Self-curing super-stretchable polymer/microgel complex coacervate gels without covalent bond formation

Wu, Shang-Lin; Zhu, Mingning; Lu, Dongdong; Milani, Amir H.; Lian, Qing; Fielding, Lee A.; Saunders, Brian R.; Derry, Matthew J.; Armes, Steven P.; Adlam, Daman J.; Hoyland, Judith A.

doi:10.1039/c9sc02555c

Cited by 20 publications

(23 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, supramolecular hydrogels stand out in that they achieve self-healing properties and entail tough properties [ 172 ]. Physical hydrogels that attain these properties can be prepared by PEs, where they typically display ionic mechanisms between oppositely charged ions [ 161 , 173 ]. However, to circumvent the strong associations of the strong interactions formed, polymerisation techniques are an attractive method to overcome this obstacle.…”

Section: Applicationsmentioning

confidence: 99%

“…However, to circumvent the strong associations of the strong interactions formed, polymerisation techniques are an attractive method to overcome this obstacle. To attain both toughness and self-healing properties, a polymerisation technique was utilised, where PEC coacervate gels were formed by mixing anionic polyacid microgels and cationic PEI [ 173 ]. Self-healing was attributed to the PEI chains that interpenetrate the anionic microgel, allowing for greater ionic crosslinks, where self-healing efficiency was reported at 92%.…”

Section: Applicationsmentioning

confidence: 99%

“… Image of self-healing PE gels, with gels cut (dashed line) and self-healed represented by the dye and original gel. Reproduced from [ 173 ]. …”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Polyelectrolyte Gels: Fundamentals, Fabrication and Applications

Wanasingha¹,

Dorishetty²,

Dutta³

et al. 2021

Gels

View full text Add to dashboard Cite

Polyelectrolyte gels are an important class of polymer gels and a versatile platform with charged polymer networks with ionisable groups. They have drawn significant recent attention as a class of smart material and have demonstrated potential for a variety of applications. This review begins with the fundamentals of polyelectrolyte gels, which encompass various classifications (i.e., origin, charge, shape) and crucial aspects (ionic conductivity and stimuli responsiveness). It further centralises recent developments of polyelectrolyte gels, emphasising their synthesis, structure–property relationships and responsive properties. Sequentially, this review demonstrates how polyelectrolyte gels’ flourishing properties create attractiveness to a range of applications including tissue engineering, drug delivery, actuators and bioelectronics. Finally, the review outlines the indisputable appeal, further improvements and emerging trends in polyelectrolyte gels.

show abstract

Section: Applicationsmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Polyelectrolyte Gels: Fundamentals, Fabrication and Applications

Wanasingha¹,

Dorishetty²,

Dutta³

et al. 2021

Gels

View full text Add to dashboard Cite

show abstract

“…Alternatively, physically assembled microgels can be crosslinked through exposure to UV light [20] and microgels can also be assembled by harnessing dynamic ionic interactions. [21] Unfortunately, most approaches to creating porous structures within hydrogel scaffolds require advanced fabrication techniques and technologies that are relatively expensive and time consuming to perform. Consequently, it is usually only feasible to produce scaffolds in small quantities.…”

Section: Doi: 101002/marc202000191mentioning

confidence: 99%

“…Alternatively, physically assembled microgels can be crosslinked through exposure to UV light [ 20 ] and microgels can also be assembled by harnessing dynamic ionic interactions. [ 21 ]…”

Section: Figurementioning

confidence: 99%

Granular Cellulose Nanofibril Hydrogel Scaffolds for 3D Cell Cultivation

Gehlen

Jürgens

Omidinia-Anarkoli

et al. 2020

Macromol. Rapid Commun.

View full text Add to dashboard Cite

The replacement of diseased and damaged organs remains an challenge in modern medicine. However, through the use of tissue engineering techniques, it may soon be possible to (re)generate tissues and organs using artificial scaffolds. For example, hydrogel networks made from hydrophilic precursor solutions can replicate many properties found in the natural extracellular matrix (ECM) but often lack the dynamic nature of the ECM, as many covalently crosslinked hydrogels possess elastic and static networks with nanoscale pores hindering cell migration without being degradable. To overcome this, macroporous colloidal hydrogels can be prepared to facilitate cell infiltration. Here, an easy method is presented to fabricate granular cellulose nanofibril hydrogel (CNF) scaffolds as porous networks for 3D cell cultivation. CNF is an abundant natural and highly biocompatible material that supports cell adhesion. Granular CNF scaffolds are generated by pre‐crosslinking CNF using calcium and subsequently pressing the gel through micrometer‐sized nylon meshes. The granular solution is mixed with fibroblasts and crosslinked with cell culture medium. The obtained granular CNF scaffold is significantly softer and enables well‐distributed fibroblast growth. This cost‐effective material combined with this efficient and facile fabrication technique allows for 3D cell cultivation in an upscalable manner.

show abstract

Programmed Multiresponsive Hydrogel Assemblies with Light‐Tunable Mechanical Properties, Actuation, and Fluorescence

Lu¹,

Zhu²,

Wu³

et al. 2020

Adv Funct Materials

Self Cite

View full text Add to dashboard Cite

Fabrication strategies for programmed hydrogels that provide precise spatial control with predetermined responses to external stimuli are highly desirable. In this study, a partially reversible light‐driven assembly (PRLDA) method is introduced to construct multiresponsive hydrogels utilizing microgel (MG) particle building blocks (swollen diameter of 107 nm). No other material is required to prepare the gels beyond the MGs themselves. Facile preparation of multiresponsive hydrogels that are reversibly responsive to light, pH, and temperature using phototriggered covalent interlinking of coumarin‐based MGs is demonstrated. The gels have phototuneable moduli and swelling ratios and show light‐assisted healing and reshaping. Remarkably, the intrinsic fluorescence of the gels undergoes a reversible light‐triggered wavelength‐shift. The emission peak blueshifted from 420 to 390 nm upon irradiation with 365 nm light. The PRLDA gels can be constructed using either positive or negative photopatterning. It is shown that the gels can be exploited for multiresponsive cytocompatible actuators, grippers, and ON/OFF circuit components as well as anticounterfeit gels. The PRLDA method provides new insight into programmed gel property control and has excellent potential for biomaterial and optoelectronic applications.

show abstract

Self-curing super-stretchable polymer/microgel complex coacervate gels without covalent bond formation

Abstract: A new class of super-stretchable gel that does not involve covalent bonds being formed is introduced by mixing pre-formed pH-responsive microgel particles and branched polyethyleneimine followed by annealing at T ≥ 37 °C.

Cited by 20 publications

References 58 publications

Polyelectrolyte Gels: Fundamentals, Fabrication and Applications

Polyelectrolyte Gels: Fundamentals, Fabrication and Applications

Granular Cellulose Nanofibril Hydrogel Scaffolds for 3D Cell Cultivation

Programmed Multiresponsive Hydrogel Assemblies with Light‐Tunable Mechanical Properties, Actuation, and Fluorescence

Contact Info

Product

Resources

About