Self-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications

Şahiner, Nurettin

doi:10.3390/molecules26092429

Cited by 11 publications

(4 citation statements)

References 52 publications

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“…This may be due to the three-dimensional structure of the cryogels in comparison to the linear CS polymer, as well as to the existence of DVS groups that may have some kind of affinity to bind with Fe(II) ions. The similar behavior was also observed for tannic acid and poly(tannic acid) particles; the particle form of tannic acid afforded significant increase in Fe(II) cheating capability [ 35 ]. Moreover, it was also reported that a flavonoid, rutin molecule showed no binding ability for the Fe(II) ion, whereas the micro/nanogels form of rutin had considerable Fe(II) binding ability [ 5 ].…”

Section: Resultssupporting

confidence: 58%

Chondroitin Sulfate-Based Cryogels for Biomedical Applications

Demirci

Şahiner

Ari

et al. 2021

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Cryogels attained from natural materials offer exceptional properties in applications such as tissue engineering. Moreover, Halloysite Nanotubes (HNT) at 1:0.5 weight ratio were embedded into CS cryogels to render additional biomedical properties. The hemolysis index of CS cryogel and CS:HNT cryogels was calculated as 0.77 ± 0.41 and 0.81 ± 0.24 and defined as non-hemolytic materials. However, the blood coagulation indices of CS cryogel and CS:HNT cryogels were determined as 76 ± 2% and 68 ± 3%, suggesting a mild blood clotting capability. The maximum% swelling capacity of CS cryogel was measured as 3587 ± 186%, 4014 ± 184%, and 3984 ± 113%, at pH 1.0, pH 7.4 and pH 9.0, respectively, which were reduced to 1961 ± 288%, 2816 ± 192, 2405 ± 73%, respectively, for CS:HNT cryogel. It was found that CS cryogels can hydrolytically be degraded 41 ± 1% (by wt) in 16-day incubation, whereas the CS:HNT cryogels degraded by 30 ± 1 wt %. There is no chelation for HNT and 67.5 ± 1% Cu(II) chelation for linear CS was measured. On the other hand, the CS cryogel and CS:HNT cryogel revealed Cu(II) chelating capabilities of 60.1 ± 12.5%, and 43.2 ± 17.5%, respectively, from 0.1 mg/mL Cu(II) ion stock solution. Additionally, at 0.5 mg/mL CS, CS:HNT, and HNT, the Fe(II) chelation capacity of 99.7 ± 0.6, 86.2 ± 4.7% and only 11.9 ± 4.5% were measured, respectively, while no Fe(II) was chelated by linear CS chelated Fe(II). As the adjustable and controllable swelling properties of cryogels are important parameters in biomedical applications, the swelling properties of CS cryogels, at different solution pHs, e.g., at the solution pHs of 1.0, 7.4 and 9.0, were measured as 3587 ± 186%, 4014 ± 184%, and 3984 ± 113%, respectively, and the maximum selling% values of CS:HNT cryogels were determined as 1961 ± 288%, 2816 ± 192, 2405 ± 73%, respectively, at the same conditions. Alpha glucosidase enzyme interactions were investigated and found that CS-based cryogels can stimulate this enzyme at any CS formulation.

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Section: Resultssupporting

confidence: 58%

Chondroitin Sulfate-Based Cryogels for Biomedical Applications

Demirci

Şahiner

Ari

et al. 2021

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“…In this context, it is known that some polyphenols have an affinity for binding Fe 2+ ions. Tannic acid (TA) chelates with Fe 2+ ions [ 97 ]. Depending on the concentration, other phenolic compounds such as catechin molecules also chelate with Fe 2+ ions in the aqueous environments [ 98 ].…”

Section: Novel Phyto-therapeutic Approaches In Admentioning

confidence: 99%

A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease

Şahiner

Yilmaz

Gungor

et al. 2023

JFB

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Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of function and death of nerve cells. A great deal of effort is being made to understand the pathogenesis of neurodegenerative diseases. In particular, the prevalence of Alzheimer’s disease (AD) is quite high, and only symptomatic therapy is available due to the absence of radical treatment. The aim of this review is to try to elucidate the general pathogenesis of AD, to provide information about the limit points of symptomatic treatment approaches, and to emphasize the potential neurologic effects of phytocompounds as new tools as therapeutic agents for disease prevention, retardation, and therapy. This survey also covers the notable properties of herbal compounds such as their effects on the inhibition of an enzyme called acetylcholinesterase, which has significant value in the treatment of AD. It has been proven that phytopharmaceuticals have long-term effects that could protect nervous system health, eliminate inflammatory responses, improve cognitive damage, provide anti-aging effects in the natural aging process, and alleviate dementia sequelae. Herbal-based therapeutic agents can afford many advantages and can be used as potentially as new-generation therapeutics or complementary agents with high compliance, fewer adverse effects, and lower cost in comparison to the traditional pharmaceutical agents in the fight against AD.

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“…Polyethylene terephthalate (PET) is the most widespread single use plastic but, its natural properties are only marginally resistant to ultraviolet light penetration which can lead to the initiation of the autoxidation process . Many natural compounds (e.g., tannic acid, catechin, cyanidin, caffeic acid, quercetin, ellagic acid, xanthan and 8-hydroxygenistein) have been demonstrated as effective autoxidation reducing molecules − with an order of effectiveness of some of them as catechin > cyanidin ≈ caffeic acid > quercetin > ellagic acid …”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl chloride) Derived Food Packaging Applications with Antioxidative and Anticancer Properties

Hazer

Karahaliloğlu

Ashby

2023

ACS Food Sci. Technol.

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Novel poly(vinyl chloride) (PVC) polymer derivatives based on the natural antioxidants vanillic acid, cinnamic acid, coumaric acid, caffeic acid, and naringin were prepared and characterized for their chemical structures, molecular weights, thermal and mechanical properties, and antioxidant characteristics toward linseed oil. Oxidation delay times (induction periods) were prolonged from 1 to 6 days beyond the pristine PVC, with the naringin-based derivative being the most effective. Biological activities of the PVC derivatives were determined and showed the substituted PVC polymers effectively inhibited the formation of reactive oxygen species (ROS) in the MCF-7 cell line according to the following sequence: cinnamic acid ≥ caffeic acid ≥ vanillic acid = naringin ≥ coumaric acid, with only a minimal effect on healthy L929 cells. These results indicate that the derivatives produced in this study have potential applications as active packaging materials for food and as antibacterial/anticancer biomaterials in areas such as tissue engineering.

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Self-Crosslinked Ellipsoidal Poly(Tannic Acid) Particles for Bio-Medical Applications

Cited by 11 publications

References 52 publications

Chondroitin Sulfate-Based Cryogels for Biomedical Applications

Chondroitin Sulfate-Based Cryogels for Biomedical Applications

A Review on Phyto-Therapeutic Approaches in Alzheimer’s Disease

Poly(vinyl chloride) Derived Food Packaging Applications with Antioxidative and Anticancer Properties

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