Self-doped polyaniline-based interdigitated electrodes for electrical stimulation of osteoblast cell lines

Min, Yong; Liu, Yidong; Poojari, Yadagiri; Wu, Jaclyn; Hildreth, Blake E.; Rosol, Thomas J.; Epstein, Arthur J.

doi:10.1016/j.synthmet.2014.10.035

Cited by 39 publications

(22 citation statements)

References 36 publications

(37 reference statements)

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“…131 PANI has been also been explored as a scaffold material for tissue regeneration and drug delivery applications. 59–63 Chemical stability and ability to withstand high temperature makes PANI an attractive material platform for a variety of applications. 64, 132 Additionally, PANI possesses a wide range of electrical conductivity at a very low operational voltage.…”

Section: Conductive Polymers For Nerve Growth Conduitsmentioning

confidence: 99%

“…64, 132 Additionally, PANI possesses a wide range of electrical conductivity at a very low operational voltage. 132 Like PPY, scaffolds derived from PANI have been also explored as a scaffold material in the possible application of bone, 59, 60 cardiac, 61–63 and skeletal muscle tissue engineering. 133 Thermoset PANI is insoluble in any organic solvents, thus making it impossible to fabricate structures by thermal and solution casting methods once it is polymerized.…”

Section: Conductive Polymers For Nerve Growth Conduitsmentioning

confidence: 99%

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Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits

Anderson

Shelke

Manoukian

et al. 2015

Crit Rev Biomed Eng

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Treatment of large peripheral nerve damages ranges from the use of an autologous nerve graft to a synthetic nerve growth conduit. Biological grafts, in spite of many merits, show several limitations in terms of availability and donor site morbidity, and outcomes are suboptimal due to fascicle mismatch, scarring, and fibrosis. Tissue engineered nerve graft substitutes utilize polymeric conduits in conjunction with cues both chemical and physical, cells alone and or in combination. The chemical and physical cues delivered through polymeric conduits play an important role and drive tissue regeneration. Electrical stimulation (ES) has been applied toward the repair and regeneration of various tissues such as muscle, tendon, nerve, and articular tissue both in laboratory and clinical settings. The underlying mechanisms that regulate cellular activities such as cell adhesion, proliferation, cell migration, protein production, and tissue regeneration following ES is not fully understood. Polymeric constructs that can carry the electrical stimulation along the length of the scaffold have been developed and characterized for possible nerve regeneration applications. We discuss the use of electrically conductive polymers and associated cell interaction, biocompatibility, tissue regeneration, and recent basic research for nerve regeneration. In conclusion, a multifunctional combinatorial device comprised of biomaterial, structural, functional, cellular, and molecular aspects may be the best way forward for effective peripheral nerve regeneration.

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Section: Conductive Polymers For Nerve Growth Conduitsmentioning

confidence: 99%

Section: Conductive Polymers For Nerve Growth Conduitsmentioning

confidence: 99%

Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits

Anderson

Shelke

Manoukian

et al. 2015

Crit Rev Biomed Eng

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“…However, the field needs to advance and be able to deliver highly individualized stimuli required by current and future personalized medicine 12 , 16 – 18 . Technology innovation has triggered the development of the cosurface capacitive electrode architecture for highly controlled and personalized electric stimulation systems 1 , 12 , 14 . This capacitive technology breaks the current barriers on stimulation capability as it is able to (i) deliver time- and region-dependent stimuli, (ii) generate a great amount of different stimuli, by varying waveform, magnitude, frequency, periodicity, stimulation exposure, etc., and (iii) deliver non-cytotoxic and non-genotoxic stimuli 12 .…”

Section: Introductionmentioning

confidence: 99%

Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems

Santos

Coutinho

Marote

et al. 2019

Sci Rep

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Cosurface electrode architectures are able to deliver personalized electric stimuli to target tissues. As such, this technology holds potential for a variety of innovative biomedical devices. However, to date, no detailed analyses have been conducted to evaluate the impact of stimulator architecture and geometry on stimuli features. This work characterizes, for the first time, the electric stimuli delivered to bone cellular tissues during in vitro experiments, when using three capacitive architectures: stripped, interdigitated and circular patterns. Computational models are presented that predict the influence of cell confluence, cosurface architecture, electrodes geometry, gap size between electrodes and power excitation on the stimuli delivered to cellular layers. The results demonstrate that these stimulators are able to deliver osteoconductive stimuli. Significant differences in stimuli distributions were observed for different stimulator designs and different external excitations. The thickness specification was found to be of utmost importance. In vitro experiments using an osteoblastic cell line highlight that cosurface stimulation at a low frequency can enhance osteoconductive responses, with some electrode-specific differences being found. A major feature of this type of work is that it enables future detailed analyses of stimuli distribution throughout more complex biological structures, such as tissues and organs, towards sophisticated biodevice personalization.

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“…Conjugated polymers have been used in two contexts as bone interfaces: as porous, cytocompatible tissue scaffolds suitable for hosting osteogenic cells; [ 254,255 ] and as interfaces for electrically promoting cell differentiation and growth. [ 157,230,253,348 ] Guex et al. used ice‐templated PEDOT:PSS scaffolds for culturing a preosteogenic precursor cell line (MCT3‐E1).…”

Section: In Vitro Applicationsmentioning

confidence: 99%

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Higgins

Fiego

Patrick

et al. 2020

Adv Materials Technologies

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Conjugated polymers exhibit interesting material and optoelectronic properties that make them well‐suited to the development of biointerfaces. Their biologically relevant mechanical characteristics, ability to be chemically modified, and mixed electronic and ionic charge transport are captured within the diverse field of organic bioelectronics. Conjugated polymers are used in a wide range of device architectures, and cell and tissue scaffolds. These devices enable biosensing of many biomolecules, such as metabolites, nucleic acids, and more. Devices can be used to both stimulate and sense the behavior of cells and tissues. Similarly, tissue interfaces permit interaction with complex organs, aiding both fundamental biological understanding and providing new opportunities for stimulating regenerative behaviors and bioelectronic based therapeutics. Applications of these materials are broad, and much continues to be uncovered about their fundamental properties. This report covers the current understanding of the fundamentals of conjugated polymer biointerfaces and their interactions with biomolecules, cells, and tissues in the human body. An overview of current materials and devices is presented, along with highlighted major in vivo and in vitro applications. Finally, open research questions and opportunities are discussed.

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Self-doped polyaniline-based interdigitated electrodes for electrical stimulation of osteoblast cell lines

Cited by 39 publications

References 36 publications

Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits

Peripheral Nerve Regeneration Strategies: Electrically Stimulating Polymer Based Nerve Growth Conduits

Capacitive technologies for highly controlled and personalized electrical stimulation by implantable biomedical systems

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

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