Positive psychology has begun to foster change in the study of adolescence by directing increased attention to the importance of building on adolescents' strengths and abilities as a means to promote positive outcomes. The purpose of this study was to explore the associations between hope, optimism, locus of control, self-determination, and life satisfaction in adolescents with and without cognitive disabilities using structural equation modeling. The results demonstrated comparability in the measurement of each of these constructs in adolescents with and without disabilities. Hope, optimism, locus of control, and self-determination were strongly correlated, and hope and optimism predicted life satisfaction in adolescents with and without cognitive disabilities. The implications of the findings for future research are discussed.