“…Self-management-Intervention (characteristic: iterative process with ≥ 2 components*) [5,7,29,31] Exacerbation action plan embedded in self-management intervention [4,29,31] Interventions for integrated care (characteristics: multi-disciplinary; ≥ 2 healthcare providers; and multi-treatment; ≥ 2 components;** duration at least three months) [6,8] Health-related Quality of life Exacerbation action plan embedded in self-management intervention [4,32] Pulmonary Rehabilitation (characteristics: endurance and/ or strength exercise, 11 exercise therapy 36 ) [11,36] Self-management-Intervention (characteristic: iterative process with ≥ 2 components*) [5,7] Digital-based self-management-interventions (characteristic: behavior change intervention) [33] Tele-healthcare intervention: patients measure and/or report signs or symptoms [34] Home-care by COPD outreach nurse (characteristics: components of education, support, monitoring health, liaising with physician) [37] Interventions for integrated care (characteristics: multi-disciplinary; ≥ 2 healthcare providers; and multi-treatment; ≥ 2 components;** duration at least three months) [6,8] In malnourished patients: Nutritional supplementation [35] Stabilization of lung function Smoking Cessation [29] Notes: *components: smoking cessation, self-recognition of exacerbation, use of an exacerbation action plan, home-based physical activity, diet, medication, and dyspnea management; ** components: 1) self-management education eg, exacerbation management, 2) exercise training, 3) psychosocial intervention(s), 4) smoking cessation, 5) medication adherence, 6) dietary intervention, 7) structured follow-up, 8) multidisciplinary team and 9) reimbursement for provision of integrated care.…”