Self-healing Hydrogels Based on Dynamic Chemistry and Their Biomedical Applications

Zhang, Yaling; Yang, Bin; Xu, Li Chong; Zhang, Xiao‐Yong; Tao, Lei; Wei, Yu

doi:10.6023/a13010139

Cited by 24 publications

(14 citation statements)

References 20 publications

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“…In our previous work, we developed a self‐healing hydrogel by crosslinking acrylamide‐modified chitin with oxidized alginate and investigated different parameters for instance pH and mass ratio of two polymers on the self‐healing ability . Though self‐healable polysaccharide hydrogels produced based on dynamic covalent chemistry have been widely investigated, these hydrogels lose their self‐repair ability and become brittle after completely crosslinking. These drawbacks hinder the polysaccharide hydrogels to be practically applied in different biomedical fields.…”

Section: Introductionmentioning

confidence: 99%

Flexible Polysaccharide Hydrogel with pH‐Regulated Recovery of Self‐Healing and Mechanical Properties

Ding

Shi

et al. 2017

Macro Materials & Eng

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A self‐healable hydrogel with recoverable self‐healing and mechanical properties is reported. The hydrogel (coded as ACSH) crosslinked by Schiff base linkage contains two polysaccharides of acrylamide‐modified chitosan (AMCS) and oxidized alginate (ADA). Self‐healing and mechanical properties are heavily influenced by the crosslinking time. The hydrogel crosslinked for 2 h possesses better mechanical and self‐healing properties than hydrogel crosslinked for 24 h. Macroscopic test shows that hydrogel without self‐healing ability can recover the self‐repair and mechanical properties by adjusting the pHs. The recovery of self‐healing and mechanical properties relies on the pH sensitivity of the Schiff base linkage. Adjusting the pH to acid, the Schiff base linkage becomes unstable and breaks. Regulating the pH to neutral, reconstruction of Schiff base linkage leads to recovery of the self‐repair and mechanical properties. The recoverable self‐healing property can be cycled once breakage and reconstruction of the Schiff base linkage can be conducted. In addition, this study demonstrates that the hydrogel can be remodeled into different shapes based on self‐healing property of the hydrogel. It is anticipated that this self‐healable hydrogel with recoverable self‐healing and mechanical properties may open a new way to investigate self‐healing hydrogel and find potential applications in different biomedical fields.

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Section: Introductionmentioning

confidence: 99%

Flexible Polysaccharide Hydrogel with pH‐Regulated Recovery of Self‐Healing and Mechanical Properties

Ding

Shi

et al. 2017

Macro Materials & Eng

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“…21 However, traditional hydrogel does not possess self-healing properties. Many researchers have reported the preparation of self-healing hydrogels, 22,23 which have widely attracted the interests of scientists in designing the internal structure of hydrogel with reversible covalent bonding systems (Diels Alder chemistry 24 and acylhydrazone bonds 25 ) and noncovalent bonds (p-p stacking, 26 hydrogen bond, 27,28 electrostatic interactions, 29,30 and hydrophobic interactions 31,32 ). Zhang et al 33 determined that poly(vinyl alcohol) (PVA) hydrogel prepared using the freezing thawing method could self-repair at room temperature without a stimulus or healing agent.…”

Section: Introductionmentioning

confidence: 99%

Facile fabrication of a magnetic self-healing poly(vinyl alcohol) composite hydrogel

et al. 2017

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“…To fully explore the fascinating nature of resuscitation, numerous materials with self-healing system have been studied constantly, [2] and many related applications have been established so far, such as anti-corrosive [3][4][5][6] and superhydrophobic coatings [7,8] etc. Various materials, including organic, inorganic and polymer, have been effectively adopted to mimic self-healing properties in macroscopic scale by several popular techniques, such as, sol-gel, [1,9] self assembling, [7,10,11] encapsulation, [12][13][14] polymer grafting and processing [15,16] and hybrid [4,17] etc. What's lacking is a detailed study on self-healing in molecular level, which usually requires systematic study on surface and interface with sophisticated techniques.…”

Section: Introductionmentioning

confidence: 99%

Light‐Triggered Molecular Level Self‐Healing Spiropyran Thin Film

et al. 2013

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Spiropyran thin film with capability of light-triggered molecular level self-healing has been successfully designed and fabricated by Langmuir-Blodgett technology. Various remarkable properties of thin film shrinkage or height increase or self-healing nano-defect recovery under different fabrication conditions have been observed. In addition, further evidence of the self-healing, which resulted from the movement of spiropyran molecules (such as "standing" "lie-down" and "tip-toes" etc.) on the substrate, has also been observed from the reversible contact angle change of the thin film.

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Self-healing Hydrogels Based on Dynamic Chemistry and Their Biomedical Applications

Cited by 24 publications

References 20 publications

Flexible Polysaccharide Hydrogel with pH‐Regulated Recovery of Self‐Healing and Mechanical Properties

Flexible Polysaccharide Hydrogel with pH‐Regulated Recovery of Self‐Healing and Mechanical Properties

Facile fabrication of a magnetic self-healing poly(vinyl alcohol) composite hydrogel

Light‐Triggered Molecular Level Self‐Healing Spiropyran Thin Film

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