Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability

Kohli, Kanchan; Chopra, Sunny; Dhar, Deepika; Arora, Saurabh; Khar, Roop K.

doi:10.1016/j.drudis.2010.08.007

Cited by 335 publications

(169 citation statements)

References 56 publications

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“…35 The PDI ranged from 0.0 to 1.0, representing the uniformity of droplet size. The closer to zero the PDI value, the more homogeneous the droplets are.…”

Section: Characteristics Of Nanoemulsionsmentioning

confidence: 99%

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Zhao¹,

Wei²,

Huang³

et al. 2013

IJN

109

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“…35 The PDI ranged from 0.0 to 1.0, representing the uniformity of droplet size. The closer to zero the PDI value, the more homogeneous the droplets are.…”

Section: Characteristics Of Nanoemulsionsmentioning

confidence: 99%

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Zhao¹,

Wei²,

Huang³

et al. 2013

IJN

109

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“…Lipid based formulations represents a solution to delivery poorly soluble actives, among these lipid based systems, the self nanoemulsifying drug delivery systems (SNEDDS) are considered as promising technology to improve the rate and extent of absorption of poorly water soluble drugs (Singh et al, 2010;Hong, et al, 2006). This poorly water-soluble active behaves differently in similar vehicles, thus highlighting the need to assess 95 candidate compounds on an individual basis (Kohli et al, 2010).…”

mentioning

confidence: 99%

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Villar

Naveros

Campmany

et al. 2012

International Journal of Pharmaceutics

137

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Self nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the formulation variables, X1 (Cremophor® EL), X2 (Capmul® MCM -C8), and X3 (lemon essential oil). Systems were assessed for visual characteristics (emulsification efficacy), turbidity, droplet size, polydispersity index and drug release. Different pH media were also assayed for optimization. Following optimization, the values of formulation components (X1, X2, and X3) were 32. 43%, 29.73% and 21.62 %, respectively (16.22% of gemfibrozil). Transmission electron microscopy demonstrated spherical droplet morphology. SNEEDS release study was compared to commercial tablets. Optimized SNEDDS formulation of gemfibrozil showed a significant increase in dissolution rate compared to conventional tablets. Both formulations followed Weibull mathematical model release with a significant difference in td parameter in favour of the SNEDDS. Equally amodelistic parameters were calculated being the dissolution efficiency significantly higher for SNEDDS, confirming that the developed SNEDDS formulation was superior to commercial formulation with respect to in vitro dissolution profile. This paper provides an overview of the SNEDDS of the gemfibrozil as a promising alternative to improve oral absorption. She is an expert in nanotechnology (colloids and nanoparticles) with a wide experience. She has extensive curriculum of published paper about this subject Jose Luis Arias Mediano Ph. D. Professor reseracher, Pharmacy and Pharmaceutical Technology , University of Granada jlarias@ugr.es He is an expert in nanotechnology (colloids and nanoparticles) with a wide experience in this type of investigation. Also is reviewer in specialized pharmaceutical journal. He is an expert in nanotechnology (colloids and nanoparticles) with a wide experience in this type of investigation. Also is reviewer of Pharmaceutical science journals. IJP AUTHOR CHECKLISTDear Author, It frequently happens that on receipt of an article for publication, we find that certain elements of the manuscript, or related information, is missing. This is regrettable of course since it means there will be a delay in processing the article while we obtain the missing details.In order to avoid such delays in the publication of your article, if accepted, could you please run through the list of items below and make sure you have completed the items. Overall Manuscript Electronic artwork format? ---------------------------------------------------TIFF

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“…Droplet size measurements indicated that the lecithin-surfactant systems can produce nanosized droplets with narrow size distribution, leading to an increase of the emulsion stability. The charge on an oil droplet is negative due to the presence of free fatty acids in the formulation [1,18].…”

Section: Discussionmentioning

confidence: 99%

Development of an in Vitro System to Simulate the Adsorption of Self-Emulsifying Tea (Camellia oleifera) Seed Oil

et al. 2016

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Abstract:In this study, tea (Camellia oleifera) seed oil was formulated into self-emulsifying oil formulations (SEOF) to enhance the aqueous dispersibility and intestinal retention to achieve higher bioavailability. Self-emulsifying tea seed oils were developed by using different concentrations of lecithin in combination with surfactant blends (Span ® 80 and Tween ® 80). The lecithin/surfactant systems were able to provide clear and stable liquid formulations. The SEOF were investigated for physicochemical properties including appearance, emulsion droplets size, PDI and zeta potential. The chemical compositions of tea seed oil and SEOF were compared using GC-MS techniques. In addition, the oil adsorption measurement on artificial membranes was performed using a Franz cell apparatus and colorimetric analysis. The microscopic structure of membranes was observed with scanning electron microscopy (SEM). After aqueous dilution with fed-state simulated gastric fluid (FeSSGF), the droplet size of all SEOF was close to 200 nm with low PDI values and the zeta potential was negative. GC-MS chromatograms revealed that the chemical compositions of SEOF were not significantly different from that of the original tea seed oil. The morphological study showed that only the SEOF could form film layers. The oil droplets were extracted both from membrane treated with tea seed oil and the SEOF in order to evaluate the chemical compositions by GC-MS.

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Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability

Cited by 335 publications

References 56 publications

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil

Development of an in Vitro System to Simulate the Adsorption of Self-Emulsifying Tea (Camellia oleifera) Seed Oil

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