Self-defensive antimicrobial biomaterial surfaces

Xiao, Xiong; Zhao, Wenhan; Liang, Jenn‐Tai; Sauer, Karin; Libera, Matthew

doi:10.1016/j.colsurfb.2020.110989

Cited by 22 publications

(28 citation statements)

References 96 publications

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“…We have previously reported on the complexation of PAA microgels complexed with several different cationic antimicrobials and their resulting antimicrobial properties. , In contrast to studies using an individual microgel immobilized on the end of a pipette tip, we study a population of microgels that have been electrostatically deposited onto a transparent substrate. Importantly, while colistin-loaded PAA microgels demonstrate intriguing self-defensive antimicrobial behavior against E. coli in low-ionic-strength nutrient-free buffer, colistin/PAA complexation is unstable under the physiological conditions (pH 7.4; 0.14 M ionic strength) of particular interest for in vivo biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

“…23,24 In contrast to studies using an individual microgel immobilized on the end of a pipette tip, we study a population of microgels that have been electrostatically deposited onto a transparent substrate. Importantly, while colistin-loaded PAA microgels demonstrate intriguing self-defensive antimicrobial behavior 25 against E. coli in low-ionic-strength nutrient-free buffer, colistin/PAA complexation is unstable under the physiological conditions (pH 7.4; 0.14 M ionic strength) of particular interest for in vivo biomedical applications. The additional salt ions disrupt the electrostatic interactions between colistin amine groups and PAA acid groups, and the colistin is released in a rapid burst.…”

Section: ■ Introductionmentioning

confidence: 99%

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Salt Destabilization of Cationic Colistin Complexation within Polyanionic Microgels

Xiao

Zhao

et al. 2022

Macromolecules

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Polyelectrolyte complexation, with and without additional salts such as NaCl, has been of long-standing interest across such areas as polyelectrolyte blends, layer-by-layer (LbL) thin films, and coacervates. To better understand how to control complexation strength, we study polyanionic microgels involving sulfonic or carboxylic acids that interact with colistin, a small multivalent cationic (+5) macroion. Complexation causes microgel deswelling, which can be followed by in situ optical microscopy. The release of complexed colistin causes microgel swelling and is triggered by threshold levels of NaCl in the surrounding buffer. Differences in these thresholds together with differences in the Na+ doping of complexed microgels indicate that colistin complexation is stronger with poly(styrene sulfonate) (PSS) than it is with poly(acrylic acid) (PAA). Coarse-grained molecular dynamics simulations show that the free-energy decrease accompanying colistin-PSS complexation is significantly greater than that for colistin-PAA complexation. These simulations furthermore indicate that pendant aromatic groups in PSS play an important steric role as a spacer that creates polyanion conformations that maximize opportunities for both Coulombic and nonbonded Lennard-Jones interactions with colistin.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Salt Destabilization of Cationic Colistin Complexation within Polyanionic Microgels

Xiao

Zhao

et al. 2022

Macromolecules

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“…The current research in antimicrobial coating design and realization is focused on the creation of "smart" coatings as intelligent, reliable, long-life, and safe surface protection. Such smart coatings should ensure the delivery of antimicrobial agents only when bacteria are present [39]. These coatings are commonly based on targeted surface decoration with the utilization of so-called smart materials, able to rapidly and reversibly change their physicochemical properties in response to small changes in environmental conditions (for example, chemical conditions-pH, salt concentration, presence of biomolecules, or physical conditions-temperature, electrical potential, light, etc.)…”

Section: Smart Coatings-a General Conceptmentioning

confidence: 99%

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

et al. 2021

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Bacterial environmental colonization and subsequent biofilm formation on surfaces represents a significant and alarming problem in various fields, ranging from contamination of medical devices up to safe food packaging. Therefore, the development of surfaces resistant to bacterial colonization is a challenging and actively solved task. In this field, the current promising direction is the design and creation of nanostructured smart surfaces with on-demand activated amicrobial protection. Various surface activation methods have been described recently. In this review article, we focused on the “physical” activation of nanostructured surfaces. In the first part of the review, we briefly describe the basic principles and common approaches of external stimulus application and surface activation, including the temperature-, light-, electric- or magnetic-field-based surface triggering, as well as mechanically induced surface antimicrobial protection. In the latter part, the recent achievements in the field of smart antimicrobial surfaces with physical activation are discussed, with special attention on multiresponsive or multifunctional physically activated coatings. In particular, we mainly discussed the multistimuli surface triggering, which ensures a better degree of surface properties control, as well as simultaneous utilization of several strategies for surface protection, based on a principally different mechanism of antimicrobial action. We also mentioned several recent trends, including the development of the to-detect and to-kill hybrid approach, which ensures the surface activation in a right place at a right time.

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“…[31][32][33][34] To address the implant-infection problem, there has been a rapidly growing surge in the development of a wide variety of antimicrobial biomaterials over the past two decades. [35][36][37][38][39][40][41] This has necessitated the concurrent development and implementation of a range of in vitro methods designed to characterize the antimicrobial properties of these materials.…”

Section: Introductionmentioning

confidence: 99%

An in vitro model of microbial contamination in the operating room

et al. 2022

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Infection associated with tissue‐contacting biomedical devices is a compelling clinical problem initiated by the microbial colonization of the device surface. Among the possible sources of contaminating bacteria is the operating room (OR) itself, where viable bacteria in the atmosphere can sediment onto a device surface intraoperatively. We have developed an aerosolizing system that can reproducibly spray small quantities of aerosolized bacteria onto a surface to mimic OR contamination. This paper describes the design of the system and characterizes key aspects associated with its operation. The area density of sprayed bacteria is on the order of 102/cm2. Using titanium (Ti) alloy coupons as test substrates contaminated by staphylococci, we quantify the fraction of bacteria that are well adhered to the substrate, those that can be removed by sonication, and those that are not recovered after spraying. Despite the relatively low levels of surface contamination, we furthermore show that such a model is able to demonstrate a statistically significant reduction in colonization of Ti coupons modified by antimicrobial quaternary ammonium compounds relative to unmodified controls.

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Self-defensive antimicrobial biomaterial surfaces

Cited by 22 publications

References 96 publications

Salt Destabilization of Cationic Colistin Complexation within Polyanionic Microgels

Salt Destabilization of Cationic Colistin Complexation within Polyanionic Microgels

Physically Switchable Antimicrobial Surfaces and Coatings: General Concept and Recent Achievements

An in vitro model of microbial contamination in the operating room

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