Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials

Li, Shangzhi; Pei, Minjie; Wan, Tingting; Yang, Hongjun; Gu, Shaojin; Tao, Yue; Liu, Xin; Zhou, Yingshan; Xu, Weilin; Xiao, Pu

doi:10.1016/j.carbpol.2020.116922

Cited by 160 publications

(110 citation statements)

References 47 publications

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“…As a result, the hydrogels exhibited excellent self-healing capacity, faster gel formation, and better mechanical properties by increasing the cross-linker. Thus, the hydrogels were promising for various biomedical applications [85]. In addition, Bao et al (2021) prepared a hydrogel film of oxi-HA/GP for topical ocular stepwise release of dexamethasone and levofloxacin as an alternative to conventional ophthalmic dosage forms treating postoperative endophthalmitis [86].…”

Section: Oxi-ha Cross-linkings and Conjugationsmentioning

confidence: 99%

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

2021

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Hyaluronic acid (HA) is a natural polyelectrolyte abundant in mammalian connective tissues, such as cartilage and skin. Both endogenous and exogenous HA produced by fermentation have similar physicochemical, rheological, and biological properties, leading to medical and dermo-cosmetic products. Chemical modifications such as cross-linking or conjugation in target groups of the HA molecule improve its properties and in vivo stability, expanding its applications. Currently, HA-based scaffolds and matrices are of great interest in tissue engineering and regenerative medicine. However, the partial oxidation of the proximal hydroxyl groups in HA to electrophilic aldehydes mediated by periodate is still rarely investigated. The introduced aldehyde groups in the HA backbone allow spontaneous cross-linking with adipic dihydrazide (ADH), thermosensitivity, and noncytotoxicity to the hydrogels, which are advantageous for medical applications. This review provides an overview of the physicochemical properties of HA and its usual chemical modifications to better understand oxi-HA/ADH hydrogels, their functional properties modulated by the oxidation degree and ADH concentration, and the current clinical research. Finally, it discusses the development of biomaterials based on oxi-HA/ADH as a novel approach in tissue engineering and regenerative medicine.

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Section: Oxi-ha Cross-linkings and Conjugationsmentioning

confidence: 99%

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

2021

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“…ECM hydrogels with self-healing properties have attracted increasing attention in biomedical fields because self-healing is one of the fundamental properties of living tissues. The self-healing ability of hydrogels with dynamic reversible crosslinks allows them to recover their structures and functionalities after injection [ 20 , 21 ]. Moreover, the self-healing ability of hydrogels greatly extends their lifespan in vivo [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury

Luo

Fan

Liu

et al. 2022

Bioactive Materials

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Injectable biomaterial-based treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury (SCI) by bridging cavity spaces. However, there are limited reports of injectable, electroconductive hydrogels with self-healing properties being employed for the treatment of traumatic SCI. Hence, a natural extracellular matrix (ECM) biopolymer (chondroitin sulphate and gelatin)-based hydrogel containing polypyrrole, which imparted electroconductive properties, is developed for traumatic SCI repair. The resulting hydrogels showed mechanical (~928 Pa) and conductive properties (4.49 mS/cm) similar to natural spinal cord tissues. Moreover, the hydrogels exhibited shear-thinning and self-healing abilities, which allows it to be effectively injected into the injury site and to fill the lesion cavity to accelerate the tissue repair of traumatic SCI. In vitro, electroconductive ECM hydrogels promoted neuronal differentiation, enhanced axon outgrowth, and inhibited astrocyte differentiation. The electroconductive ECM hydrogel activated endogenous neural stem cell neurogenesis in vivo (n = 6), and induced myelinated axon regeneration into the lesion site via activation of the PI3K/AKT and MEK/ERK pathways, thereby achieving significant locomotor function restoration in rats with spinal cord injury (p < 0.001, compared to SCI group). Overall, the injectable self-healing electroconductive ECM-based hydrogels developed in this study are ideal biomaterials for treatment of traumatic SCI.

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“…Imine‐crosslinked hydrogels are self‐healing and recover applied stress, indicating viscoelasticity. [ 156 ] For example, imine‐crosslinked collagen gels showed greater stress relaxation than photo‐crosslinked methacrylated‐collagen (Figure 3d). [ 47 ] The effect of chemical environment on the imine linkages is less understood in terms of its effect on modulating viscoelasticity of the hydrogel.…”

Section: Dynamic Chemistry Viscoelasticity and 3d Cell Culturementioning

confidence: 99%

Designing Hydrogels for 3D Cell Culture Using Dynamic Covalent Crosslinking

Rizwan

Baker

Shoichet

2021

Adv Healthcare Materials

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Designing simple biomaterials to replicate the biochemical and mechanical properties of tissues is an ongoing challenge in tissue engineering. For several decades, new biomaterials have been engineered using cytocompatible chemical reactions and spontaneous ligations via click chemistries to generate scaffolds and water swollen polymer networks, known as hydrogels, with tunable properties. However, most of these materials are static in nature, providing only macroscopic tunability of the scaffold mechanics, and do not reflect the dynamic environment of natural extracellular microenvironment. For more complex applications such as organoids or co‐culture systems, there remain opportunities to investigate cells that locally remodel and change the physicochemical properties within the matrices. In this review, advanced biomaterials where dynamic covalent chemistry is used to produce stable 3D cell culture models and high‐resolution constructs for both in vitro and in vivo applications, are discussed. The implications of dynamic covalent chemistry on viscoelastic properties of in vitro models are summarized, case studies in 3D cell culture are critically analyzed, and opportunities to further improve the performance of biomaterials for 3D tissue engineering are discussed.

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Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials

Cited by 160 publications

References 47 publications

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury

Designing Hydrogels for 3D Cell Culture Using Dynamic Covalent Crosslinking

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