The effective adhesive properties of heterogeneous thin films are characterized through a combined experimental and theoretical investigation. By bridging scales, we show how variations of elastic or adhesive properties at the microscale can significantly affect the effective peeling behavior of the adhesive at the macroscale. Our study reveals three elementary mechanisms in heterogeneous systems involving front propagation: (i) patterning the elastic bending stiffness of the film produces fluctuations of the driving force resulting in dramatically enhanced resistance to peeling; (ii) optimized arrangements of pinning sites with large adhesion energy are shown to control the effective system resistance, allowing the design of highly anisotropic and asymmetric adhesives; (iii) heterogeneities of both types result in front motion instabilities producing sudden energy releases that increase the overall adhesion energy. These findings open potentially new avenues for the design of thin films with improved adhesion properties, and motivate new investigation of other phenomena involving front propagation.PACS numbers: 62.20. Mk, 46.50.+a, 68.35.Ct Bridging microscale properties of materials with their effective mechanical behavior at the macroscale is a major challenge in both pure and applied science. A great deal of research effort has been dedicated to the study of effective elastic properties in heterogeneous systems. Composite materials, structures and meta-materials can achieve extraordinary effective properties, e. g. negative Poisson's ratio [1] or stiffness greater than diamond [2], and elegant homogenization techniques have been developed in order to efficiently link micro to macroscale in elastic settings [3][4][5]. Surprisingly, our understanding of the role of heterogeneities on the overall resistance of these systems to failure resulting from the propagation of free boundaries and free discontinuities is rather limited, despite the major importance of this question in engineering science. For example, stress concentration generated by brittle cracks makes the macroscopic system extremely sensitive to microscopic features -the scale invariant roughening of cracks as well as their highly intermittent dynamics are good illustrations of this effect [6,7] -raising fundamental impediments to the development of reliable homogenization techniques for fracture problems.In this letter, we address the challenge of finding the macroscopic resistance to front propagation in a heterogeneous media in the context of thin film peeling. There has been a recent renewal of interest in adhesive systems driven by the exploration of exceptional properties of biological systems like geckos. Consequently, much attention has focused on adhesion enhancement achieved by 3D features of the adhesive surface, such as arrays of fibrils [8,9] or hierarchical structures [10]. Here, we will show that such a rather complex microstructure is not required to achieve enhanced adhesion: heterogeneities in the elastic properties of the film ...