Background: Hemoglobinopathy is a group of genetic disorders transmitted from parents to their children spread all over the world and is characterized by a decrease or absence of the normal synthesis of hemoglobin, as in thalassemia, or the abnormal structure of hemoglobin as in sickle cell anemia, has an impact on physical and Psychosocial wellness, which leads to increased fears about physical appearance, and interference in the process of gaining independence and healthy relationships with family, friends, and society. Aims: To assess physical wellness among adolescents with hemoglobinopathic disorders. As well as to Identify association between the physical wellness with certain demographic data. Methods: A cross-sectional descriptive study design was used during the period from February 2, 2022 to May 2, 2022. This study was conducted in Babylon Governorate on (150) patients with hemoglobinopathic disorders at Babylon Teaching Hospital for Women and Children; 50% of patients aged 10-19 years were selected. Data were collected using a modified questionnaire and analyzed electronically by using SPSS 26. Results: Less than two-fifths of patients range in age from (10–13) years with mean age (of 14.7), half of them are males and the other half are females.