Self-directed orofacial grooming promotes social attraction in mice via chemosensory communication

Zhang, Yunfeng; Janke, Emma; Bhattarai, Janardhan P.; Wesson, Daniel W.; Ma, Minghong

doi:10.1016/j.isci.2022.104284

Cited by 10 publications

(5 citation statements)

References 36 publications

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“…3 h and 4h ). Since blue light activation of OT D3 neurons induces grooming 43 , 57 , it potentially influences behavioral measurements, including underestimation of the immobility time in the FST and TST. We rectified potential grooming-related deviations under light stimulation (detailed in Methods) and similar conclusions could be drawn (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice

Zhang,

Wu,

Wang

et al. 2023

Nat Commun

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The ventral striatum is a reward center implicated in the pathophysiology of depression. It contains islands of Calleja, clusters of dopamine D3 receptor-expressing granule cells, predominantly in the olfactory tubercle (OT). These OT D3 neurons regulate self-grooming, a repetitive behavior manifested in affective disorders. Here we show that chronic restraint stress (CRS) induces robust depression-like behaviors in mice and decreases excitability of OT D3 neurons. Ablation or inhibition of these neurons leads to depression-like behaviors, whereas their activation ameliorates CRS-induced depression-like behaviors. Moreover, activation of OT D3 neurons has a rewarding effect, which diminishes when grooming is blocked. Finally, we propose a model that explains how OT D3 neurons may influence dopamine release via synaptic connections with OT spiny projection neurons (SPNs) that project to midbrain dopamine neurons. Our study reveals a crucial role of OT D3 neurons in bidirectionally mediating depression-like behaviors, suggesting a potential therapeutic target.

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Section: Resultsmentioning

confidence: 99%

Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice

Zhang,

Wu,

Wang

et al. 2023

Nat Commun

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“…The open-field test is the most reliable indicator of emotionality in rodents. Self-grooming is an important behavior observed in rodents, primarily to maintain body hygiene, thermoregulation, chemocommunication, and stress reduction [ 67 ]. Chronic restraint stress, which has been well documented [ 68 ], is known to disrupt emotional activities, aligning with the findings of our study that emotional activities are significantly reduced in SIS rats compared to SG rats.…”

Section: Discussionmentioning

confidence: 99%

Role of Acorus calamus in preventing depression, anxiety, and oxidative stress in long-term socially isolated rats

Rai,

Joy,

Poojari

et al. 2023

Vet World

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Background and Aim: Social isolation stress (SIS) and individual housing have been shown to cause abnormal cognitive insufficiencies, altered anxiety levels, and signs of psychiatric diseases. Acorus calamus (AC), commonly known as Sweet Flag, has been widely used in India to treat neurological, metabolic, and respiratory disorders, indicating its potential therapeutic value. This study aimed to determine the antidepressant and antioxidative effects of AC on rats subjected to long-term, social-isolation-induced stress. Materials and Methods: This study involved 2-month-old male rats (24) weighing approximately 180200 g bred in-house. The rats were divided into four groups (n = 6): Group-1 received saline, Group-2 received SIS, Group-3 received only 50mg/kg AC, and Group-4 received 50mg/kg AC and SIS for 6 weeks. After this, behavioral, biochemical, and neuronal assay was conducted. Results: Behavioral experiments showed significantly higher activity levels (p < 0.001) in AC-treated rats than in the SIS group. In addition, rats subjected to SIS with AC treatment exhibited enhanced total antioxidants, superoxide dismutase, and neuronal assays compared to rats subjected to SIS alone. Conclusion: Acorus calamus treatment improved the antidepressant and antioxidant potential against SIS in rat brain tissue. Moreover, we proved that AC can effectively reverse the neurotoxicity induced by SIS in animal models. As we battle against the coronavirus disease 2019 pandemic and social isolation, AC could be considered a supplementary treatment to alleviate depressive-like symptoms in our present-day lifestyle. Keywords: antidepressant, antioxidative effects, brain tissue, coronavirus disease 2019 pandemic.

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“…Social interaction might be assessed in a couple of freely moving animals, placed in a simple or enriched context [ 12 , 29 , 30 , 31 ]. Alternatively, “guest” animals might be fixed with tether and collar assemblies [ 30 , 32 ], separated in a compartment of the test arena [ 33 , 34 , 35 ], or encaged [ 36 , 37 , 38 ]. The social stimuli might be isolated by partitions, which specifically limit or restrict visual, audial, haptic, or olfactory sensory inputs involved in animal interactions [ 39 , 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats

Rebik,

Broshevitskaya,

Kuzhuget

et al. 2023

Biomedicines

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Epilepsy or epileptic syndromes affect more than 70 million people, often comorbid with autism spectrum disorders (ASD). Seizures are concerned as a factor for social regression in ASD. A stepwise experimental approach to this problem requires an animal model to provoke seizures and monitor subsequent behavior. We used rats of the Krushinsky–Molodkina (KM) strain as a validated inbred genetic model for human temporal lobe epilepsy, with recently described social deficiency and hypolocomotion. Generalized tonic-clonic seizures in KM rats are sound-triggered, thus being controlled events in drug-naïve animals. We studied whether seizure experience would aggravate contact deficits in these animals. Locomotor and contact parameters were registered in “the elevated plus maze”, “socially enriched open field”, and “social novelty/social preference tests” before and after sound-provoked seizures. The triple seizure provocations minimally affected the contact behavior. The lack of social drive in KM rats was not accompanied by a submissive phenotype, as tested in “the tube dominance test”, but featured with a poor contact repertoire. Here, we confirmed our previous findings on social deficits in KM rats. The contact deficiency was dissociated from hypolocomotion and anxiety and did not correlate with seizure experience. It was established that experience of rare, generalized tonic-clonic convulsions did not lead to an impending regress in contact motivation, as seen in an animal model of genetic epilepsy and comorbid social deficiency. One of the oldest animal models for epilepsy has a translational potential to study mechanisms of social behavioral deficits in future neurophysiological and pharmacological research.

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Self-directed orofacial grooming promotes social attraction in mice via chemosensory communication

Cited by 10 publications

References 36 publications

Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice

Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice

Role of Acorus calamus in preventing depression, anxiety, and oxidative stress in long-term socially isolated rats

Audiogenic Seizures and Social Deficits: No Aggravation Found in Krushinsky–Molodkina Rats

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