Self-association of the glycopeptide antibiotic teicoplanin A2 in aqueous solution studied by molecular hydrodynamics

Chun, Taewoo; Pattem, Jacob; Gillis, Richard B.; Dinu, Vlad; Yakubov, Gleb E.; Corfield, Anthony P.; Harding, Stephen E.

doi:10.1038/s41598-023-28740-8

Cited by 4 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Teicoplanin is used to treat multidrug-resistant Gram-positive bacteria, such as MRSA and Enterococci, that are responsible for life-threatening infectious illnesses [ 102 ]. This glycopeptide antibiotic was initially isolated from Actinoplanes teichomyceticus , which was identified in 1978 from an Indian soil sample [ 103 ].…”

Section: Glycopeptidesmentioning

confidence: 99%

“…Both antibiotics work by forming hydrogen bonds with the D-Ala-D-Ala C-terminus of the pentapeptide substrate to prevent the formation of the peptidoglycan chains that make up bacterial cell walls [ 104 ]. The hydrophobic lipid chain of this pentapeptide substrate is also known to interact with teicoplanin, placing the antibiotic next to the peptidoglycan [ 102 , 105 ].…”

Section: Glycopeptidesmentioning

confidence: 99%

See 1 more Smart Citation

Synthetic and Semisynthetic Compounds as Antibacterials Targeting Virulence Traits in Resistant Strains: A Narrative Updated Review

et al. 2023

View full text Add to dashboard Cite

This narrative review paper provides an up-to-date overview of the potential of novel synthetic and semisynthetic compounds as antibacterials that target virulence traits in resistant strains. The review focused on research conducted in the last five years and investigated a range of compounds including azoles, indoles, thiophenes, glycopeptides, pleuromutilin derivatives, lactone derivatives, and chalcones. The emergence and spread of antibiotic-resistant bacterial strains is a growing public health concern, and new approaches are urgently needed to combat this threat. One promising approach is to target virulence factors, which are essential for bacterial survival and pathogenesis, but not for bacterial growth. By targeting virulence factors, it may be possible to reduce the severity of bacterial infections without promoting the development of resistance. We discuss the mechanisms of action of the various compounds investigated and their potential as antibacterials. The review highlights the potential of targeting virulence factors as a promising strategy to combat antibiotic resistance and suggests that further research is needed to identify new compounds and optimize their efficacy. The findings of this review suggest that novel synthetic and semisynthetic compounds that target virulence factors have great potential as antibacterials in the fight against antibiotic resistance.

show abstract

Section: Glycopeptidesmentioning

confidence: 99%

Section: Glycopeptidesmentioning

confidence: 99%

Synthetic and Semisynthetic Compounds as Antibacterials Targeting Virulence Traits in Resistant Strains: A Narrative Updated Review

et al. 2023

View full text Add to dashboard Cite

show abstract

Cyclic peptides: A powerful instrument for advancing biomedical nanotechnologies and drug development

Martian,

Tertis,

Leonte

et al. 2025

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Comparative hydrodynamic and nanoscale imaging study on the interactions of teicoplanin-A2 and bovine submaxillary mucin as a model ocular mucin

Chun

Pattem

Gillis

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Glycopeptide antibiotics are regularly used in ophthalmology to treat infections of Gram-positive bacteria. Aggregative interactions of antibiotics with mucins however can lead to long exposure and increases the risk of resistant species. This study focuses on the evaluation of potential interactions of the last line of defence glycopeptide antibiotic teicoplanin with an ocular mucin model using precision matrix free hydrodynamic and microscopic techniques: sedimentation velocity in the analytical ultracentrifuge (SV-AUC), dynamic light scattering (DLS) and atomic force microscopy (AFM). For the mixtures of teicoplanin at higher doses (1.25 mg/mL and 12.5 mg/mL), it was shown to interact and aggregate with bovine submaxillary mucin (BSM) in the distributions of both sedimentation coefficients by SV-AUC and hydrodynamic radii by DLS. The presence of aggregates was confirmed by AFM for higher concentrations. We suggest that teicoplanin eye drop formulations should be delivered at concentrations of < 1.25 mg/mL to avoid potentially harmful aggregations.

show abstract

Self-association of the glycopeptide antibiotic teicoplanin A2 in aqueous solution studied by molecular hydrodynamics

Cited by 4 publications

References 58 publications

Synthetic and Semisynthetic Compounds as Antibacterials Targeting Virulence Traits in Resistant Strains: A Narrative Updated Review

Synthetic and Semisynthetic Compounds as Antibacterials Targeting Virulence Traits in Resistant Strains: A Narrative Updated Review

Cyclic peptides: A powerful instrument for advancing biomedical nanotechnologies and drug development

Comparative hydrodynamic and nanoscale imaging study on the interactions of teicoplanin-A2 and bovine submaxillary mucin as a model ocular mucin

Contact Info

Product

Resources

About