Self-mineralizing Ca-enriched methacrylated gellan gum beads for bone tissue engineering

Vieira, Sheylla Nayara Sales; Morais, Alain da Silva; Garet, Elina; Silva‐Correia, Joana; Reis, Rui L.; González-Fernández, África; Oliveira, Joaquím M.

doi:10.1016/j.actbio.2019.01.053

Cited by 57 publications

(36 citation statements)

References 60 publications

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“…42 Some studies have shown that Ca-GG hydrogels are functional bone-bioactive materials that are not only able to mineralize but also compatible with efficient drug delivery applications in a wide range of molecular weights. 18,43 Previous study showed that proper delivery of IL-4 can generate the most preferable M1/M2 macrophage profile, resulting in a pro-healing microenvironment coupled with enhanced downstream osteogenesis. 27 Therefore, we developed a strategy that using Ca-GG hydrogel bead to delivers IL-4 for repair of jaw defect.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Ca-GG hydrogel beads are compatible with a wide range of molecular drug delivery applications. 18 Macrophages are myeloid precursor cells that derived from bone marrow and are an important part of the body's innate immune system. Macrophages play an important role in inflammation, host defence, tissue repair and metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…A previous study showed that Ca‐GG hydrogels exhibited strong mineralization capacity because the incorporated calcium ions facilitate phosphate ion deposition and further mineralization. Furthermore, Ca‐GG hydrogel beads are compatible with a wide range of molecular drug delivery applications 18 …”

Section: Introductionmentioning

confidence: 99%

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Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

et al. 2020

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“…Due to the superior osteogenic effect of Ti, a 5%Tiβ-TCP composite scaffold exhibited the highest capacity to enhance bone formation, as compared to 5% Zn-β-TCP, 5% Mgβ-TCP, and β-TCP alone. 93 Vieira et al 94 synthesized selfmineralizing, calcium-enriched methacrylated gellan gum (GG-MA) hydrogel beads, which, when placed in simulated body fluid, were spontaneously covered with a white mineral layer exhibiting the typical cauliflower-like morphology of HA. The thickness of the mineralized HA layer increased over 8 weeks in vitro.…”

Section: Applications Of Smart Biomaterials Responding To Internal Mamentioning

confidence: 99%

“…When implanted subcutaneously in CD1 male mice for up to 8 weeks, the beads were completely calcified without any signs of an inflammatory reaction. 94 As a potential molecule for promoting bone regeneration, specifically for enhancing muscle-bone connectivity, Irisin, a skeletal muscle-derived cytokine, loaded into silk/calcium silicate/sodium alginate composite hydrogels, upregulated the expression of several osteogenic markers containing RUNX2, ALP, BMP2, Osterix, OCN, and OPN in cultured BMSCs and improved the repair of calvarial defects in a rat model in vivo. 95 Sinapic acid is a plantderived phenolic compound with potentially beneficial effects for bone regeneration.…”

Section: Applications Of Smart Biomaterials Responding To Internal Mamentioning

confidence: 99%

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

et al. 2021

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The demand for biomaterials that promote the repair, replacement, or restoration of hard and soft tissues continues to grow as the population ages. Traditionally, smart biomaterials have been thought as those that respond to stimuli. However, the continuous evolution of the field warrants a fresh look at the concept of smartness of biomaterials. This review presents a redefinition of the term “Smart Biomaterial” and discusses recent advances in and applications of smart biomaterials for hard tissue restoration and regeneration. To clarify the use of the term “smart biomaterials”, we propose four degrees of smartness according to the level of interaction of the biomaterials with the bio-environment and the biological/cellular responses they elicit, defining these materials as inert, active, responsive, and autonomous. Then, we present an up-to-date survey of applications of smart biomaterials for hard tissues, based on the materials’ responses (external and internal stimuli) and their use as immune-modulatory biomaterials. Finally, we discuss the limitations and obstacles to the translation from basic research (bench) to clinical utilization that is required for the development of clinically relevant applications of these technologies.

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Advances in Photocrosslinkable Materials for 3D Bioprinting

Zhang

Yan

2021

Adv Eng Mater

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3D bioprinting integrating multidisciplinary advances in engineering, cell biology, and material science is able to fabricate artificial tissues and organ‐like structures with biology or clinic‐relevant size, shape, and structural integrity. Therefore, 3D bioprinting has huge potential in tissue engineering and regenerative medicine. Suitable bioink plays a key role in the modulation of the printing process, the properties, and functions of printed constructs. Herein, the advances in photocrosslinkable biomaterials are focused on, which have been proven as promising types of bioinks for 3D bioprinting. The general strategies of 3D bioprinting and the main mechanisms involved in photocrosslinking are first discussed. Then, the recent advances in photocrosslinkable bioinks including natural protein‐ and polysaccharide‐based materials, synthetic polymers, and decellularized extracellular matrix (dECM)‐based materials are highlighted. Finally, the ongoing challenges in the delicate balance between the printability and biological activities of photocrosslinkable biomaterials are discussed and the outlook for this emerging area is analyzed.

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Self-mineralizing Ca-enriched methacrylated gellan gum beads for bone tissue engineering

Cited by 57 publications

References 60 publications

Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

Interleukin‐4‐loaded hydrogel scaffold regulates macrophages polarization to promote bone mesenchymal stem cells osteogenic differentiation via TGF‐β1/Smad pathway for repair of bone defect

On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook

Advances in Photocrosslinkable Materials for 3D Bioprinting

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