Self-assisted wound healing using piezoelectric and triboelectric nanogenerators

Abstract

The complex process of wound healing depends on the coordinated interaction between various immunological and biological systems, which can be aided by technology. This present review provides a broad overview of the medical applications of piezoelectric and triboelectric nanogenerators, focusing on their role in the development of wound healing technology. Based on the finding that the damaged epithelial layer of the wound generates an endogenous bioelectric field to regulate the wound healing process, development of technological device for providing an exogenous electric field has therefore been paid attention. Authors of this review focus on the design and application of piezoelectric and triboelectric materials to manufacture self-powered nanogenerators, and conclude with an outlook on the current challenges and future potential in meeting medical needs and commercialization.

Smart biomaterials and their potential applications in tissue engineering

“…Piezoelectric materials are useful for tissue engineering as electroactive scaffolds for tissue repair and regeneration, which may deliver varying electrical stimulation under mechanical stress without requiring an external power supply. 340 The application of nanomaterials and nanostructures to gather mechanical energy has led to the creation of piezoelectric nanogenerators (PENG) in the field of biomedicine. A piezoelectric generator (PENG) is an energyharvesting device that can transform ambient energy (e.g., mechanical, solar and thermal power) into electric energy using nanostructured piezoelectric materials.…”

Recent Progress of Nanogenerators for Green Energy Harvesting: Performance, Applications, and Challenges

“…In comparison to individual nanogenerators, this nanogenerator type can provide high and efficient power density [ 95 ]. Recent research has led to the development of hybrid nanogenerators based on piezoelectric–pyroelectric [ 96 , 97 , 98 ], triboelectric–piezoelectric [ 31 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 ], electromagnetic–triboelectric [ 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 ], triboelectric–piezoelectric–pyroelectric [ 133 , 134 , 135 , 136 ], triboelectric–piezoelectric–electromagnetic [ 137 , 138 , 139 , ...…”

Physical Stimulation Combined with Biomaterials Promotes Peripheral Nerve Injury Repair

“…Self-powered means that the device can generate electric energy without using an external power supply during operation [ 34 ]. As the advantages of bio-conductive scaffolds, such as cost-effectiveness and reproducibility, have gradually emerged, some scholars have proposed integrating self-powered functions and scaffolds to design a self-powered nerve scaffold [ 35 ], which can better combine the advantages of both [ 36 ].…”