Self-healing, antibacterial, and dual cross-linked multilayer films for microcapsule-based controllable drug release applications

Xuan, Hongyun; Zhu, Yue; Ren, Jiaoyu; Dai, Wei; Ge, Liqin

doi:10.1016/j.apsusc.2018.12.278

Cited by 17 publications

(16 citation statements)

References 40 publications

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“…In addition, the L929 cells were also cultured in 96-well plates according to the above procedure, and the CCK-8 test was performed according to the method in the literature. 23…”

Section: Biocompatibility Testmentioning

confidence: 99%

An antibacterial and biocompatible multilayer biomedical coating capable of healing damages

et al. 2020

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“…In addition, the L929 cells were also cultured in 96-well plates according to the above procedure, and the CCK-8 test was performed according to the method in the literature. 23…”

Section: Biocompatibility Testmentioning

confidence: 99%

An antibacterial and biocompatible multilayer biomedical coating capable of healing damages

et al. 2020

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“…Analogous to the structures present in biological systems at different length scales, a remarkable progress was registered in developing new functional materials for regenerative medicine, pharmaceutics or electronics and advanced technologies [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Due to high elasticity, superabsorbence and excellent mechanical properties, synthetic hydrogels with porous structure are widely used in biomedical applications for controlled drug release, tissue engineering, implantable devices, wound dressings, contact lenses, biosensors or actuators, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Due to high elasticity, superabsorbence and excellent mechanical properties, synthetic hydrogels with porous structure are widely used in biomedical applications for controlled drug release, tissue engineering, implantable devices, wound dressings, contact lenses, biosensors or actuators, etc. [ 10 , 11 , 12 , 13 , 14 ]. In particular, various biomaterials can be easily obtained by environmental-friendly chemical or physical procedures applied to poly(vinyl alcohol) (PVA) [ 15 , 16 ], or to various combinations of PVA with other macromolecules or small molecules [ 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels

Bercea¹

2021

Polymers

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The paper presents the viscoelastic properties of new hybrid hydrogels containing poly(vinyl alcohol) (PVA), hydroxypropylcellulose (HPC), bovine serum albumin (BSA) and reduced glutathione (GSH). After heating the mixture at 55 °C, in the presence of GSH, a weak network is formed due to partial BSA unfolding. By applying three successive freezing/thawing cycles, a stable porous network structure with elastic properties is designed, as evidenced by SEM and rheology. The hydrogels exhibit self-healing properties when the samples are cut into two pieces; the intermolecular interactions are reestablished in time and therefore the fragments repair themselves. The effects of the BSA content, loaded deformation and temperature on the self-healing ability of hydrogels are presented and discussed through rheological data. Due to their versatile viscoelastic behavior, the properties of PVA/HPC/BSA hydrogels can be tuned during their preparation in order to achieve suitable biomaterials for targeted applications.

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“…[5] In particular, fused deposition modeling (FDM) allows the manufacturing of objects by the to minimize the amount of material used. [22,23] LbL has been widely used in the biomedical sector, including substrates with tunable properties for theranostics [24] or the design of micropatterned protein arrays. [25] LbL has exploited the use of polysaccharides to produce biodegradable LbL build-ups from bio-based materials.…”

Section: Introductionmentioning

confidence: 99%

“…[ 18–20 ] This technology is known since 1997 [ 21 ] and consists in the fabrication of thin films via electrostatic or supramolecular interactions of different polymers, which allows to minimize the amount of material used. [ 22,23 ] LbL has been widely used in the biomedical sector, including substrates with tunable properties for theranostics [ 24 ] or the design of micropatterned protein arrays. [ 25 ]…”

Section: Introductionmentioning

confidence: 99%

Design of a Bio‐Based Device for Micro Total Analysis Combining Fused Deposition Modeling and Layer‐by‐Layer Technologies

León

Frutos

Molina

2020

Macro Materials & Eng

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Compared to other fabrication methods such as micromolding [7] or soft lithography, [8] objects manufactured via FDM are produced in their final shape without any external template, additional tools, or further postprocessing. Since FDM does not require any mastermold, it allows the fabrication of complex, tailorable lattices with high reproducibility, such as highly hollow or gyroidal structures. [9] FDM feedstock is commodity plastics, avoiding the use of hazard or expensive compounds. Moreover, FDM printers are more economic and relatively easy to use than most of other (micro)fabrication equipment. The printed objects are previously designed using a software and all the information needed for fabrication is contained within a computer assisted design file. These designs can be easily modified to meet the quick changing needs of the market, allowing high flexibility in the product and reducing the product development process. [10] Since 3D printing technologies emerged, polylactic acid (PLA) has become one of the most widely used materials in the FDM technology due to its cost, biodegradability, and good mechanical properties. [11] PLA can be manufactured from natural sources as sugarcane or corn starch and possesses mechanical properties comparable to fossil-fuel derived polystyrene. [12] Among its limitations, it presents a low maximum service temperature (≈60 °C), which narrows its use in engineering applications. [13] However, it can be used as structural matrix when working at room or human body temperature. Bio-based polymers, including PLA, have been printed to fabricate tablets, [14] scaffolds, [15] or even organs individually adapted for each patient. [16] In addition, since additive manufacturing techniques emerged, there is a growing number of initiatives to fabricate different equipment and laboratory supplies in house, [17] which would allow reducing the production chain, saving time and money. Another important factor to consider in the design of micro total analysis systems is the surface modification of the material so it can selectively adsorb the target biomolecule. Among other alternatives, the LbL technology is an interesting option which allows the modification of large surfaces in an inexpensive manner. [18-20] This technology is known since 1997 [21] and consists in the fabrication of thin films via electrostatic or supramolecular interactions of different polymers, which allows In this paper a methodology is presented to fabricate a micropatterned device made of bio-based polymers (polylactic acid, sodium alginate (ALG), and chitosan (CHI)) suitable for micro total analysis. Fused deposition modeling and layer-by-layer technologies are combined to create tailorable devices with submillimetric controlled well size that can be rapidly prepared in house. As proof of concept, the influence of immobilization of ALG/CHI bilayers in the selective adsorption of alkaline phosphatase and its activity is studied. Due to the noncovalent nature of these interactions, it is proven that these devices ...

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Self-healing, antibacterial, and dual cross-linked multilayer films for microcapsule-based controllable drug release applications

Cited by 17 publications

References 40 publications

An antibacterial and biocompatible multilayer biomedical coating capable of healing damages

An antibacterial and biocompatible multilayer biomedical coating capable of healing damages

Self-Healing Behavior of Polymer/Protein Hybrid Hydrogels

Design of a Bio‐Based Device for Micro Total Analysis Combining Fused Deposition Modeling and Layer‐by‐Layer Technologies

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