Self-Medication with Ganoderma lucidum (“Reishi”) to Combat Parkinson's Disease Symptoms: A Single Case Study

Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative disease for which only symptomatic treatments, mainly focused on motor symptoms. In contrast, conventional pharmacological treatments do not address cognitive impairment and emotional dysfunction. Together with potential treatment side effects, these can cause distress, lower the quality of life, and increase motor impairment in patients. Preclinical research suggests that the Traditional Chinese Medicine Ganoderma lucidum (“Reishi”) can alleviate symptoms in neurological disorders like PD. However, no clinical research to date has addressed this. An (unmedicated) patient, 50 years of age and diagnosed with PD for 5 years, approached the author as he decided to initiate self-treatment with Reishi, lasting 3 months. He wanted to evaluate the effects and decide to continue self-treatment or not. He agreed to be followed during this period, using questionnaires asking him about his (non-)motor symptoms. The most notable finding was the increase in Mindfulness, 3 months after self-treatment started. The motor symptoms stayed stable, there were no extreme changes in quality of life, and emotion regulation seemed to deteriorate over time while slightly improving at the 3-month assessment. While the findings do not allow firm conclusions seen the nature ( N = 1) of this study, the small positive changes in some facets of affective behavior and the patient's experience, combined with the evidence from preclinical research, warrant clinical studies in this patient population.

Ganoderic Acid A targeting leucine‐rich repeat kinase 2 involved in Parkinson's disease–A computational study

“…Study conducted by Sana et al (2021) shows that Ganoderma lucidium has neuroprotective and anti‐parkinsonian action on male Wistar rats against rotenone induced Parkinsonian affect 18 . A single case study of self‐medication of Ganoderma lucidium in which a 50‐year‐old male showed positive effects by improving motor skills, thought process, as well as emotion regulation, strengthens the clinical research findings 19 . Thus, GAA can be used for in vitro and vivo studies, which can lead to drug development of PD.…”

“… 18 A single case study of self‐medication of Ganoderma lucidium in which a 50‐year‐old male showed positive effects by improving motor skills, thought process, as well as emotion regulation, strengthens the clinical research findings. 19 Thus, GAA can be used for in vitro and vivo studies, which can lead to drug development of PD.…”

The Biological Activity of Ganoderma lucidum on Neurodegenerative Diseases: The Interplay between Different Active Compounds and the Pathological Hallmarks

“…A single case study involving self-medication with Ganoderma lucidum to combat Parkinson’s disease symptoms showed small positive changes in some facets of affective behavior. While this does not allow for firm conclusions, it suggests that clinical studies in this patient population may be warranted [ 141 ]. A randomized, double-blind, and placebo-controlled study of GLP in neurasthenia indicated that the extract was significantly superior to placebo in the clinical improvement of symptoms [ 142 ].…”