Self-cross-linked Hyaluronic Acid Hydrogel in Ethmoidectomy: A Randomized, Controlled Trial

Matheny, Keith E.; Tseng, Ewen; Carter, Kenny B.; Cobb, William B.; Fong, Karen

doi:10.2500/ajra.2014.28.4106

Cited by 14 publications

(6 citation statements)

References 42 publications

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“…Self-cross-linked HA demonstrated the ability to facilitate mucocillary regeneration. 21 In this study, 90.2% of the patients (74/82) in the HA hydrogel group had epithelial mucosa lining the ostia, which was higher than that in the control group (70.9%, 56/79) at the 2-week follow-up. The success rate of ostial patency reached 91.5% (75/82) in the HA hydrogel group, as opposed to the control group 77.2% (61/79).…”

Section: Discussionmentioning

confidence: 50%

“…It was reported that the synechiae was significantly less in the self-cross-linked HA group than in the Stammberger group. Self-cross-linked HA demonstrated the ability to facilitate mucocillary regeneration 21 …”

Section: Discussionmentioning

confidence: 99%

“…HA have been developed and used successfully to promote wound healing and hemostasis in the nasal cavities, as well as other parts of the body 17–20 . However, because of its poor stability, easy absorbent and it cannot remain on the surface of the ostia, limited its application in En-DCR.A unique, self-cross-linked HA hydrogel has been designed to improve the stability and optimized to give a suitable retention and absorption time, has shown favorable outcomes in both remucosalization as well as the minimization of bleeding in the sinus cavities in a previous study 21 …”

mentioning

confidence: 99%

“…[17][18][19][20] However, because of its poor stability, easy absorbent and it cannot remain on the surface of the ostia, limited its application in En-DCR.A unique, self-cross-linked HA hydrogel has been designed to improve the stability and optimized to give a suitable retention and absorption time, has shown favorable outcomes in both remucosalization as well as the minimization of bleeding in the sinus cavities in a previous study. 21 Our study aimed to investigate whether self-cross-linked HA hydrogel fill stimulates wound mucosal regeneration and its epithelialization around the ostia to improve long-term ostial patency in En-DCR.…”

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confidence: 99%

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Self-Cross-Linked Hyaluronic Acid Hydrogel in Endonasal Endoscopic Dacryocystorhinostomy: A Randomized, Controlled Trial

Tu²,

Zhou³

et al. 2021

Journal of Craniofacial Surgery

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Purpose: To investigate whether self-cross-linked HA hydrogel fill stimulates wound mucosal regeneration and its epithelialization around the ostia to improve long-term ostial patency in endonasal endoscopic dacryocystorhinostomy (En-DCR). Methods: One hundred and ninety-two patients with unilateral primary chronic dacryocystitis (PCD) were randomized divided into 2 groups: group A (the HA hydrogel group) and group B (the control group). All patients underwent En-DCR. The HA hydrogel group received HA hydrogel filling the ostium at the end of the surgery and the control group received no treatment. The mucosal epithelialization of the wound, the formation of granulation, the formation of scars, and the success rate of ostial patency were compared. Results: Our study included 82 patients in group A and 79 patients in group B. At the 2-week follow up, 74 patients (90.2%) in the group A had a healed ostium with a lining of intact epithelial mucosa. It was higher when compared with 56 patients (70.9%) in group B (X 2 ¼ 9.698, P < 0.05). At the 12-month follow up, Granulation were present in 7.3% of patients in group A which was significantly lower than the 19.0% of patients in group B (X2 ¼ 4.831, P < 0.05). No statistical difference was found with scars formation between 2 groups (X 2 ¼ 1.607, P ¼ 0.205). The success rate of ostial patency was 89.0% (73/82) in group A and 77.2% (61/79) in group B. The success rate was much higher in group A than group B (X2 ¼ 4.02, P < 0.05). Conclusion: Self-cross-linked HA hydrogel may enhance the success rate of En-DCR for PCD by promoting mucosal epithelial healing and preventing excessive granulation.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Self-Cross-Linked Hyaluronic Acid Hydrogel in Endonasal Endoscopic Dacryocystorhinostomy: A Randomized, Controlled Trial

Tu²,

Zhou³

et al. 2021

Journal of Craniofacial Surgery

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show abstract

“…The authors concluded this practice can be appropriate in selected cases. Lastly, Matheny et al 9 report their findings from a randomized clinical trial evaluating use of hyaluronic acid gel versus carboxymethylcellulose after sinus surgery. The hyaluronic acid was associated with more optimal healing at the end of the 12 week potoperative period.…”

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confidence: 99%

Editorial: Studying the spectrum of allergic and rhinologic disease

Soler¹

2014

Am J Rhinol�Allergy

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The American Journal of Allergy and Rhinology is committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. The current issue furthers this mission, presenting novel studies investigating the molecular mechanisms of allergic rhinitis and chronic rhinosinusitis. Also presented are findings from several systematic reviews and randomized clinical trials which will directly impact care for patients with both allergic and rhinologic disease. High quality research is being done worldwide and this current reality is reflected in the breadth of regions represented by these investigators, including the Americas, Asia, Europe, and Australia. The prevalence of allergic rhinitis continues to increase worldwide, resulting in significant patient morbidity and healthcare expenditure. Min et al 1

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Steroid-eluting sinus stents for improving symptoms in chronic rhinosinusitis patients undergoing functional endoscopic sinus surgery

Huang

Hwang

Sun

2015

Cochrane Database of Systematic Reviews

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Self-cross-linked Hyaluronic Acid Hydrogel in Ethmoidectomy: A Randomized, Controlled Trial

Abstract: Self-cross-linked HA hydrogel provides superior wound healing to CMC after ethmoidectomy.

Cited by 14 publications

References 42 publications

Self-Cross-Linked Hyaluronic Acid Hydrogel in Endonasal Endoscopic Dacryocystorhinostomy: A Randomized, Controlled Trial

Self-Cross-Linked Hyaluronic Acid Hydrogel in Endonasal Endoscopic Dacryocystorhinostomy: A Randomized, Controlled Trial

Editorial: Studying the spectrum of allergic and rhinologic disease

Steroid-eluting sinus stents for improving symptoms in chronic rhinosinusitis patients undergoing functional endoscopic sinus surgery

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