Self-Diffusion of Fullerene С60 Derivatives in Aqueous Solutions and Suspensions of Erythrocytes According to Pulsed Field Gradient NMR Data

Avilova, Irina A.; Soldatova, Yu. V.; Kraevaya, Olga A.; Zhilenkov, Alexander V.; Dolgikh, E.; Kotelnikova, R. A.; Troshin, Pavel A.; Volkov, V. I.

doi:10.1134/s0036024421020047

Cited by 2 publications

(7 citation statements)

References 37 publications

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“…An analysis of the concentration dependence of the permeability of the erythrocyte membrane for formate molecules (Figure 5) showed a decrease in the p value from ≈3.6 × 10 −6 m/s to ≈3.8 × 10 −7 m/s with an increase in the concentration of the formate solution from 5 to 95 mM Thus, it was shown that the exchange of formate under the conditions of chemical and thermodynamic equilibrium proceeds rapidly, but the concentration dependence of its rate can be studied by using the PFG NMR method. Our team studied the permeability P of the erythrocyte membrane for water molecules and various C60 fullerene derivatives using the 1 H PFG NMR method [33,34]. The latter turned out to be possible for compounds whose signals in the 1 H NMR spectra do not overlap with the signals of the erythrocyte membrane components.…”

Section: Studies Of the Permeability Of The Erythrocyte Membranementioning

confidence: 99%

Water and Molecular Exchange in Biological Cells Studied Using 1H Pulsed Field Gradient NMR

Avilova

Volkov

2023

Membranes

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This review presents the results of studies of molecular exchange processes in various biological systems (erythrocytes, yeast, liposomes, etc.) performed using pulsed field gradient NMR (PFG NMR). The main theory of processing necessary for the analysis of experimental data is briefly presented: the extraction of self-diffusion coefficients, calculation of cell sizes, and permeability of cell membranes. Attention is paid to the results of assessing the permeability of biological membranes for water molecules and biologically active compounds. The results for other systems are also presented: yeast, chlorella, and plant cells. The results of studies of the lateral diffusion of lipid and cholesterol molecules in model bilayers are also presented.

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Section: Studies Of the Permeability Of The Erythrocyte Membranementioning

confidence: 99%

Water and Molecular Exchange in Biological Cells Studied Using 1H Pulsed Field Gradient NMR

Avilova

Volkov

2023

Membranes

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“…Below we have discussed the self-diffusion of water molecules, lateral diffusion and self-diffusion of pentasubstituted fullerene derivatives C 60 (with adducts of 3-mercaptopropanesulfonic acid C 60 [S(CH 2 ) 3 SO 3 Na] 5 H ( 1 ), mercaptopropionic acid C 60 [S(CH 2 ) 2 COOK] 5 H ( 2 ), proline C 60 [N(CH 2 ) 3 CHCOOK] 5 Cl ( 3 )) in a RBCs suspensions investigated by PFG NMR [ 171 , 172 , 173 ].…”

Section: Biological Systems: Protein and Cell Membranesmentioning

confidence: 99%

“…The study of self-diffusion of fullerene C 60 derivative molecules in a suspension of erythrocytes was carried out [ 172 , 173 ]. Water-soluble fullerene derivatives (WSFD) are promising materials for biomedical research and further pharmacological applications [ 180 , 181 , 182 ].…”

Section: Biological Systems: Protein and Cell Membranesmentioning

confidence: 99%

“… Diffusion decays at different diffusion times t d (indicated in the figure) of molecules 2 in RBCs suspension. Insert: diffusion decay of compound 2 in aqueous solution [ 173 ]. Reprinted with permission from [ 173 ].…”

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Molecular and Ionic Diffusion in Ion Exchange Membranes and Biological Systems (Cells and Proteins) Studied by NMR

et al. 2021

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The results of NMR, and especially pulsed field gradient NMR (PFG NMR) investigations, are summarized. Pulsed field gradient NMR technique makes it possible to investigate directly the partial self-diffusion processes in spatial scales from tenth micron to millimeters. Modern NMR spectrometer diffusive units enable to measure self-diffusion coefficients from 10−13 m2/sec to 10−8 m2/sec in different materials on 1 H, 2 H, 7 Li, 13 C, 19 F, 23 Na, 31 P, 133 Cs nuclei. PFG NMR became the method of choice for reveals of transport mechanism in polymeric electrolytes for lithium batteries and fuel cells. Second wide field of application this technique is the exchange processes and lateral diffusion in biological cells as well as molecular association of proteins. In this case a permeability, cell size, and associate lifetime could be estimated. The authors have presented the review of their research carried out in Karpov Institute of Physical Chemistry, Moscow, Russia; Institute of Problems of Chemical Physics RAS, Chernogolovka, Russia; Kazan Federal University, Kazan, Russia; Korea University, Seoul, South Korea; Yokohama National University, Yokohama, Japan. The results of water molecule and Li+, Na+, Cs+ cation self-diffusion in Nafion membranes and membranes based on sulfonated polystyrene, water (and water soluble) fullerene derivative permeability in RBC, casein molecule association have being discussed.

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Self-Diffusion of Fullerene С60 Derivatives in Aqueous Solutions and Suspensions of Erythrocytes According to Pulsed Field Gradient NMR Data

Cited by 2 publications

References 37 publications

Water and Molecular Exchange in Biological Cells Studied Using 1H Pulsed Field Gradient NMR

Water and Molecular Exchange in Biological Cells Studied Using 1H Pulsed Field Gradient NMR

Molecular and Ionic Diffusion in Ion Exchange Membranes and Biological Systems (Cells and Proteins) Studied by NMR

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