Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration

Abstract

Guided bone regeneration (GBR) is widely used in treating oral bone defects to exclude the influence of non-osteogenic tissue on the bone healing process. The traditional method of GBR with a titanium mesh to treat large-area bone defects is limited by the deficiency of increased trauma and costs to patients. Herein, a bi-layered scaffold for GBR composed of a fiber barrier layer and a self-healing hydrogel repair layer is successfully fabricated. The barrier layer is a fibrous membrane material with specific porosity constructed by electrospinning, while the functional layer is a self-healing hydrogel material formed by multiple dynamic covalent bonds. The system can provide an osteogenic microenvironment by preventing the infiltration of connective tissue to bone defects, maintain the stability of the osteogenic space through the self-healing property, and regulate the release of bioactive substances in the dynamic physical condition, which is beneficial to osteoblast proliferation, differentiation, and bone regeneration. This study focused on exploring the effects of different crosslinkers and bonding methods on the comprehensive properties of hydrogels. and proved that the hybrid scaffold system has good biocompatibility, cell barrier function and can enhance bone regeneration activity. Thereby it could be a promising clinical strategy for bone regeneration.

Biomimetic Approach for Enhanced Mechanical Properties and Stability of Self-Mineralized Calcium Phosphate Dibasic–Sodium Alginate–Gelatine Hydrogel as Bone Replacement and Structural Building Material

“…Lacroix, J.; etc., 2013 [81] also proposed the use of bioactive glasses as green and safe in situ scaffolds for bone tissue engineering. One study [82] proposed self-healing sustainable hydrogels for guided bone regeneration (GBR), and a few other pieces of literature proposed the use of self-mineralized materials as building material in architecture applications either from existing cementous mineralized materials based on the CO 2 to calcium carbonate reactions [83,84] or by inducing mineralization through a bioactive agent as bacteria or fungi [4,85]. However, the current study goes beyond the literature by not only proposing a sustainable composed hydrogel for self-mineralized material but also by providing sustainable minimized materials and processes in preparing this self-mineralized material.…”

Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

“…This system creates a conducive environment for bone formation by blocking connective tissue infiltration, maintaining stability in the bone-forming space, and controlling the release of bioactive substances to promote osteoblast activity and bone regeneration (Figure 10C). [175] To overcome limitations in silk-based hydrogel preparation, researchers are using metal-ligand coordination chemistry to create hydrogels under physiological conditions. This involves assembling silk fibroin microfibers with polysaccharide crosslinkers and forming reversible crosslinks with a calcium phosphate coating on the microfibers.…”

Self-healing hydrogels for bone defect repair

“…Thus, it can be used for a limited number of times and cannot be repeated indenitely. 127 Accordingly, autonomous self-healing has become a hot research topic in recent years owing to the diversity of potential autonomic interactions. 128,129 Early SHHs mainly release healing agents via microcapsules or microtubules, but these methods can only achieve sufficient healing once or twice.…”