Self-Inducing Shape Memory Geometric Cues Embedded within Smart Hydroxyapatite-Based Biomimetic Matrices

Ripamonti, Ugo; Richter, P. W.; Thomas, Michael E.

doi:10.1097/01.prs.0000287133.43718.89

Cited by 41 publications

(90 citation statements)

References 33 publications

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“…As previously shown using biphasic biomimetic matrices [26], expression of mRNA species is followed by secretion and embedding of the osteogenic gene products, i.e. BMP-7, onto the biomimetic matrices resulting in the induction of bone formation as a secondary response.…”

Section: Discussionmentioning

confidence: 90%

“…The induction of bone formation, by combining soluble osteogenic molecular signals with different insoluble signals or substrata, is the essence of the tissue engineering paradigm. This and other studies on the intrinsic osteoinductivity of porous biomimetic matrices are changing the paradigm since the osteogenic signals of the TGF-b superfamily are not previously combined to the biomimetic matrices but rather self-expressed, secreted and embedded into specific geometric configurations of the matrices by differentiating osteoblastic-like cells which attach and differentiate onto the biomimetic substrata [10,11,19,26].…”

Section: Discussionmentioning

confidence: 96%

“…Anaesthetized animals were killed with an intravenous overdose of sodium pentobarbitone on days 60, 90 and 365, two animals per observation period as described [15,16,19,26]. Prior to carotid perfusion, heterotopic specimens were harvested and subjected to molecular, biochemical and histological analyses.…”

Section: Tissue Harvest Histology and Histomorphometrymentioning

confidence: 99%

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The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs

et al. 2009

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 96%

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The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs

et al. 2009

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“…Other characteristics such as carrier configurations, connectivity, pore size, and porosity also need to be considered. 34,95 To date, delivery systems have mainly been fabricated in diverse geometries such as three-dimensional matrices/scaffolds, injectable gels, micro/nanoparticulates, films and composites, and are basically classified as: [16][17][18][19]24,87,88,90,169,170 * reservoir systems; * environmentally responsive systems; * biologically inspired systems.…”

Section: Growth Factor Delivery Systems and Devicesmentioning

confidence: 99%

Localized delivery of growth factors for periodontal tissue regeneration: Role, strategies, and perspectives

Chen

Shelton

Jin

et al. 2009

Medicinal Research Reviews

131

111

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Difficulties associated with achieving predictable periodontal regeneration, means that novel techniques need to be developed in order to regenerate the extensive soft and hard tissue destruction that results from periodontitis. Localized delivery of growth factors to the periodontium is an emerging and versatile therapeutic approach, with the potential to become a powerful tool in future regenerative periodontal therapy. Optimized delivery regimes and well-defined release kinetics appear to be logical prerequisites for safe and efficacious clinical application of growth factors and to avoid unwanted side effects and toxicity. While adequate concentrations of growth factor(s) need to be appropriately localized, delivery vehicles are also expected to possess properties such as protein protection, precision in controlled release, biocompatibility and biodegradability, self-regulated therapeutic activity, potential for multiple delivery, and good cell/tissue penetration. Here, current knowledge, recent advances, and future possibilities of growth factor delivery strategies are outlined for periodontal regeneration. First, the role of those growth factors that have been implicated in the periodontal healing/regeneration process, general requirements for their delivery, and the different material types available are described. A detailed discussion follows of current strategies for the selection of devices for localized growth factor delivery, with particular emphasis placed upon their advantages and disadvantages and future prospects for ongoing studies in reconstructing the tooth supporting apparatus.

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“…According to literature, the geometry of the grafting material could represent a differentiating key-factor able to influence the clinical outcomes. In fact, several studies demonstrated that the surface geometry is a critical factor for cell adhesion and differentiation (9,10). In the light of these chemical and physical features, biomaterials with a surface geometry similar to human bone represent the last generation of synthetic devices.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis

Figliuzzi

Giudice

Pileggi

et al. 2016

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SummaryAim. Hydroxyapatite (PA) has a chemical composition and physical structure very similar to natural bone and therefore it has been considered to be the ideal biomaterial able to ensure a biomimetic scaffold to use in bone tissue engineering. The aim of this study is to clinically test hydroxyapatite used as osteoconductive biomaterial in the treatment of periodontal bone defects. Clinical and radiological evaluations were conducted at 6, 12 and 18 months after the surgery. Materials and methods. Forty patients with 2-and 3-wall intrabony pockets were enrolled in this study. PPD, CAL, radiographic depth (RD) and angular defects were preoperatively measured. After surgery, patients were re-evaluated every 6 months for 18 months. Statistical analyses were also performed to investigate any differences between preoperative and postoperative measurements. Results. Paired t-test samples conducted on the data obtained at baseline and 18 months after, showed significant (p<0.01) differences in each measurement performed. The role of preoperative RD was demonstrated to be a significant key factor (p<0.01). A relevant correlation between preoperative PPD and CAL gain was also found. Conclusions.Within the limitations of this study, the absence of anatomical variables, except the morphology of the bone defect, emphasizes the importance of the proper surgical approach and the graft material used.

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Self-Inducing Shape Memory Geometric Cues Embedded within Smart Hydroxyapatite-Based Biomimetic Matrices

Cited by 41 publications

References 33 publications

The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs

The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs

Localized delivery of growth factors for periodontal tissue regeneration: Role, strategies, and perspectives

Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis

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