Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment

Kommuru, Thirumala R.; Gurley, Bill J.; Khan, Mansoor A.; Reddy, Indra K.

doi:10.1016/s0378-5173(00)00614-1

Cited by 519 publications

(295 citation statements)

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“…Selection of a suitable self-emulsifying formulation depends upon the assessment of the solubility of the drug in various media, the area of the self-emulsifying region as obtained in the 110 pseudoternary phase diagrams, and droplet size distribution of the resultant emulsion following self-emulsification (Kommuru et al, 2001). …”

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Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Villar

Naveros

Campmany

et al. 2012

International Journal of Pharmaceutics

137

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Self nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the formulation variables, X1 (Cremophor® EL), X2 (Capmul® MCM -C8), and X3 (lemon essential oil). Systems were assessed for visual characteristics (emulsification efficacy), turbidity, droplet size, polydispersity index and drug release. Different pH media were also assayed for optimization. Following optimization, the values of formulation components (X1, X2, and X3) were 32. 43%, 29.73% and 21.62 %, respectively (16.22% of gemfibrozil). Transmission electron microscopy demonstrated spherical droplet morphology. SNEEDS release study was compared to commercial tablets. Optimized SNEDDS formulation of gemfibrozil showed a significant increase in dissolution rate compared to conventional tablets. Both formulations followed Weibull mathematical model release with a significant difference in td parameter in favour of the SNEDDS. Equally amodelistic parameters were calculated being the dissolution efficiency significantly higher for SNEDDS, confirming that the developed SNEDDS formulation was superior to commercial formulation with respect to in vitro dissolution profile. This paper provides an overview of the SNEDDS of the gemfibrozil as a promising alternative to improve oral absorption. She is an expert in nanotechnology (colloids and nanoparticles) with a wide experience. She has extensive curriculum of published paper about this subject Jose Luis Arias Mediano Ph. D. Professor reseracher, Pharmacy and Pharmaceutical Technology , University of Granada jlarias@ugr.es He is an expert in nanotechnology (colloids and nanoparticles) with a wide experience in this type of investigation. Also is reviewer in specialized pharmaceutical journal. He is an expert in nanotechnology (colloids and nanoparticles) with a wide experience in this type of investigation. Also is reviewer of Pharmaceutical science journals. IJP AUTHOR CHECKLISTDear Author, It frequently happens that on receipt of an article for publication, we find that certain elements of the manuscript, or related information, is missing. This is regrettable of course since it means there will be a delay in processing the article while we obtain the missing details.In order to avoid such delays in the publication of your article, if accepted, could you please run through the list of items below and make sure you have completed the items. Overall Manuscript Electronic artwork format? ---------------------------------------------------TIFF

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“…Their self-emulsifying properties were studied using a modified and adopted method of visual examination reported by Craig et al (1995) and utilized in others investigations (Kommuru et al, 2001). Briefly, 1g of formulation was introduced into 4 mL of distilled water in a glass beaker at 25 ºC and the contents were mixed gently with a magnetic stir bar.…”

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confidence: 99%

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Villar

Naveros

Campmany

et al. 2012

International Journal of Pharmaceutics

137

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“…-The liquid SEDDS/SNEDDS was added gradually and blended with the adsorbent NUS2 at the following fi xed fi nal SEDDS/SNEDDS to adsorbent appropriate mass ratio of 50/50, 60/40 and 70/30 (%, m/m). Briefl y, a fi xed amount of liquid SEDDS/SNEDDS was initially added to and mixed with NUS2 (20). The batch size of each blend was varied according to the quantity of the adsorbent and was categorized based on the fl owability of the powder.…”

Section: Methodsmentioning

confidence: 99%

Dissolution improvement of solid self-emulsifying drug delivery systems of fenofi brate using an inorganic high surface adsorption material

Shazly

Kazi

2015

Acta Pharmaceutica

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Dissolution improvement of solid self-emulsifying drug delivery systems of fenofi brate using an inorganic high surface adsorption materialSolidifi cation of lipid formulations using adsorbents is a recent technique a racting great interest due to its favourable properties including fl exibility in dose division, reduction of intra-subject and inter-subject variability, improvement in effi cacy/safety profi le and enhancement of physical/ chemical stability. The current study aims to convert liquid self-emulsifying/nanoemulsifying drug delivery systems (SEDDS/SNEDDS) into solid SEDDS/SNEDDS and to assess how adsorption of the drug onto an inorganic high surface area material, Neusilin ® grade US2 (NUS2), aff ects its in vitro dissolution performance. Lipid formulation classifi cation systems (LFCS) Type III formulations were designed for the model anti-cholesterol drug fenofi brate. NUS2 was used to solidify the SEDDS/SNEDDS. Particle size and SEM analyses of solid SEDDS/SNEDDS powder were carried out to investigate the adsorption effi ciency. In vitro dissolution studies were conducted to compare the developed formulations with the marketed product. The results of characterization studies showed that the use of 50 % (m/m) adsorbent resulted in superior fl owability and kept the drug stable is amorphous state. Dissolution studies allow the conclusion that the formulation containing a surfactant of higher water solubility (particularly, Type IIIB SNEDDS) has comparably faster and higher release profi les than Type IIIA (SEDDS) and marketed product.Keywords: self-emulsifying/nanoemulsifying drug delivery systems, fenofi brate, in vitro dissolution test, solidifi cation technique, adsorptionLipid-based dosage forms have gained high priority and become more prominent in the pharmaceutical industry in recent years (1-4). Lipids have been used as carriers in various delivery systems for drug administration, including solutions, suspensions, emulsions, self-emulsifying systems, microemulsions and, recently, solid dosage forms (via

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“…Hence, it is a challenging task to formulate a suitable drug delivery system of highly poor water soluble drugs 3 , oral bioavailability of water insoluble drugs is now come under BCS (Biopharmaceutical system classification) class II (High Permeability, Low Solubility & class IV (Low Permeability, Low Solubility 4 .These problems can be overcome by various drug delivery strategies which include size reduction, formation of salt, β-cyclodextrins, Nano particulate systems and solid dispersions. Further, these approaches utilize surfactants, lipids, permeation enhancers [5][6][7] . SEDDS are homogenous dispersion consisting of solid or liquid surfactants, synthetic or natural oils alternatively either co-solvents/surfactants and one or more hydrophilic solvents.…”

Section: Introductionmentioning

confidence: 99%

Formulation and in Vitro Characterisation of Self Emulsifying Drug Delivery System of Diclofenac for the Enhancement of Dissolution and Solubility

Chowdary¹

2017

IJRASET

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Diclofenac , non-steroidal anti-inflammatory drug (NSAID) belongs to BCS Class II drug with low dissolution and poor aqueous solubility. The main aim of the present study was to improve the solubility and dissolution rate of diclofenac using self-emulsifying drug delivery technique. Micro emulsion region was formed by preparing the ternary phase diagram. Ratio 0.15:0.85 , 0.5:0.5 and 0.3:0.7 was selected as the self-emulsification region for the development of formulation . Drugexcipient studies were performed by FT-IR .Parameters were evaluated include time of emulsification , freezing and thawing and dissolution. The present research work describes SEDDS of Diclofenac using olive oil, Tween 20 and PEG200 prepared by simple vortex in the mixture at 40 °c and packed in hard gelatine capsule shell of 00 size. In vitro dissolution was carried out using USPII by 6.8 pH buffer at 75 RPM and samples were measured at 276 nm using UV-Visible spectroscopy. From the studies the optimized SEDDS was composed of 30% oil, 45% Surfactant and 25% Co surfactant. The optimized formulation was found to be showing significant improvement in drug release and had 24 seconds self-emulsification time , having drug content 101.16% and complete 99.01% drug release in 60 minutes.

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Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment

Cited by 519 publications

References 24 publications

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Dissolution improvement of solid self-emulsifying drug delivery systems of fenofi brate using an inorganic high surface adsorption material

Formulation and in Vitro Characterisation of Self Emulsifying Drug Delivery System of Diclofenac for the Enhancement of Dissolution and Solubility

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