Self‐Immolative Dendrimers

Amir, Roey J.; Pessah, Neta; Shamis, Marina; Shabat, Doron

doi:10.1002/anie.200351962

Cited by 303 publications

(273 citation statements)

References 15 publications

(9 reference statements)

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“…The solvent was then removed under reduced pressure to yield the crude product as a yellow oil. Flash chromatography (Hex/EtOAc, 90:10) gave the pure final product (0.595 g, 28%) as a colorless oil: 1 3 mmol) were dissolved in a mixture of anhydrous methylene chloride (15 mL) and anhydrous DMF (9 mL). N,N-Dicyclohexylcarbodiimide was quickly added to the reaction mixture, which was stirred under argon overnight.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Self-Immolative Aryl Phthalate Esters

2012

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We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications. ABSTRACT: We report that aryl phthalate esters are robust selfimmolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications. Disciplines

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Self-Immolative Aryl Phthalate Esters

2012

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“…Although the enhanced effect that stems from many identical end groups being present simultaneously at the same place is of great importance, the combination of utilizing the multivalency and the precise architecture as an active framework able functioning more than just a scaffold, opens the way for novel and exciting dendrimeric devices. Two such concepts that conceal both the multivalency and the active framework features are the use of dendrimers as light harvesting antennae [19][20][21][22], and as molecular amplifiers [7,21,23,24]. The latter use of dendrimers is based on disintegrating the dendrimeric skeleton into its subunits, thus releasing all of its functional end-groups as a result of a signal initiated at the core of the dendrimer.…”

Section: Figurementioning

confidence: 99%

Some new aspects of dendrimer applications

Flomenbom

Amir

Shabat

et al. 2005

Journal of Luminescence

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Dendrimers are characterized by special features that make them promising candidates for many applications. Here we focus on two such applications: dendrimers as light harvesting antennae, and dendrimers as molecular amplifiers, which may serve as novel platforms for drug delivery. Both applications stem from the unique structure of dendrimers. We present a theoretical framework based on the master equation within which we describe these applications. The quantities of interest are the first passage time (FPT) probability density function (PDF), and its moments. We examine how the FPT PDF and its characteristics depend on the geometric and energetic structures of the dendrimeric system. In particular, we investigate the dependence of the FPT properties on the number of generations (dendrimer size), and the system bias. We present analytical expressions for the FPT PDF for very efficient dendrimeric antennae and for dendrimeric amplifiers. For these cases the mean first passage time scales linearly with the system length, and fluctuations around the mean first passage time are negligible for large systems. Relationships of the FPT to light harvesting process for other types of system-bias are discussed.

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“…[2] The amount of drug activated at the targeted tissue is dependent on the rate and concentration of the specific enzyme. To overcome this limitation, our group [3,4] and two others [5,6] have designed dendritic units that are able to release several drug molecules with a single enzymatic cleavage. We have also demonstrated the potential of the dendritic platform with the first bioactivation of dimeric prodrugs.…”

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confidence: 99%