Self-microemulsifying drug delivery system as carrier for the oral delivery of glimepiride: Formulation development, optimization, in-vitro characterization, stability assessment, ex-vivo permeation, and in-vivo antidiabetic activity in albino mice
Srinivas Bhairy,
Shruti Mane,
Sameer Padhye
Abstract:Aim: The research aimed to design the glimepiride self-micro emulsifying drug delivery system (SMEDDS) for increased oral bioavailability in albino mice by assessing hypoglycemic efficacy.
Materials and Methods: The optimized liquid SMEDDS (L-SMEDDS) prepared by emulsification of Capryol® 90 (oil), Kolliphore® EL (surfactant), and Transcutol® P (co-surfactant) were screened based on their solubility in glimepiride. Adsorption onto Aerosil® 200 Pharma produced solid SMEDDS (S-SMEDDS), and further direct compres… Show more
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