Self-Initiated Behavioral Act-Related Neuronal Activity in the Region of the Raphe Nuclei of the Cat

Kulichenko, A. M.; Павленко, В. Б.

doi:10.1023/b:neph.0000035969.92198.9f

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…The central neurotransmitter serotonin (5-HT) has been implicated in the motivational control of behaviour [1][2][3][4]. Several lines of research have shown that 5-HT, and its 5-HT 2C receptor in particular, plays an important role in regulating instrumental vigour.…”

Section: Introductionmentioning

confidence: 99%

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5-HT_2Creceptor perturbation has bidirectional influence over instrumental vigour and restraint

Haermson

Grima

Panayi

et al. 2020

Preprint

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The serotonin (5-HT) system, particularly the 5-HT2C receptor, has consistently been implicated in behavioural control. However, while some studies have focused on the role 5HT2C receptors plays in regulating motivation to work for reward, others have highlighted its importance in response restraint. To date, it is unclear how 5-HT transmission at this receptor regulates the balance of response invigoration and restraint in anticipation of future reward. In addition, it remains to be established how 5HT2C receptors gate the influence of internal versus cue-driven processes over reward-guided actions. To elucidate these issues, we investigated the effects of administering the 5HT2C receptor antagonist SB242084, both systemically and directly into the nucleus accumbens core (NAcC), in rats performing a Go/No-Go task for small or large rewards. The results were compared to administration of d-amphetamine into the NAcC, which has previously been shown to promote behavioural activation. Systemic perturbation of 5HT2C receptors – but crucially not intra-NAcC infusions – consistently boosted rats’ performance and instrumental vigour on Go trials when they were required to act. Concomitantly, systemic administration also reduced their ability to withhold responding for rewards on No-Go trials, particularly late in the holding period. Notably, these effects were often apparent only when the reward on offer was small. By contrast, inducing a hyperdopaminergic state in the NAcC with d-amphetamine strongly impaired response restraint on No-Go trials both early and late in the holding period, as well as speeding action initiation. Together, these findings suggest that 5HT2C receptor transmission, outside the NAcC, shapes the vigour of ongoing goal-directed action as well as the likelihood of responding as a function of expected reward.

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Section: Introductionmentioning

confidence: 99%

“…The central neurotransmitter serotonin (5-HT) has been implicated in the motivational control of behaviour (Mcelroy et al 1982; Soubrié 1986; Kulichenko and Pavlenko 2004; Cools et al 2011). Transmission at the 5-HT 2C receptor in particular may play a crucial role in this through the regulation of instrumental vigour – i.e.…”

Section: Introductionmentioning

confidence: 99%

5-HT_2Creceptor perturbation has bidirectional influence over instrumental vigour and restraint

Haermson

Grima

Panayi

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The central neurotransmitter serotonin (5-HT) has been implicated in the motivational control of behaviour (McElroy et al 1982 ; Soubrié 1986 ; Kulichenko and Pavlenko 2004 ; Cools et al 2011 ). Transmission at the 5-HT 2C receptor, in particular, may play a crucial role in this through the regulation of instrumental vigour—i.e.…”

Section: Introductionmentioning

confidence: 99%

5-HT2C receptor perturbation has bidirectional influence over instrumental vigour and restraint

et al. 2021

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The serotonin (5-HT) system, particularly the 5-HT2C receptor, has consistently been implicated in behavioural control. However, while some studies have focused on the role 5-HT2C receptors play in regulating motivation to work for reward, others have highlighted its importance in response restraint. To date, it is unclear how 5-HT transmission at this receptor regulates the balance of response invigoration and restraint in anticipation of future reward. In addition, it remains to be established how 5-HT2C receptors gate the influence of internal versus cue-driven processes over reward-guided actions. To elucidate these issues, we investigated the effects of administering the 5-HT2C receptor antagonist SB242084, both systemically and directly into the nucleus accumbens core (NAcC), in rats performing a Go/No-Go task for small or large rewards. The results were compared to the administration of d-amphetamine into the NAcC, which has previously been shown to promote behavioural activation. Systemic perturbation of 5-HT2C receptors—but crucially not intra-NAcC infusions—consistently boosted rats’ performance and instrumental vigour on Go trials when they were required to act. Concomitantly, systemic administration also reduced their ability to withhold responding for rewards on No-Go trials, particularly late in the holding period. Notably, these effects were often apparent only when the reward on offer was small. By contrast, inducing a hyperdopaminergic state in the NAcC with d-amphetamine strongly impaired response restraint on No-Go trials both early and late in the holding period, as well as speeding action initiation. Together, these findings suggest that 5-HT2C receptor transmission, outside the NAcC, shapes the vigour of ongoing goal-directed action as well as the likelihood of responding as a function of expected reward.

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Content of Serotonin in the Blood at High Physic Loadings as a Possible Factor Influencing Central Effects of This Monoamine

Dorofeyeva¹

2004

Neurophysiology

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Self-Initiated Behavioral Act-Related Neuronal Activity in the Region of the Raphe Nuclei of the Cat

Cited by 4 publications

References 15 publications

5-HT_2Creceptor perturbation has bidirectional influence over instrumental vigour and restraint

5-HT_2Creceptor perturbation has bidirectional influence over instrumental vigour and restraint

5-HT2C receptor perturbation has bidirectional influence over instrumental vigour and restraint

Content of Serotonin in the Blood at High Physic Loadings as a Possible Factor Influencing Central Effects of This Monoamine

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Self-Initiated Behavioral Act-Related Neuronal Activity in the Region of the Raphe Nuclei of the Cat

Cited by 4 publications

References 15 publications

5-HT2Creceptor perturbation has bidirectional influence over instrumental vigour and restraint

5-HT2Creceptor perturbation has bidirectional influence over instrumental vigour and restraint

5-HT2C receptor perturbation has bidirectional influence over instrumental vigour and restraint

Content of Serotonin in the Blood at High Physic Loadings as a Possible Factor Influencing Central Effects of This Monoamine

Contact Info

Product

Resources

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5-HT_2Creceptor perturbation has bidirectional influence over instrumental vigour and restraint

5-HT_2Creceptor perturbation has bidirectional influence over instrumental vigour and restraint