Self‐Organization of an <scp>L</scp>‐Ether‐amide Phospholipid in Large Two‐Dimensional Chiral Crystals

Zhai, Xiuhong; He, Qiang; Li, Junbai; Brezesinski, Gerald; Möhwald, Helmuth

doi:10.1002/cphc.200300912

Cited by 8 publications

(5 citation statements)

References 34 publications

(13 reference statements)

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“…As oen seen in simple chiral lipids, [8][9][10][11][12][13][14] ordered domains growing in a disordered uid monolayer of dynePE are chiral in shape over a wide temperature range, between 30 and 37 C. Unlike in these previous studies, we found that the domains of the ordered dynePE grow in at least four hierarchical levels at different length scales. The overall pattern looks like stripes inside circular domains, where the stripes may be arranged either concentrically or in a spiral structure, depending on the temperature.…”

Section: A Introductioncontrasting

confidence: 55%

Chiral hierarchical self-assembly in Langmuir monolayers of diacetylenic lipids

et al. 2013

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When compressed in the intermediate temperature range below the chain-melting transition yet in the low-pressure liquid phase, Langmuir monolayers made of chiral lipid molecules form hierarchical structures. Using Brewster angle microscopy to reveal this structure, we found that as the liquid monolayer is compressed, an optically anisotropic condensed phase nucleates in the form of long, thin claws. These claws pack closely to form stripes. This appears to be a new mechanism for forming stripes in Langmuir monolayers. In the lower temperature range, these stripes arrange into spirals within overall circular domains, while near the chain-melting transition, the stripes arrange into target patterns.We attributed this transition to a change in boundary conditions at the core of the largest-scale circular domains.

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Section: A Introductioncontrasting

confidence: 55%

Chiral hierarchical self-assembly in Langmuir monolayers of diacetylenic lipids

et al. 2013

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“…The compression leads to a dramatic increase of the domain size, and the number of domains is almost unchanged. If the domains grow to a certain size they come together and start to fuse in the condensed-phase region . Chiral domains formed at the air/water interface must have a long-range molecular orientational order.…”

Section: Resultsmentioning

confidence: 99%

“…During the growth of the chiral domains, they coalesce and fuse to form huge domains. The largest chiral domains are observed with a diameter of approximately 400 μm …”

Section: Resultsmentioning

confidence: 99%

“…If the domains grow to a certain size they come together and start to fuse in the condensed-phase region. 33 Chiral domains formed at the air/water interface must have a longrange molecular orientational order. This orientation must play a key role in forming the chiral structure and hence induces the domain growth up to 300 µm, which was rarely observed for phospholipids before.…”

Section: Resultsmentioning

confidence: 99%

“…The largest chiral domains are observed with a diameter of approximately 400 µm. 33 However, the continuous increase of temperature does not lead to further growth of the chiral domains. The domains possess a similar spiral structure at 30 °C but with a smaller size (Figure 4e).…”

Section: Resultsmentioning

confidence: 99%

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Thermodynamics and Structures of Amide Phospholipid Monolayers

et al. 2004

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Monolayers of newly synthesized amide phospholipids, 1-O-hexadecyl-2-N-palmitoyl-2-amino-2-deoxy-snglycero-3-phosphocholine (L-ether-amide-PC) and 1-palmitoyl-2-N-palmitoyl-2-amino-2-deoxy-sn-glycero-3-phosphocholine (L-ester-amide-PC) were investigated at the air/subphase interface by Brewster angle microscopy combined with a conventional LB trough and Grazing incidence X-ray diffraction (GIXD). Both systems investigated exhibit two-dimensional domains with characteristic shape in the coexistence region between liquid-expanded (LE) and liquid-condensed (LC) phases. Especially L-ether-amide-PC shows highly chiral domains depending on temperature. The largest chiral domains (400 µm) growing in a clockwise direction are obtained at 25 °C. Such large domains have rarely been observed for phospholipids before. Thermodynamic data derived from π-A isotherms provide information about critical temperature (T c ) and phase transition enthalpy (∆H) for both amide phospholipids. The amide group leads to pronounced differences in the thermodynamic parameters compared with DPPC. The two-dimensional structures of the monolayers were investigated by GIXD. The results show that both amide phospholipids exhibit chiral in-plane structures. In the case of L-ether-amide-PC, the tilt angle of the aliphatic chains decreases only slightly with increasing pressure. On the contrary, the tilt angle of the aliphatic chains of L-ester-amide-PC shows strong dependence on surface pressure similar to DPPC. Possible hydrogen bonds involving the amide group seem to enhance the chiral interaction and play therefore a key role in the formation of extremely large chiral domains. The affects of substitution in the sn-1 position on structure formation are discussed in detail.

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Biomimetic Membranes

2010

Molecular Assembly of Biomimetic Systems

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Effect of protein penetration into phospholipid monolayers: morphology and structure . Colloids Surf. A , 168 , 287 -296 . 40 Li , J.B. , Kretzschmar , G. , Miller , R. , and M ö hwald , H. ( 1999 ) Viscoelasticity of phospholipid layers at different fl uid interfaces . Colloids Surf. A , 149 , 491 -497 . 41 Li , J.B. , Miller , R. , and M ö hwald , H. ( 1996 ) Phospholipid monolayers and their dynamic interfacial behaviour studied by axisymmetric drop shape analysis . Axisymmetrical drop shape analysis as a fi lm balance . Colloids Surf. A , 88 , 51 -58 . 44 Li , J.B. , Miller , R. , Vollhardt , D. , Weidemann , G. , and M ö hwald , H. ( 1996 ) Isotherms of phospholipid monolayers measured by a pendant drop technique . Colloid Polym. Sci. , 274 , 995 -999 . 45 Li , J.B. , Miller , R. , and M ö hwald , H. ( 1996 ) Characterisation of phospholipid

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Self‐Organization of an L‐Ether‐amide Phospholipid in Large Two‐Dimensional Chiral Crystals

Cited by 8 publications

References 34 publications

Chiral hierarchical self-assembly in Langmuir monolayers of diacetylenic lipids

Chiral hierarchical self-assembly in Langmuir monolayers of diacetylenic lipids

Thermodynamics and Structures of Amide Phospholipid Monolayers

Biomimetic Membranes

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