Self‐mutilation in chorea–acanthocytosis: Manifestation of movement disorder or psychopathology?

Novel VPS13A Gene Mutations Identified in Patients Diagnosed with Chorea-acanthocytosis (ChAc): Case Presentation and Literature Review

“…As a matter of fact, perioral chorea, bruxism and self-mutilation behaviors, demonstrated by the two patients, are all concrete manifestations of the hyperkinetic movements (see Tables 1 , 2 ). In particular, several previous reports have already indicated that self-mutilation, especially tongue and lip biting, were critically suggestive of ChAc (Walker et al, 2006, 2007; Gooneratne et al, 2014) (see Tables 1 , 2 ). What is interesting is that the self-mutilation behaviors can be considerably alleviated by holding a roll of cloth in mouth just as performed by patient 2.…”

Self-Injurious Behaviour in SCA17: A New Clinical Observation

“…26 However, some studies have proved that skin picking disorder, despite resembling the compulsive rituals of obsessive compulsive disorder, has different underlying mechanisms. 27,28 …”

Quetiapine Treatment for Self-Mutilation in Chorea-Acanthocytosis

“…1 Limb and orobuccal chorea as well as frequent lip and tongue mutilation are also seen in neuroacanthocytosis. 2 In this report, successful treatment with quetiapine in a case of choreaacanthocytosis (a subtype of neuroacanthocytosis) with prominent self-mutilating orobuccal and finger-biting behavior is presented.…”

“…8 A previous report concerning a choreaacanthocytosis case has proposed that selfmutilation symptoms are a form of motor compulsion and can be viewed as obsessivecompulsive-type behavioral disorder. 2 Some researchers have discussed that the use of serotonin reuptake inhibitors may provide beneficial results in patients with chorea-acanthocytosis, although in some reports, the use of a serotonin reuptake inhibitor did not provide a favorable outcome. 9,10 Thus, the possible benefit of paroxetine use should also be discussed in relation to the improvement observed in our case.…”