SERS for 2D materials, various defect engineering schemes are developed.…”