Self-mutilation of the penis in C57BL/6N mice

Hong, Chou C.; Ediger, Raymond D.

doi:10.1258/002367778780953116

Cited by 20 publications

(7 citation statements)

References 1 publication

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Others have reported a high incidence of obstructive genito-urinary disease in male mice housed singly, suggesting that fight-related trauma may not be the sole factor in all cases of MUS (Everitt et a/., 1988). Self-mutilation of the penis in rodents has been associated with urethral plugs, distension of the urinary bladder, and intense inflammation of the pelvic tissues (Hong & Ediger, 1978). Clinical signs of penile prolapse and preputial skin sores in our case are consistent with a trauma-related pathogenesis.…”

Section: Wojcinski Et Afsupporting

confidence: 70%

Struvite urolithiasis in a B6C3F1 mouse

Wojcinski¹,

Renlund

Barsoum

et al. 1992

Lab Anim

View full text Add to dashboard Cite

SummaryIn a 2 year carcinogenicity bioassay using B6C3Fl mice, one male mouse developed clinical signs near termination of the study, comprising skin sores around the prepuce, penile prolapse and urine scalding. The predominant finding at necropsy was a markedly distended urinary bladder filled with numerous crystallized particles. Microscopically, there was subacute cystitis with marked hyperplasia of the transitional epithelium. X-ray diffraction analysis of the crystals showed a diffraction pattern characteristic of struvite (ammonium magnesium phosphate). The implications of the spontaneous occurrence of bladder stones in rodents on long-term toxicology studies are discussed.

show abstract

Section: Wojcinski Et Afsupporting

confidence: 70%

Struvite urolithiasis in a B6C3F1 mouse

Wojcinski¹,

Renlund

Barsoum

et al. 1992

Lab Anim

View full text Add to dashboard Cite

show abstract

“…It is well known that Pasteurella pneumotro pica is distributed in several species of animals such as mouse, rat, hamster, guinea pig and dog [1,10,11], sometimes causing pneumonia [1][2][3]9, 10], subcutaneous abscess [11,15,16,18], mastitis [8,15] In the case of rats, P. pneumotro pica was isolated from all individuals examined, regardless of their ages, as shown in Table 2. The pharyngolarynx was also the prominent site harboring the organisms like in mice, showing 100% isolation rate in all age groups of rats.…”

Section: * Toxicologicalmentioning

confidence: 99%

Carrier State of <I>Pasteurella pneumotropica</I> in Mice and Rats

Saito

Kohjima

Sano

et al. 1981

Experimental Animals

View full text Add to dashboard Cite

Localizationof Pasteurella pneumotro pica was investigated in the respiratory tract, conjunctiva and vagina of 5-week-old, 10-week-old and retired asymptomatic mice and rats.The highest isolation rate of the organisms was obtained in the pharyngolarynx, showing 85 to 97.5% in carrier mice and 100% in carrier rats. Numbers of the organisms in this site were 103-5 and 107-8 organisms/g tissue in 4-week-old mice and rats, respectively. Isolation rates in the nasal cavity and trachea of the both animals were not so high as those in the pharyngolarynx, but usually higher than those in the external nares.The organisms were rarely isolated from the lung.Isolation of the organisms from the conjunctiva was common in rats, especially in young ones, but rare in mice. About 30% of carrier mice and 50 to 100% of carrier rats harbored the organisms in their vaginas.

show abstract

“…In a breeding population of WT C57BL/6N mice, 8.5% of males generated a urethral plug in the distal urethra resulting in bladder distension and irritation that increased rates of penile mutilation [44]. Additionally, the diabetic model KK-A y is reported to have approximately 75% penetrance of urethral plugs leading to obstructive kidney failure, representing the largest contributor to spontaneous death observed in these animals [41].…”

Section: Discussionmentioning

confidence: 99%

Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome

et al. 2016

View full text Add to dashboard Cite

Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by loss of acquired skills during development, autonomic dysfunction, and an increased risk for premature lethality. Clinical experience identified a subset of individuals with RTT that present with urological dysfunction including individuals with frequent urinary tract infections, kidney stones, and urine retention requiring frequent catheterization for bladder voiding. To determine if urologic dysfunction is a feature of RTT, we queried the Rett Syndrome Natural History Study, a repository of clinical data from over 1000 individuals with RTT and found multiple instances of urological dysfunction. We then evaluated urological function in a mouse model of RTT and found an abnormal pattern of micturition. Both male and female mice possessing Mecp2 mutations show a decrease in urine output per micturition event. Furthermore, we identified signs of kidney failure secondary to urethral obstruction. Although genetic strain background significantly affects both survival and penetrance of the urethral obstruction phenotype, survival and penetrance of urethral obstruction do not directly correlate. We have identified an additional phenotype caused by loss of MeCP2, urological dysfunction. Furthermore, we urge caution in the interpretation of survival data as an endpoint in preclinical studies, especially where causes of mortality are poorly characterized.

show abstract

Self-mutilation of the penis in C57BL/6N mice

Cited by 20 publications

References 1 publication

Struvite urolithiasis in a B6C3F1 mouse

Struvite urolithiasis in a B6C3F1 mouse

Carrier State of <I>Pasteurella pneumotropica</I> in Mice and Rats

Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome

Contact Info

Product

Resources

About