Self-motion evokes precise spike timing in the primate vestibular system

Jamali, Mohsen; Chacron, Maurice J.; Cullen, Kathleen E.

doi:10.1038/ncomms13229

Cited by 36 publications

(57 citation statements)

References 68 publications

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“…; Jamali et al . ). Indeed, the gain–decrease paradigm did not result in persistent changes in SS activity, but only in changes in CS activity that may influence plasticity in the vestibular and cerebellar nuclei (Pugh & Raman, ; De Zeeuw et al .…”

Section: Discussionmentioning

confidence: 97%

Mechanisms underlying vestibulo‐cerebellar motor learning in mice depend on movement direction

Voges

Post

et al. 2017

The Journal of Physiology

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Key points Directionality, inherent to movements, has behavioural and neuronal correlates.Direction of vestibular stimulation determines motor learning efficiency.Vestibulo‐ocular reflex gain–increase correlates with Purkinje cell simple spike potentiation.The locus of neural correlates for vestibulo‐ocular reflex adaptation is paradigm specific. AbstractCompensatory eye movements elicited by head rotation, also known as vestibulo‐ocular reflex (VOR), can be adapted with the use of visual feedback. The cerebellum is essential for this type of movement adaptation, although its neuronal correlates remain to be clarified. In the present study, we show that the direction of vestibular input determines the magnitude of eye movement adaptation induced by mismatched visual input in mice, with larger changes during contraversive head rotation. Moreover, the location of the neural correlate of this changed behaviour depends on the type of paradigm. Gain–increase paradigms induce increased simple spike (SS) activity in ipsilateral cerebellar Purkinje cells (PC), which is in line with eye movements triggered by optogenetic PC activation. By contrast, gain–decrease paradigms do not induce changes in SS activity, indicating that the murine vestibulo‐cerebellar cortical circuitry is optimally designed to enhance ipsiversive eye movements.

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Section: Discussionmentioning

confidence: 97%

Mechanisms underlying vestibulo‐cerebellar motor learning in mice depend on movement direction

Voges

Post

et al. 2017

The Journal of Physiology

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“…Besides firing rates, the temporal pattern of spike timings also carries important information about brain functions. For instance, it has been shown that temporal patterns encode the information of auditory (Machens et al, 2001;Narayan et al, 2006;Wang et al, 2007;Fukushima et al, 2015;Krause et al, 2017), gustatory (Di Lorenzo and Victor, 2003), motor (Vargas-Irwin et al, 2015), olfactory (MacLeod et al, 1998), somatosensory (Harvey et al, 2013), vestibular (Jamali et al, 2016), and visual (Mechler et al, 1998;Victor and Purpura, 1998;Reich et al, 2001;Carrillo-Reid et al, 2015) systems, as well as behavioral adaptation (Logiaco et al, 2015) and sleep (Tabuchi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Finally, by removing rate dependence from the SPIKEdistance, Satuvuori et al (2017) proposed the RI-SPIKE-distance as a distance purely sensitive to timing. The spike train distances developed so far have been used in a number of studies for the analysis of neural firing patterns (MacLeod et al, 1998;Mechler et al, 1998;Victor and Purpura, 1998;Machens et al, 2001;Reich et al, 2001; Di Lorenzo and Victor, 2003;Narayan et al, 2006;Wang et al, 2007;Harvey et al, 2013;Fukushima et al, 2015;Logiaco et al, 2015;Vargas-Irwin et al, 2015;Jamali et al, 2016;Krause et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

A Spike Train Distance Robust to Firing Rate Changes Based on the Earth Mover’s Distance

Sihn

Kim

2019

Front. Comput. Neurosci.

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Neural spike train analysis methods are mainly used for understanding the temporal aspects of neural information processing. One approach is to measure the dissimilarity between the spike trains of a pair of neurons, often referred to as the spike train distance. The spike train distance has been often used to classify neuronal units with similar temporal patterns. Several methods to compute spike train distance have been developed so far. Intuitively, a desirable distance should be the shortest length between two objects. The Earth Mover's Distance (EMD) can compute spike train distance by measuring the shortest length between two spike trains via shifting a fraction of spikes from one spike train to another. The EMD could accurately measure spike timing differences, temporal similarity, and spikes time synchrony. It is also robust to firing rate changes. Victor and Purpura (1996) distance measures the minimum cost between two spike trains. Although it also measures the shortest path between spike trains, its output can vary with the timescale parameter. In contrast, the EMD measures distance in a unique way by calculating the genuine shortest length between spike trains. The EMD also outperforms other existing spike train distance methods in measuring various aspects of the temporal characteristics of spike trains and in robustness to firing rate changes. The EMD can effectively measure the shortest length between spike trains without being considerably affected by the overall firing rate difference between them. Hence, it is suitable for pure temporal coding exclusively, which is a predominant premise underlying the present study.

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“…Although these findings do not distinguish adequate stimuli for activation of these networks, they do indicate that independent processing streams to the periaqueductal gray, locus coeruleus, and serotonergic/non‐serotonergic raphe cells are affected by galvanic stimulation. Since these sites are also modulated during nociception, they are potential mediators of interactions between vestibular stimulation and pain perception that could alter normal coding via precise spike timing . One predicts similar results for caloric stimulation in the ear canal.…”

Section: Discussion/observationsmentioning

confidence: 81%

Vestibular Neuroscience for the Headache Specialist

Balaban

Black²,

Silberstein

2019

Headache

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Background.-The vestibular system is a multifaceted, integrative sensory system that is often referred to as the "multi-sensory" sense. There is an extensive literature about the vestibular sensory organs and afferent nerve pathways; however, this rich resource is often unknown to the headache specialist.Aims.-In this review, we highlight the significance of vestibular sensory processing beyond its role in the maintenance of balance. The role of the vestibular system in migraine pathophysiology is emphasized, not just in how it impacts dizziness or nausea, but also in its higher order effects on mood and cognition. How the vestibular system responds to current and new migraine therapies, such as anti-CGRP (calcitonin gene-related peptide) antibodies, is also discussed.Conclusions.-The vestibular system is not just about balance; this should be taken into account by clinicians as they assess their patients' associated non-headache symptoms. There is a co-occurrence of migraine and vestibular-based problems and a confluence of disciplines relevant to vestibular migraine.Abbreviations: 5-HT receptors (5-hydroxytryptamine), (serotonin receptors) class of G protein coupled receptor and ligandgated ion channels. The subscript designations refer to specific receptor types, ATPase adenosine triphosphatase, an enzyme that catalyzes the hydrolysis or decomposition of ATP (adenosine triphosphate) into ADP (adenosine diphosphate) and a free phosphate ion, BOLD fMRI blood oxygen level-dependent functional magnetic resonance imaging, Cav2.1 voltage-dependent calcium channel, c-FOS protein that is often used as an indirect marker of neuronal activity, ICHD-3 International Classification of Headache Disorders, NaKA sodiumpotassium ATPase, SSRI selective serotonin reuptake inhibitor, Substance P neuropeptide that may affect vasodilation, inflammation, pain expression, and other regulated processes, TRPV1 transient receptor potential cation channel subfamily V, member 1, UCP2, 3 mitochondrial uncoupling protein 2 (or 3) HEADACHE CURRENTS Headache CurrentsHeadache Headache Currents mismatch") 20 can result in motion sickness, simulator sickness, and cybersickness. [21][22][23][24][25][26] Other somatic, non-vestibular signals that are involved in balance control and spatial orientation have been reviewed elsewhere 7 Since every tissue in the body has mass (including blood), linear acceleration (including gravity) alters sensory signals from baroreceptors, visceral pressure receptors, and somatic proprioceptors. These multiple sensory inputs simultaneously coordinate motor and autonomic responses during movement and changes in posture, particularly during unusual conditions (eg, swimming underwater). Vestibular Sensory PeripheryBody and head movements produce inertial and gravitational forces that are detected by vestibular sensory organs. 27 Since these organs are embedded in the temporal bone of the skull, the sensory information is "head-referenced." These organs are similar in structure in all vertebrates with jaws. 28 There are...

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Self-motion evokes precise spike timing in the primate vestibular system

Cited by 36 publications

References 68 publications

Mechanisms underlying vestibulo‐cerebellar motor learning in mice depend on movement direction

Mechanisms underlying vestibulo‐cerebellar motor learning in mice depend on movement direction

A Spike Train Distance Robust to Firing Rate Changes Based on the Earth Mover’s Distance

Vestibular Neuroscience for the Headache Specialist

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