Self-Indicating Polymer Prodrug Nanoparticles for pH-Responsive Drug Delivery in Cancer Cells and Real-Time Monitoring of Drug Release
Shibayan Kayal,
Prithwish Kola,
Juthi Pal
et al.
Abstract:Amphiphilic self-indicating and responsive polymerbased prodrugs have generated much interest as potential stimuliresponsive intelligent drug delivery systems (DDS) due to their ability to selectively deliver drugs to the cancer cells and to monitor real-time cellular uptake of the drug by imaging technique(s). In this direction, we have synthesized a new pHresponsive N-vinyl-2-pyrrolidone and coumarin-based fluorescent self-indicating polymeric prodrug (SIPD), poly(NVP)-b-poly-(FPA.DOX-r-FPA-r-CA). This block… Show more
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